Publications

2015

Karner CM, Long F, Solnica-Krezel L, Monk KR, Gray RS. Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice. Hum Mol Genet. 2015 May 7. pii: ddv170. [Epub ahead of print] PubMed PMID: 25954032.

Langenhan T, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, Monk KR. Model organisms in GPCR research. Mol Pharmacol. 2015 May 15. [Epub ahead of print] PubMed PMID: 25979002.

Monk KR, Hamann J, Langenhan T, Nijmeijer S, Schoneberg T, Liebscher I. Adhesion GPCRs: From in vitro pharmacology to in vivo mechanisms. Mol Pharmacol. 2015 May 8. [Epub ahead of print] PubMed PMID: 25956432.

Desai NA, Udani V. GPR56-related polymicrogyria: Clinicoradiologic profile of 4 patients. J Child Neurol. 2015 Apr 28. pii: 0883073815583335. [Epub ahead of print] PubMed PMID: 25922261.

Hsiao CC, Keysselt K, Chen HY, Sittig D, Hamann J, Lin HH, Aust G. The Adhesion GPCR CD97/ADGRE5 inhibits apoptosis. Int J Biochem Cell Biol. 2015 Jun 9;65:197-208. PubMed PMID: 26071181.

Vanhollebeke B, Stone OA, Bostaille N, Cho C, Zhou Y, Maquet E, Gauquier A, Cabochette P, Fukuhara S, Mochizuki N, Nathans J, Stainier DY. Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. Elife. 2015 Jun 8;4. PubMed PMID: 26051822.

Ravenscroft G, Nolent F, Rajagopalan S, Meireles AM, Paavola KJ, Gaillard D, Alanio E, Buckland M, Arbuckle S, Krivanek M, Maluenda J, Pannell S, Gooding R, Ong RW, Allcock RJ, Carvalho ED, Carvalho MD, Kok F, Talbot WS, Melki J, Laing NG. Mutations of GPR126 are responsible for severe arthrogryposis multiplex congenita. Am J Hum Genet. 2015 Jun 4;96(6):955-61. PubMed PMID: 26004201.

Scholz N, Gehring J, Guan C, Ljaschenko D, Fischer R, Lakshmanan V, Kittel RJ, Langenhan T. The adhesion GPCR Latrophilin/CIRL shapes mechanosensation. Cell Rep. 2015 May 12;11(6):866-74. PubMed PMID: 25937282.

Stoveken HM, Hajduczok AG, Xu L, Tall GG. Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist. Proc Natl Acad Sci U S A. 2015 May 12;112(19):6194-9. PubMed PMID: 25918380.

Ariestanti DM, Ando H, Hirose S, Nakamura N. Targeted disruption of Ig-Hepta/Gpr116 causes emphysema-like symptoms that are associated with alveolar macrophage activation. J Biol Chem. 2015 Apr 24;290(17):11032-40. PubMed PMID: 25778400.

Jackson VA, Del Toro D, Carrasquero M, Roversi P, Harlos K, Klein R, Seiradake E. Structural basis of latrophilin-FLRT interaction. Structure. 2015 Apr 7;23(4):774-81. PubMed PMID: 25728924.

Ressl S, Vu BK, Vivona S, Martinelli DC, Südhof TC, Brunger AT. Structures of C1q-like proteins reveal unique features among the C1q/TNF superfamily. Structure. 2015 Apr 7;23(4):688-99. PubMed PMID: 25752542.

Zhu D, Li C, Swanson AM, Villalba RM, Guo J, Zhang Z, Matheny S, Murakami T, Stephenson JR, Daniel S, Fukata M, Hall RA, Olson JJ, Neigh GN, Smith Y, Rainnie DG, Van Meir EG. BAI1 regulates spatial learning and synaptic plasticity in the hippocampus. J Clin Invest. 2015 Apr 1;125(4):1497-508. PubMed PMID: 25751059.

Ohta S, Sakaguchi S, Kobayashi Y, Mizuno N, Tago K, Itoh H. Agonistic antibodies reveal the function of GPR56 in human glioma U87-MG cells. Biol Pharm Bull. 2015;38(4):594-600. PubMed PMID: 25832639.

Santos-Silva R, Passas A, Rocha C, Figueiredo R, Mendes-Ribeiro J, Fernandes S, Biskup S, Leão M. Bilateral frontoparietal polymicrogyria: a novel GPR56 mutation and an unusual phenotype. Neuropediatrics. 2015 Apr;46(2):134-8. PubMed PMID: 25642806.

Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev. 2015 Apr;67(2):338-67. PubMed PMID: 25713288.

Santos-Silva R, Passas A, Rocha C, Figueiredo R, Mendes-Ribeiro J, Fernandes S, Biskup S, Leão M. Bilateral frontoparietal polymicrogyria: a novel GPR56 mutation and an unusual phenotype. Neuropediatrics. 2015 Apr;46(2):134-8. PubMed PMID: 25642806.

Rao TN, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN, Serwold T, Pimanda JE, Wagers AJ. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Stem Cell Res. 2015 Feb 18;14(3):307-322. PubMed PMID: 25840412.

Harty BL, Krishnan A, Sanchez NE, Schiöth HB, Monk KR. Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. BMC Genomics. 2015 Feb 8;16:62. PubMed PMID: 25715737.

Wang Y, Fan X, Zhang W, Zhang C, Wang J, Jiang T, Wang L. Deficiency of very large G-protein-coupled receptor-1 is a risk factor of tumor-related epilepsy: a whole transcriptome sequencing analysis. J Neurooncol. 2015 Feb;121(3):609-16. PubMed PMID: 25511798.

Petersen SC, Luo R, Liebscher I, Giera S, Jeong SJ, Mogha A, Ghidinelli M, Feltri ML, Schöneberg T, Piao X, Monk KR. The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with Laminin-211. Neuron. 2015 Feb 18;85(4):755-69. PubMed PMID: 25695270.

Xu JF, Yang GH, Pan XH, Zhang SJ, Zhao C, Qiu BS, Gu HF, Hong JF, Cao L, Chen Y, Xia B, Bi Q, Wang YP. Association of GPR126 gene polymorphism with adolescent idiopathic scoliosis in Chinese populations. Genomics. 2015 Feb;105(2):101-7. PubMed PMID: 25479386.

He Z, Wu H, Jiao Y, Zheng J. Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer. Oncol Lett. 2015 Feb;9(2):793-797. PubMed PMID: 25624904.

Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR. The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα(12/13) and RhoA. Nat Commun. 2015 Jan 21;6:6122. PubMed PMID: 25607772.

Giera S, Deng Y, Luo R, Ackerman SD, Mogha A, Monk KR, Ying Y, Jeong SJ, Makinodan M, Bialas AR, Chang BS, Stevens B, Corfas G, Piao X. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015 Jan 21;6:6121.

Solaimani Kartalaei P, Yamada-Inagawa T, Vink CS, de Pater E, van der Linden R, Marks-Bluth J, van der Sloot A, van den Hout M, Yokomizo T, van Schaick-Solernó ML, Delwel R, Pimanda JE, van IJcken WF, Dzierzak E. Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation. J Exp Med. 2015 Jan 12;212(1):93-106. PubMed PMID: 25547674.

2014

Liebscher I, Schön J, Petersen SC, Fischer L, Auerbach N, Demberg LM, Mogha A, Cöster M, Simon KU, Rothemund S, Monk KR, Schöneberg T. A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133. Cell Rep. 2014 Dec 24;9(6):2018-26. PubMed PMID: 25533341.

Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014 Dec;1333(1):43-64. PubMed PMID: 25424900.

Wang XJ, Zhang DL, Xu ZG, Ma ML, Wang WB, Li LL, Han XL, Huo Y, Yu X, Sun JP. Understanding cadherin EGF LAG seven-pass G-type receptors. J Neurochem. 2014 Dec;131(6):699-711. PubMed PMID: 25280249.

Favara DM, Banham AH, Harris AL. A review of ELTD1, a pro-angiogenic adhesion GPCR. Biochem Soc Trans. 2014 Dec 1;42(6):1658-64. PubMed PMID: 25399586.

Yang TY, Chiang NY, Tseng WY, Pan HL, Peng YM, Shen JJ, Wu KA, Kuo ML, Chang GW, Lin HH. Expression and immunoaffinity purification of recombinant soluble human GPR56 protein for the analysis of GPR56 receptor shedding by ELISA. Protein Expr Purif. 2014 Nov 28. pii: S1046-5928(14)00274-5. PubMed PMID: 25437104.

White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM. G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15756-61. PubMed PMID: 25336758.

Hsiao CC, Wang WC, Kuo WL, Chen HY, Chen TC, Hamann J, Lin HH. CD97 inhibits cell migration in human fibrosarcoma cells by modulating TIMP-2/MT1- MMP/MMP-2 activity – role of GPS autoproteolysis and functional cooperation between the N- and C-terminal fragments. FEBS J. 2014 Nov;281(21):4878-91. PubMed PMID: 25174588.

Zhou Y, Nathans J. Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling. Dev Cell. 2014 Oct 27;31(2):248-56. PubMed PMID: 25373781.

Jia Z, Guo Y, Tang Y, Xu Q, Li B, Wu Q. Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity. Mol Cell Biol. 2014 Oct;34(20):3895-910. PubMed PMID: 25113559

Chai G, Zhou L, Manto M, Helmbacher F, Clotman F, Goffinet AM, Tissir F. Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nat Neurosci. 2014 Sep;17(9):1171-9. PubMed PMID: 25108913.

Hu QX, Dong JH, Du HB, Zhang DL, Ren HZ, Ma ML, Cai Y, Zhao TC, Yin XL, Yu X, Xue T, Xu ZG, Sun JP. Constitutive Gαi coupling activity of VLGR1 and its regulation by PDZD7. J Biol Chem. 2014 Aug 29;289(35):24215-25. PubMed PMID: 24962568.

Paavola KJ, Sidik H, Zuchero JB, Eckart M, Talbot WS. Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126. Sci Signal. 2014 Aug 12;7(338):ra76. PubMed PMID: 25118328.

Boutin C, Labedan P, Dimidschstein J, Richard F, Cremer H, André P, Yang Y, Montcouquiol M, Goffinet AM, Tissir F. A dual role for planar cell polarity genes in ciliated cells. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3129-38. PubMed PMID: 25024228.

Qu Y, Huang Y, Feng J, Alvarez-Bolado G, Grove EA, Yang Y, Tissir F, Zhou L, Goffinet AM. Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2996-3004. PubMed PMID: 25002511.

Zyryanova T, Schneider R, Adams V, Sittig D, Kerner C, Gebhardt C, Ruffert H, Glasmacher S, Hepp P, Punkt K, Neuhaus J, Hamann J, Aust G. Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function. PLoS One. 2014 Jun 20;9(6):e100513. PubMed PMID: 24949957.

Luo R, Jeong SJ, Yang A, Wen M, Saslowsky DE, Lencer WI, Arac D, Piao X. Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation. PLoS One. 2014 Jun 20;9(6):e100043. PubMed PMID: 24949629.

Mazaheri F, Breus O, Durdu S, Haas P, Wittbrodt J, Gilmour D, Peri F. Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia. Nat Commun. 2014 Jun 5;5:4046. PubMed PMID: 24898390.

Yang J, Wang Z, Leng D, Dai H, Wang J, Liang J, Jiang D, Wang C. G protein-coupled receptor 56 regulates matrix production and motility of lung fibroblasts. Exp Biol Med (Maywood). 2014 Jun;239(6):686-96. PubMed PMID: 25513275.

Fujii Y, Ishikawa N, Kobayashi Y, Kobayashi M, Kato M. Compound heterozygosity in GPR56 with bilateral frontoparietal polymicrogyria. Brain Dev. 2014 Jun;36(6):528-31. PubMed PMID: 23981349.

Wang Y, Cho SG, Wu X, Siwko S, Liu M. G-protein coupled receptor 124 (GPR124) in endothelial cells regulates vascular endothelial growth factor (VEGF)-induced tumor angiogenesis. Curr Mol Med. 2014 May;14(4):543-54. PubMed PMID: 24730523.

Legrand F, Tomasevic N, Simakova O, Richard Lee CC, Wang Z, Raffeld M, Makiya MA, Palath V, Leung J, Baer M, Yarranton G, Maric I, Bebbington C, Klion AD. The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): A novel therapeutic target for eosinophilic disorders. J Allergy Clin Immunol. 2014 May;133(5):1439-1447.e8. PubMed PMID: 24530099.

Stephenson JR, Purcell RH, Hall RA. The BAI subfamily of adhesion GPCRs: synaptic regulation and beyond. Trends Pharmacol Sci. 2014 Apr;35(4):208-215. PubMed PMID: 24642458.

Lei Y, Zhu H, Yang W, Ross ME, Shaw GM, Finnell RH. Identification of novel CELSR1 mutations in spina bifida. PLoS One. 2014 Mar 14;9(3):e92207. PubMed PMID: 24632739.

Yang J, Wang Z, Leng D, Dai H, Wang J, Liang J, Jiang D, Wang C. G protein-coupled receptor 56 regulates matrix production and motility of lung fibroblasts. Exp Biol Med (Maywood). 2014 Apr 17;239(6):686-696. PubMed PMID: 24742924.

Hamoud N, Tran V, Croteau LP, Kania A, Coté JF. G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3745-50. PubMed PMID: 24567399.

Lu YY, Sweredoski MJ, Huss D, Lansford R, Hess S, Tirrell DA. Prometastatic GPCR CD97 is a direct target of tumor suppressor microRNA-126. ACS Chem Biol. 2014 Feb 21;9(2):334-8. PubMed PMID: 24274104.

Yang L, Friedland SC, Corson N, Xu L. GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2. Cancer Res. 2014 Feb 15;74(4):1022-31. PubMed PMID: 24356421.

Bae BI, Tietjen I, Atabay KD, Evrony GD, Johnson MB, Asare E, Wang PP, Murayama AY, Im K, Lisgo SN, Overman L, Sestan N, Chang BS, Barkovich AJ, Grant PE, Topçu M, Politsky J, Okano H, Piao X, Walsh CA. Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science. 2014 Feb 14;343(6172):764-8. PubMed PMID: 24531968.

Huang LC, Hueng DY. CD97 and glioma invasion. J Neurosurg. 2014 Feb;120(2):579-80. PubMed PMID: 24286141.

Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, Dang SY, Zhang GH, Zhang HX, Kuang Y, Fei J, Gu MM, Rong WF, Wang ZG. Deletion of Gpr128 results in weight loss and increased ininal contraction frequency. World J Gastroenterol. 2014 Jan 14;20(2):498-508. PubMed PMID: 24574718.

2013

Simundza J, Cowin P. Adhesion G-protein-coupled receptors: elusive hybrids come of age. Cell Commun Adhes. 2013 Dec;20(6):213-25. PubMed PMID: 24229322.

Valtcheva N, Primorac A, Jurisic G, Hollmen M, Detmar M. The orphan adhesion G protein coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. J Biol Chem. 2013 Dec 13;288(50):35736-48. PubMed PMID: 24178298.

Wu MP, Doyle JR, Barry B, Beauvais A, Rozkalne A, Piao X, Lawlor MW, Kopin AS, Walsh CA, Gussoni E. GPR56 promotes myoblast fusion through SRE- and NFAT-mediated signaling but is not essential for muscle development in vivo. FEBS J. 2013 Dec;280(23):6097-113. PubMed PMID: 24102982.

Shin D, Lin ST, Fu YH, Ptácek LJ. Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19101-6. PubMed PMID: 24191038.

Mogha A, Benesh AE, Patra C, Engel FB, Schöneberg T, Liebscher I, Monk KR. Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation. J Neurosci. 2013 Nov 13;33(46):17976-85. PubMed PMID: 24227709.

Geng FS, Abbas L, Baxendale S, Holdsworth CJ, Swanson AG, Slanchev K, Hammerschmidt M, Topczewski J, Whitfield TT. Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development. 2013 Nov;140(21):4362-74. PubMed PMID: 24067352.

Park SJ, Lee KP, Kang S, Chung HY, Bae YS, Okajima F, Im DS. Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer cells. Cell Signal. 2013 Nov;25(11):2147-54. PubMed PMID: 23838008.

Tang X, Jin R, Qu G, Wang X, Li Z, Yuan Z, Zhao C, Siwko S, Shi T, Wang P, Xiao J, Liu M, Luo J. GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Gαq-p63RhoGEF-Rho GTPase pathway. Cancer Res. 2013 Oct 15;73(20):6206-18. PubMed PMID: 24008316.

Wang JJ, Zhang LL, Zhang HX, Shen CL, Lu SY, Kuang Y, Wan YH, Wang WG, Yan HM, Dang SY, Fei J, Jin XL, Wang ZG. Gpr97 is essential for the follicular versus marginal zone B-lymphocyte fate decision. Cell Death Dis. 2013 Oct 10;4:e853. PubMed PMID: 24113187.

Patra C, van Amerongen MJ, Ghosh S, Ricciardi F, Sajjad A, Novoyatleva T, Mogha A, Monk KR, Mühlfeld C, Engel FB. Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16898-903. PubMed PMID: 24082093.

Bridges JP, Ludwig MG, Mueller M, Kinzel B, Sato A, Xu Y, Whitsett JA, Ikegami M. Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size. Am J Respir Cell Mol Biol. 2013 Sep;49(3):348-57. PubMed PMID: 23590306.

Saito Y, Kaneda K, Suekane A, Ichihara E, Nakahata S, Yamakawa N, Nagai K, Mizuno N, Kogawa K, Miura I, Itoh H, Morishita K. Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56. Leukemia. 2013 Aug;27(8):1637-49. PubMed PMID: 23478665.

Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, Mangala LS, Wu SY, Pradeep S, Li D, Han C, Dalton H, Lopez-Berestein G, Tuynman JB, Mortensen N, Li JL, Patient R, Sood AK, Banham AH, Harris AL, Buffa FM. A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. Cancer Cell. 2013 Aug 12;24(2):229-41. PubMed PMID: 23871637.

Stephenson JR, Paavola KJ, Schaefer SA, Kaur B, Van Meir EG, Hall RA. Brain-specific angiogenesis inhibitor-1 signaling, regulation and enrichment in the postsynaptic density. J Biol Chem. 2013 Aug 2;288(31):22248-56. PubMed PMID: 23782696.

Prömel S, Langenhan T, Araç D. Matching structure with function: the GAIN domain of Adhesion-GPCR and PKD1-like proteins. Trends Pharmacol Sci. 2013 Aug;34(8):470-8. PubMed PMID: 23850273.

Glenn TD, Talbot WS. Analysis of Gpr126 function defines distinct mechanisms controlling the initiation and maturation of myelin. Development. 2013 Aug;140(15):3167-75. PubMed PMID: 23804499.

Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, Isope P, Vodjdani G, Heintz N, Selimi F. The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons. Mol Psychiatry. 2013 Aug;18(8):943-50. PubMed PMID: 23628982.

Liebscher I, Schöneberg T, Prömel S. Progress in demystification of adhesion G protein-coupled receptors. Biol Chem. 2013 Aug 1;394(8):937-50. PubMed PMID: 23518449.

Li X, Roszko I, Sepich DS, Ni M, Hamm HE, Marlow FL, Solnica-Krezel L. Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Development. 2013 Jul;140(14):3028-39. PubMed PMID: 23821037.

Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S. Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D. PLoS One. 2013 Jul 29;8(7):e69451. PubMed PMID: 23922714.

Jeong SJ, Luo R, Singer K, Giera S, Kreidberg J, Kiyozumi D, Shimono C, Sekiguchi K, Piao X. GPR56 functions together with α3β1 integrin in regulating cerebral cortical development. PLoS One. 2013 Jul 9;8(7):e68781. PubMed PMID: 23874761.

Aust G, Kerner C, Gonsior S, Sittig D, Schneider H, Buske P, Scholz M, Dietrich N, Oldenburg S, Karpus ON, Galle J, Amasheh S, Hamann J. Mice overexpressing CD97 in ininal epithelial cells provide a unique model for mammalian postnatal ininal cylindrical growth. Mol Biol Cell. 2013 Jul;24(14):2256-2268. PubMed PMID: 23676664.

Kou I, Takahashi Y, Johnson TA, Takahashi A, Guo L, Dai J, Qiu X, Sharma S, Takimoto A, Ogura Y, Jiang H, Yan H, Kono K, Kawakami N, Uno K, Ito M, Minami S, Yanagida H, Taneichi H, Hosono N, Tsuji T, Suzuki T, Sudo H, Kotani T, Yonezawa I, Londono D, Gordon D, Herring JA, Watanabe K, Chiba K, Kamatani N, Jiang Q, Hiraki Y, Kubo M, Toyama Y, Tsunoda T, Wise CA, Qiu Y, Shukunami C, Matsumoto M, Ikegawa S. Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis. Nat Genet. 2013 Jun;45(6):676-9. PubMed PMID: 23666238.

Southern C, Cook JM, Neetoo-Isseljee Z, Taylor DL, Kettleborough CA, Merritt A, Bassoni DL, Raab WJ, Quinn E, Wehrman TS, Davenport AP, Brown AJ, Green A, Wigglesworth MJ, Rees S. Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609. PubMed PMID: 23396314.

Fallgatter AJ, Ehlis AC, Dresler T, Reif A, Jacob CP, Arcos-Burgos M, Muenke M, Lesch KP. Influence of a Latrophilin 3 (LPHN3) risk haplotype on event-related potential measures of cognitive response control in attention-deficit hyperactivity disorder (ADHD). Eur Neuropsychopharmacol. 2013 Jun;23(6):458-68. PubMed PMID: 23245769.

Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B. Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116. Cell Rep. 2013 May 30;3(5):1457-64. PubMed PMID: 23684610.

Ward Y, Lake R, Martin PL, Killian K, Salerno P, Wang T, Meltzer P, Merino M, Cheng SY, Santoro M, Garcia-Rostan G, Kelly K. CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model. Oncogene. 2013 May 30;32(22):2726-38. PubMed PMID: 22797060.22797060.

Langenhan T, Aust G, Hamann J. Sticky signaling–adhesion class G protein-coupled receptors take the stage. Sci Signal. 2013 May 21;6(276):re3. PubMed PMID: 23695165.

Wang W, DA R, Wang M, Wang T, Qi L, Jiang H, Chen W, Li Q. Expression of brain-specific angiogenesis inhibitor 1 is inversely correlated with pathological grade, angiogenesis and peritumoral brain edema in human astrocytomas. Oncol Lett. 2013 May;5(5):1513-1518. PubMed PMID: 23761815.

Hochreiter-Hufford AE, Lee CS, Kinchen JM, Sokolowski JD, Arandjelovic S, Call JA, Klibanov AL, Yan Z, Mandell JW, Ravichandran KS. Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature. 2013 May 9;497(7448):263-7. PubMed PMID: 23615608.

Richter GH, Fasan A, Hauer K, Grunewald TG, Berns C, Rössler S, Naumann I, Staege MS, Fulda S, Esposito I, Burdach S. G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1. J Pathol. 2013 May;230(1):70-81. PubMed PMID: 23338946.

Huarcaya Najarro E, Ackley BD. C. elegans fmi-1/flamingo and Wnt pathway components interact genetically to control the anteroposterior neurite growth of  the VD GABAergic neurons. Dev Biol. 2013 May 1;377(1):224-35. PubMed PMID: 23376536.

Sun JP, Li R, Ren HZ, Xu AT, Yu X, Xu ZG. The very large G protein coupled receptor (Vlgr1) in hair cells. J Mol Neurosci. 2013 May;50(1):204-14. PubMed PMID: 23180093

Duman JG, Tzeng CP, Tu YK, Munjal T, Schwechter B, Ho TS, Tolias KF. The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites. J Neurosci. 2013 Apr 17;33(16):6964-78. PubMed PMID: 23595754.

Karpus ON, Veninga H, Hoek RM, Flierman D, van Buul JD, Vandenakker CC, Vanbavel E, Medof ME, van Lier RA, Reedquist KA, Hamann J. Shear stress-dependent downregulation of the Adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55. J Immunol. 2013 Apr 1;190(7):3740-8. PubMed PMID: 23447688.

García-García G, Besnard T, Baux D, Vaché C, Aller E, Malcolm S, Claustres M, Millan JM, Roux AF. The contribution of GPR98 and DFNB31 genes to a Spanish Usher syndrome type 2 cohort. Mol Vis. 2013;19:367-73. PubMed PMID: 23441107.

Quattrocchi CC, Zanni G, Napolitano A, Longo D, Cordelli DM, Barresi S, Randisi F, Valente EM, Verdolotti T, Genovese E, Specchio N, Vitiello G, Spiegel R, Bertini E, Bernardi B. Conventional magnetic resonance imaging and diffusion tensor imaging studies in children with novel GPR56 mutations: further delineation of a cobblestone-like phenotype. Neurogenetics. 2013 Feb;14(1):77-83. PubMed PMID: 23274687.

Singer K, Luo R, Jeong SJ, Piao X. GPR56 and the developing cerebral cortex: Cells, matrix, and neuronal migration. Mol Neurobiol. 2013 Feb;47(1):186-96. PubMed PMID: 23001883.

Towner RA, Jensen RL, Colman H, Vaillant B, Smith N, Casteel R, Saunders D, Gillespie DL, Silasi-Mansat R, Lupu F, Giles CB, Wren JD. ELTD1, a potential new biomarker for gliomas. Neurosurgery. 2013 Jan;72(1):77-91. PubMed PMID: 23096411.

2012

Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T. Dissecting signaling and functions of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2012 Dec;1276(1):1-25. PubMed PMID: 23215895.

Cork SM, Kaur B, Devi NS, Cooper L, Saltz JH, Sandberg EM, Kaluz S, Van Meir EG. A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1. Oncogene. 2012 Dec 13;31(50):5144-52. PubMed PMID: 22330140.

Weinsheimer S, Brettman AD, Pawlikowska L, Wu DC, Mancuso MR, Kuhnert F, Lawton MT, Sidney S, Zaroff JG, McCulloch CE, Young WL, Kuo C, Kim H. G protein-coupled receptor 124 (GPR124) gene polymorphisms and risk of brain arteriovenous malformation. Transl Stroke Res. 2012 Dec;3(4):418-427. PubMed PMID: 23329986.

Paavola KJ, Hall RA. Adhesion g protein-coupled receptors: signaling, pharmacology, and mechanisms of activation. Mol Pharmacol. 2012 Nov;82(5):777-83. PubMed PMID: 22821233

Nie T, Hui X, Gao X, Li K, Lin W, Xiang X, Ding M, Kuang Y, Xu A, Fei J, Wang Z, Wu D. Adipose tissue deletion of Gpr116 impairs insulin sensitivity through modulation of adipose function. FEBS Lett. 2012 Oct 19;586(20):3618-25. PubMed PMID: 22971422.

Feng J, Xu Y, Wang M, Ruan Y, So KF, Tissir F, Goffinet A, Zhou L. A role for atypical cadherin celsr3 in hippocampal maturation and connectivity. J Neurosci. 2012 Oct 3;32(40):13729-43. PubMed PMID: 23035085.

Prömel S, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Grosse J, Schöneberg T, Russ AP, Langenhan T. Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Dev Dyn. 2012 Oct;241(10):1591-602. PubMed PMID: 22837050.

Badiali L, Cedernaes J, Olszewski PK, Nylander O, Vergoni AV, Schiöth HB. Adhesion GPCRs are widely expressed throughout the subsections of the gastroininal tract. BMC Gastroenterol. 2012 Sep 25;12(1):134. PubMed PMID: 23009096.

Lange M, Norton W, Coolen M, Chaminade M, Merker S, Proft F, Schmitt A, Vernier P, Lesch KP, Bally-Cuif L. The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development. Mol Psychiatry. 2012 Sep;17(9):946-54. PubMed PMID: 22508465.

Jeong SJ, Luo R, Li S, Strokes N, Piao X. Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex. J Comp Neurol. 2012 Sep 1;520(13):2930-40. PubMed PMID: 22351047.

Prömel S, Frickenhaus M, Hughes S, Mestek L, Staunton D, Woollard A, Vakonakis I, Schöneberg T, Schnabel R, Russ AP, Langenhan T. The GPS motif is a molecular switch for bimodal activities of adhesion class G protein-coupled receptors. Cell Rep. 2012 Aug 30;2(2):321-31. PubMed PMID: 22938866.

Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T, Li L. Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell. 2012 Jul 20;150(2):351-65. PubMed PMID: 22817897.

Liu D, Trojanowicz B, Ye L, Li C, Zhang L, Li X, Li G, Zheng Y, Chen L. The invasion and metastasis promotion role of CD97 small isoform in gastric carcinoma. PLoS One. 2012;7(6):e39989. PubMed PMID: 22768192.

Xiao J, Jiang H, Zhang R, Fan G, Zhang Y, Jiang D, Li H. Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1. PLoS One. 2012;7(5):e35779. PubMed PMID: 22606234.

Nishimura T, Honda H, Takeichi M. Planar cell polarity links axes of spatial dynamics in neural-tube closure. Cell. 2012 May 25;149(5):1084-97. PubMed PMID: 22632972.

Chan YF, Jones FC, McConnell E, Bryk J, Bünger L, Tautz D. Parallel selection mapping using artificially selected mice reveals body weight control loci. Curr Biol. 2012 May 8;22(9):794-800. PubMed PMID: 22445301.

Yang L, Xu L. GPR56 in cancer progression: current status and future perspective. Future Oncol. 2012 Apr;8(4):431-40. Review. PubMed PMID: 22515446.

Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X. Signaling property study of adhesion G-protein-coupled receptors. FEBS Lett. 2012 Apr 24;586(8):1214-9. PubMed PMID: 22575658.

Huang YS, Chiang NY, Hu CH, Hsiao CC, Cheng KF, Tsai WP, Yona S, Stacey M, Gordon S, Chang GW, Lin HH. Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains. Mol Cell Biol. 2012 Apr;32(8):1408-20. PubMed PMID: 22310662.

Najarro EH, Wong L, Zhen M, Carpio EP, Goncharov A, Garriga G, Lundquist EA, Jin Y, Ackley BD. Caenorhabditis elegans flamingo cadherin fmi-1 regulates GABAergic neuronal development. J Neurosci. 2012 Mar 21;32(12):4196-211. PubMed PMID: 22442082.

Boucard AA, Ko J, Südhof TC. High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex. J Biol Chem. 2012 Mar 16;287(12):9399-413. PubMed PMID: 22262843.

O’Sullivan ML, de Wit J, Savas JN, Comoletti D, Otto-Hitt S, Yates JR 3rd, Ghosh A. FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. Neuron. 2012 Mar 8;73(5):903-10. PubMed PMID: 22405201.

Tesmer JJ. A GAIN in understanding autoproteolytic G protein-coupled receptors and polycystic kidney disease proteins. EMBO J. 2012 Mar 21;31(6):1334-5. PubMed PMID: 22388517.

Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT. A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J. 2012 Feb 14;31(6):1364-78. PubMed PMID: 22333914.

Vallon M, Aubele P, Janssen KP, Essler M. Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase. Biochem J. 2012 Feb 1;441(3):937-44. PubMed PMID:
22013897.

Luo R, Jin Z, Deng Y, Strokes N, Piao X. Disease-associated mutations prevent GPR56-collagen III interaction. PLoS One. 2012;7(1):e29818. PubMed PMID: 22238662.

Krishnan A, Almén MS, Fredriksson R, Schiöth HB. The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi. PLoS One. 2012;7(1):e29817. PubMed PMID: 22238661.

2011

Bohnekamp J, Schöneberg T. Cell adhesion receptor GPR133 couples to Gs protein. J Biol Chem. 2011 Dec 9;286(49):41912-6. PubMed PMID: 22025619.

Ward Y, Lake R, Yin JJ, Heger CD, Raffeld M, Goldsmith PK, Merino M, Kelly K. LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells. Cancer Res. 2011 Dec 1;71(23):7301-11. PubMed PMID: 21978933.

Rutkowski MJ, Sughrue ME, Kane AJ, Kim JM, Bloch O, Parsa AT. Epidermal growth factor module-containing mucin-like receptor 2 is a newly identified adhesion G protein-coupled receptor associated with poor overall survival and an invasive phenotype in glioblastoma. J Neurooncol. 2011 Nov;105(2):165-71. PubMed PMID: 21503828.

Peng YM, van de Garde MD, Cheng KF, Baars PA, Remmerswaal EB, van Lier RA, Mackay CR, Lin HH, Hamann J. Specific expression of GPR56 by human cytotoxic lymphocytes. J Leukoc Biol. 2011 Oct;90(4):735-40. PubMed PMID: 21724806.

Veninga H, Hoek RM, de Vos AF, de Bruin AM, An FQ, van der Poll T, van Lier RA, Medof ME, Hamann J. A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense. PLoS One. 2011;6(10):e24431. PubMed PMID: 21984892.

Zhu D, Hunter SB, Vertino PM, Van Meir EG. Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1. Cancer Res. 2011 Sep 1;71(17):5859-70. PubMed PMID: 21724586.

Nordström KJ, Almén MS, Edstam MM, Fredriksson R, Schiöth HB. Independent HHsearch, Needleman-Wunsch-based and motif analyses reveals the overall hierarchy for most of the G protein-coupled receptor families. Mol Biol Evol. 2011 Sep;28(9):2471-80. PubMed PMID: 21402729.

Gordon S, Hamann J, Lin HH, Stacey M. F4/80 and the related adhesion-GPCRs. Eur J Immunol. 2011 Sep;41(9):2472-6. Review. PubMed PMID: 21952799.

Cork SM, Van Meir EG. Emerging roles for the BAI1 protein family in the regulation of phagocytosis, synaptogenesis, neurovasculature, and tumor development. J Mol Med (Berl). 2011 Aug;89(8):743-52. Review. PubMed PMID: 21509575.

Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes RO, Xu L. GPR56 Regulates VEGF production and angiogenesis during melanoma progression. Cancer Res. 2011 Aug 15;71(16):5558-68. PubMed PMID: 21724588.

Sokolowski JD, Nobles SL, Heffron DS, Park D, Ravichandran KS, Mandell JW. Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: implications for its dual function as an apoptotic engulfment receptor. Brain Behav Immun. 2011 Jul;25(5):915-21. PubMed PMID: 20888903.

Silva JP, Lelianova VG, Ermolyuk YS, Vysokov N, Hitchen PG, Berninghausen O, Rahman MA, Zangrandi A, Fidalgo S, Tonevitsky AG, Dell A, Volynski KE, Ushkaryov YA. Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12113-8. PubMed PMID: 21724987.

Monk KR, Oshima K, Jörs S, Heller S, Talbot WS. Gpr126 is essential for peripheral nerve development and myelination in mammals. Development. 2011 Jul;138(13):2673-80. Epub 2011 May 25. PubMed PMID: 21613327.

Izutsu T, Konda R, Sugimura J, Iwasaki K, Fujioka T. Brain-specific angiogenesis inhibitor 1 is a putative factor for inhibition of neovascular formation in renal cell carcinoma. J Urol. 2011 Jun;185(6):2353-8. PubMed PMID: 21511296.

Xiao J, Jiang H, Zhang R, Fan G, Zhang Y, Jiang D, Li H. Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1. PLoS One. 2012;7(5):e35779. PubMed PMID: 22606234.

Chiang NY, Hsiao CC, Huang YS, Chen HY, Hsieh IJ, Chang GW, Lin HH. Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms. J Biol Chem. 2011 Apr 22;286(16):14215-25. PubMed PMID: 21349 848.

Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B. GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64. PubMed PMID: 21421844.

Rani M, Dikhit MR, Sahoo GC, Das P. Comparative domain modeling of human EGF-like module EMR2 and study of interaction of the fourth domain of EGF with chondroitin 4-sulphate. J Biomed Res. 2011 Mar;25(2):100-10. PubMed PMID: 23554678.

Davies JQ, Lin HH, Stacey M, Yona S, Chang GW, Gordon S, Hamann J, Campo L, Han C, Chan P, Fox SB. Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival. Oncol Rep. 2011 Mar;25(3):619-27. PubMed PMID: 21174063.

Veninga H, de Groot DM, McCloskey N, Owens BM, Dessing MC, Verbeek JS, Nourshargh S, van Eenennaam H, Boots AM, Hamann J. CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism. J Leukoc Biol. 2011 Mar;89(3):413-21. PubMed PMID: 21169517.

Ribasés M, Ramos-Quiroga JA, Sánchez-Mora C, Bosch R, Richarte V, Palomar G, Gastaminza X, Bielsa A, Arcos-Burgos M, Muenke M, Castellanos FX, Cormand B, Bayés M, Casas M. Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study. Genes Brain Behav. 2011 Mar;10(2):149-57. PubMed PMID: 21040458.

Anderson KD, Pan L, Yang XM, Hughes VC, Walls JR, Dominguez MG, Simmons MV, Burfeind P, Xue Y, Wei Y, Macdonald LE, Thurston G, Daly C, Lin HC, Economides AN, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gale NW. Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2807-12. PubMed PMID: 21282641.

Bolliger MF, Martinelli DC, Südhof TC. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2534-9. PubMed PMID: 21262840.

Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, Sifri CD, Ravichandran KS, Ernst PB, Casanova JE. Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2136-41. PubMed PMID: 21245295.

Hsiao CC, Chen HY, Chang GW, Lin HH. GPS autoproteolysis is required for CD97 to up-regulate the expression of N-cadherin that promotes homotypic cell-cell aggregation. FEBS Lett. 2011 Jan 21;585(2):313-8. PubMed PMID: 21156175.

Martinez AF, Muenke M, Arcos-Burgos M. From the black widow spider to human behavior: Latrophilins, a relatively unknown class of G protein-coupled receptors, are implicated in psychiatric disorders. Am J Med Genet B Neuropsychiatr Genet. 2011 Jan;156B(1):1-10. PubMed PMID: 21184579.

2010

Hiramatsu H, Tadokoro S, Nakanishi M, Hirashima N. Latrotoxin-induced exocytosis in mast cells transfected with latrophilin. Toxicon. 2010 Dec;56(8):1372-80. PubMed PMID: 20708026.

Chen G, Yang L, Begum S, Xu L. GPR56 is essential for is development and male fertility in mice. Dev Dyn. 2010 Dec;239(12):3358-67. PubMed PMID: 20981830.

Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, Domené S,  Vélez JI, Karkera JD, Balog J, Berg K, Kleta R, Gahl WA, Roessler E, Long R, Lie J, Pineda D, Londono AC, Palacio JD, Arbelaez A, Lopera F, Elia J, Hakonarson H, Johansson S, Knappskog PM, Haavik J, Ribases M, Cormand B, Bayes M, Casas M, Ramos-Quiroga JA, Hervas A, Maher BS, Faraone SV, Seitz C, Freitag CM, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A, Romanos J, Renner T, Jacob C, Lesch KP, Swanson J, Vortmeyer A, Bailey-Wilson JE, Castellanos FX, Muenke M. A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry. 2010 Nov;15(11):1053-66. PubMed PMID: 20157310.

Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science. 2010 Nov 12;330(6006):985-9. PubMed PMID: 21071672.

Serova OV, Popova NV, Petrenko AG, Deyev IE. Association of the subunits of the calcium-independent receptor of α-latrotoxin. Biochem Biophys Res Commun. 2010 Nov 26;402(4):658-62.  PubMed PMID: 20971062.

Waller-Evans H, Prömel S, Langenhan T, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Davies B, Aparicio SA, Grosse J, Russ AP. The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. PLoS One. 2010 Nov 18;5(11):e14047. PubMed PMID: 21124978.

Steimel A, Wong L, Najarro EH, Ackley BD, Garriga G, Hutter H. The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons in C. elegans. Development. 2010 Nov;137(21):3663-73. PubMed PMID: 20876647.

Bahi-Buisson N, Poirier K, Boddaert N, Fallet-Bianco C, Specchio N, Bertini E, Caglayan O, Lascelles K, Elie C, Rambaud J, Baulac M, An I, Dias P, des Portes V, Moutard ML, Soufflet C, El Maleh M, Beldjord C, Villard L, Chelly J. GPR56-related bilateral frontoparietal polymicrogyria: further evidence for an overlap with the cobblestone complex. Brain. 2010 Nov;133(11):3194-209. PubMed PMID: 20929962.

Kane AJ, Sughrue ME, Rutkowski MJ, Phillips JJ, Parsa AT. EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target. Neuroreport. 2010 Nov 17;21(16):1018-22. PubMed PMID: 20827226.

Sokolowski JD, Nobles SL, Heffron DS, Park D,RavichandranKS, Mandell JW. Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: Implications for its dual function as an apoptotic engulfment receptor. Brain Behav Immun. 2010 Oct 1. PubMed PMID: 20888903.

Formstone CJ, Moxon C, Murdoch J, Little P, Mason I. Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein. Mol Cell Neurosci. 2010 Jul;44(3):210-22. PubMed PMID: 20353824.

Han SL, Xu C, Wu XL, Li JL, Liu Z, Zeng QQ. The impact of expressions of CD97 and its ligand CD55 at the invasion front on prognosis of rectal adenocarcinoma.  Int J Colorectal Dis. 2010 Jun;25(6):695-702. PubMed PMID: 20339853.

Okajima D, Kudo G, Yokota H. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. J Recept Signal Transduct Res. 2010 Jun;30(3):143-53. PubMed PMID: 20367554.

Liu D, Trojanowicz B, Radestock Y, Fu T, Hammje K, Chen L, Hoang-Vu C. Role of CD97 isoforms in gastric carcinoma. Int J Oncol. 2010 Jun;36(6):1401-8. PubMed PMID: 20428763.

Yang J, Liu X, Zhao Y, Adamian M, Pawlyk B, Sun X, McMillan DR, Liberman MC, Li T. Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss. PLoS Genet. 2010 May 20;6(5):e1000955. PubMed PMID: 20502675.

Hoek RM, de Launay D, Kop EN, Yilmaz-Elis AS, Lin F, Reedquist KA, Verbeek JS, Medof ME, Tak PP, Hamann J. Deletion of either CD55 or CD97 ameliorates arthritis in mouse models. Arthritis Rheum. 2010 Apr;62(4):1036-42. PubMed PMID: 20131275.

van Eijk M, Aust G, Brouwer MS, van Meurs M, Voerman JS, Dijke IE, Pouwels W, Sändig I, Wandel E, Aerts JM, Boot RG, Laman JD, Hamann J. Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease. Immunol Lett. 2010 Apr 8;129(2):64-71. PubMed PMID: 20167235.

Deyev IE, Petrenko AG. Regulation of CIRL-1 proteolysis and trafficking. Biochimie. 2010 Apr;92(4):418-22. PubMed PMID: 20100540.

Xu L, Begum S, Barry M, Crowley D, Yang L, Bronson RT, Hynes RO. GPR56 plays varying roles in endogenous cancer progression. Clin Exp Metastasis. 2010 Apr;27(4):241-9. PubMed PMID: 20333450.

Ho YH, Lien MT, Lin CM, Wei SY, Chang LH, Hsu JC. Echinoid regulates Flamingo  endocytosis to control ommatidial rotation in the Drosophila eye. Development. 2010 Mar;137(5):745-54. PubMed PMID: 20110316.

Della Chiesa M, Falco M, Parolini S, Bellora F, Petretto A, Romeo E, Balsamo M, Gambarotti M, Scordamaglia F, Tabellini G, Facchetti F, Vermi W, Bottino C, Moretta A, Vitale M. GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues. Int Immunol. 2010 Feb;22(2):91-100. PubMed PMID: 20008459.

Vallon M, Rohde F, Janssen KP, Essler M. Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation. Exp Cell Res. 2010 Feb 1;316(3):412-21. PubMed PMID: 19853600.

Fukushima A, Ishida W, Ojima A, Kajisako M, Sumi T, Yamada J, Tsuru E, Miyazaki J, Tominaga A, Yagita H. Participation of CD11b and F4/