G protein-coupled receptors (GPCRs) from different classes, their structure-function relationships, their signal transduction and physiological functions, and their relevance in inherited diseases are central tropics of the Schöneberg Lab. Specifically, orphan GPCRs of the nucleotide receptor family and the adhesion class are in the current focus. Investigations include classical receptor pharmacology and animal models, but also evolutionary approaches.
Adhesion-GPCRs, as entire class, are considered as orphan GPCRs. Their unique structure suggests specific functions and signal transduction properties. Therefore, unveiling the signal transduction mechanisms of Adhesion-GPCRs is of great interest. We identified G protein-coupling for several Adhesion-GPCR members and currently test activation scenarios. Several animal models (mouse, C. elegans) addressing in vivo functions of Adhesion-GPCR are established in the institute.