MemberTitleInstitutionContact InformationAGPCRsKeywordsTechnologiesWebsite
Brian AckleyPrincipal InvestigatorUniversity of Kansas, USAbdackley@ku.eduFMI-1Neuronal Development, Synaptogenesis, Cell Adhesion, Neurodegeneration, Host/Pathogen interactions, GenomicsGenomics, Confocal Microscopy, Genetics, Biochemistry, Molecular Biology, CRISPR
Haifa AlsharifPhD StudentUniversity of Alabama, Birmingham, USAsaba2323@uab.eduADGRB3
glucose homeostasisWestern Blot, Transfection, Transformation, RNA Isolation, DNA purification, In vivo metabolic measurements in mice, glucose tolerance test, insulin tolerance test, islet isolation, and glucose-stimulated insulin secretion. 
Garret AndersonPrincipal InvestigatorUniversity of California, Riverside, USAgarreta@ucr.eduADGRLs roles of aGPCRs during brain developmentNeural circuit tracing, histology, imaging, electrophysiology
Gabriela AustPrincipal InvestigatorLeipzig University, Germanygabriela.aust@medizin.uni-leipzig.deADGREs
role of aGPCRs in (patho)physiology classical cell and molecular biology, aGPCR-transgenic mice
Patrick BarthPrincipal InvestigatorEPFL, Switzerlandpatrick.barth@epfl.chADGRG1Mechanical responses of aGPCRs/ structure-function of aGPCRs/ adhesion ligand discovery/ design of mechanosensorsprotein structure characterization
protein biochemistry, biophysics
single force spectroscopy
cell signaling
protein design
molecular simulations
Sarah BaxendalePostdoctoral FellowUniversity of Sheffield, inner ear development, drug screeningZebrafish developmental biology, live imaging, in vivo drug screening
Emily BeamanPhD StudentUniversity of Copenhagen, Denmarkemily.beaman@sund.ku.dkADGRA3/GPR125neuroscience, neurodegenerative diseasein vivo work with mice, histology, etc.
Sushant BhatnagarPrincipal InvestigatorUniversity of Alabama, Birmingham, USAsushantbhatnagar@uabmc.eduADGRB3Energy Metabolism, Islet Biology, Insulin Secretion, GPCR Cell Signaling Confocal Imaging, Cell Biology, Physiological 
Beatriz Blanco RedondoPostdoctoral FellowLeipzig University,, Mayo and Remoulade in DrosophilaNeuroscience, disease, aGPCR, gut, DrosophilaWB, PCR, Cloning, imaging, immunoprecipitation, immunohistochemistry
Crisylle BlantonPhD StudentUniversity of California, Riverside, USAcblan008@ucr.eduADGRLsLatrophilins,
Synaptic Assembly, Circuit Development,
Synaptic adhesion molecules
smFISH, Viral Tracing, Electrophysiology, Immunohistochemistry, Fluorescent imaging, Confocal imaging
Anne BormannPhD StudentLeipzig University, Germanyanne.bormann@medizin.uni-leipzig.deCirlprotein-protein interactions, signaling, functionWestern Blotting, (Co-)immunoprecipitation, ELISA, immunohistochemical staining
Antony BoucardPrincipal InvestigatorCinvestav-IPN, Mexico City, Mexicoantony.boucard@cinvestav.mxADGRL1
Molecular basis of synapse formation and function/ Molecular neuro-conectome / Neurobiology of psychiatric disorders / Morphological correlates of aGPCR signaling / Cytoskeleton remodeling and adhesion regulation during cancer progressionBRET-based biosensors, FRET-based biosensors, confocal microscopy, epi-fluorescence microscopy, flow cytometry, recombinant protein expression, receptor binding assays, cell migration assays, cell motility monitoring, pull-down assays, cell culture, immunoblotting, G protein signaling assays, immunocytochemistry, aggregation assays, artificial synapse formation assays (hemisynapses), molecular cloning.
Jim BridgesPrincipal InvestigatorNational Jewish Health, USAbridgesj@njhealth.orgADGRF5pulmonary physiology; pulmonary injury and repair; pulmonary developmenttransgenic animal models, primary cell culture, RNAseq, ATACseq
Max BuhlanMD StudentRudolf Schoenheimer Institute of Biochemistry, Division of General Biochemistry, Germanymax.buhlan@medizin.uni-leipzig.deCirl drosophila; Cirl; Tollo; embryonic developmentgenetics; IHC; light sheet imaging; confocal microscopy
Orkun CevherogluPrincipal InvestigatorStem Cell Institute / Ankara University, Tü, ADGRD1/GPR133, ADGRG5/GPR114, ADGRE2/EMR2Oligomerization in aGPCR family, signaling pathways and downstream interactions in aGPCR familyBRET, FRET, SpIDA, Confocal microscopy, G protein biosensors
Sofia DemolderMaster’s StudentGhent University Hospital – VIB (IRC), Belgiumsofia.demolder@ugent.beADGRG1drug discovery
pharmaceutical target
musculoskeletal diseases
flow cytometry
single cell sequencing
Simon DowellIndustryGSK, UKsimon.j.dowell@gsk.comGeneral interest; history with ADGRE familyDisease linkage, novel drug targets
Joseph DumanResearch FacultyBaylor College of Medicine, USAduman@bcm.eduBAI1Neuronal development
Excitatory synapses
Confocal imaging
Quantitative image analysis
Live imaging
Felix EngelPrincipal InvestigatorFriedrich-Alexander-Universität Erlangen-Nürnberg
Universitätsklinikum Erlangen, Germany
felix.engel@uk-erlangen.deADGRG6Heart, Kidney, BloodZebrafish, Mice, patient samples, RNAscope, all molecular and cellular technologies, hiPSC
Caroline FormstonePrincipal InvestigatorUniversity of Hertfordshire, Hatfield, Hertfordshire, AL10 6AB, ADGRC1Planar cell Polarity, embryonic skin and body wall development, breast cancer3D culture of skin, IHC, in vitro models of breast cancer in 2D and 3D
Alain Garcia De Las BayonasPostdoctoral FellowUC Berkeley, USAalaingdlb@berkeley.eduI am studying a homolog of VLGR1 (shared with animals) and a second aGPCR which is lineage specific (only found in choanoflagellates).aGPCRs , evolution , multicellularitymicroscopy, cell culture, CRISPR/Cas9 genome editing, RNAseq, FACS, Elisa assay, immunostaining, image analysis
Siamon GordonEmeritus Professor of Cellular PathologyUniversity of Oxford, and EMR2, CD97Mouse Macrophage F4/80 ko, Ligands, ECM adhesion, cellular interactions and functions during development and adult.Human EMR2, tissue expression and function. Mouse macrophage wt and F4/80 ko cell lines.
Genetics and phenotypes eg human inborn errors of metabolism, malignancy, immune tolerance
Molecular, cellular and whole animal- including mRNA single cell and spatial expression Human monocyte heterogeneity by FACS.
Randy HallPrincipal InvestigatorEmory University School of Medicine, USArhall3@emory.eduBAI1 (ADGRB1), BAI2 (ADGRB2), GPR56 (ADGRG1)Our research is focused on the activation and regulation of adhesion GPCRs and other receptors expressed in the nervous system.Cell culture, Western blotting, cellular signaling assays, ligand binding assays, immunoprecipitation, high-throughput drug screening, calcium imaging, RNA-seq, proteomics, immunohistochemistry
Jörg HamannPrincipal InvestigatorAmsterdam University Medical Centers
Department of Experimental Immunology, NL
j.hamann@amsterdamumc.nlADGRE1, ADGRE2, ADGRE3, ADGRE4, ADGRE5, ADGRG1, ADGRG3, ADGRG5 neuroimmunology, microglia, T cellsRNAseq, flow cytometry, monoclonal antibodies, transgenic mice, infection models, biobanking, human brain tissue
Cheng-Chih HsiaoPostdoctoral FellowAmsterdam institute for Infection and Immunity
Netherlands Institute for Neuroscience, NL
c.hsiao@amsterdamumc.nlEMR1, EMR2, EMR3, CD97, GPR56, GPR97, and GPR114The function of adhesion GPCRs in the immune systemRNA sequencing, Multicolor flow cytometry, Immunohistochemistry and Immunofluorescence staining
Manuel JankovicPhD StudentCenter for Biotechnology and Biomedicine, Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, DEmanuel.jankovic@bbz.uni-leipzig.deADGRB2 (BAI2), ADGRG3 (GPR97), ADGRD1 (GPR133)protein crystallization and interaction studiesCell culture, transfection, affinity / size-exclusion chromatography, SDS- and Native-PAGE, Western Blot, nanoDSF, Static / Dynamic light scattering, microscale thermophoresis, molecular cloning, X-ray crystallography
Björn KieslichPostdoctoral FellowLeipzig University, DEbjoern.kieslich@bbz.uni-leipzig.dehGPR112, hGPR126, hGPR133, LAT-1 (C. elegans)Structure and function of aGPCR extracellular regionsrecombinant expression in human cell culture, protein purification, native PAGE, dynamic/static light scattering, differential scanning fluorimetry, microscale thermophoresis, surface plasmon resonance, protein crystallography, small-angle X-ray scattering
Hee-Yong KimPrincipal InvestigatorNational Institutes of Health, USAhykim@nih.govGPR110Neurodevelopment, neuroprotectioniPSC cultures, confocal microscopy, mass spectrometry, genomic, metbolomic and proteomic approaches, animal behavioral analysis, transgenic
Marek KörnerPhD StudentLeipzig University, DEmarek.koerner@medizin.uni-leipzig.deCirl (ADGRL)Neurodevelopment, aGPCR, autophagyElectrophysiology, Drosophila, Immunohistology
Abhishek Kumar Singh Master’s StudentIndian Institute of Science Education and Research, Mohali, Indiaabhishekks926@gmail.comGPR56/ADGRG1Molecular Biology, Computational Biology, BioinformaticsMolecular Cloning, Biochemical Assays, Protein Folding, Ligand-Binding Assay, Protein Structure Prediction, Molecular Docking
Emmanouil (Manolis) KyrloglouPhD StudentUniversity Medical Center Groningen (UMCG), NLe.kyrloglou@umcg.nlGPR114 and GPR124Acute Myeloid LeukemiaCell culture, lentiviral overexpression, CRISPR-Cas9
Tobi Langenhan Principal InvestigatorLeipzig University
Rudolf Schönheimer Institute of Biochemistry
Division of General Biochemistry
Medical Faculty, DE
tobii@langenhan-lab.orgADGRL1-3, ADGRG1, ADGRG6, ADGRB1-3, ADGRC, ADGRD1, ADGRF5, Cirl, Fmi, CG11318/Mayo, CG15556/Ketchup, CG15744/Remouladesignaling paradigms, physiological functions in the nervous, immune, cardiovascular and gastrointestinal systems, structure-function relationships, cell non-autonomous effects
Drosophila model, genomic engineering, signaling assays, confocal imaging, quantitative imaging (FRET, super resolution), light-sheet imaging, biochemistry, electrophysiology
Richard Leduc Principal InvestigatorUniversité de Sherbrooke, CArichard.leduc@usherbrooke.caADGRG1, ADGRL3, ADGRE5Structure-function relationship, analysis of variants, cellular signalingHeterologous expression, use of bioluminescent resonance energy transfer (BRET), mutagenesis, cellular models.
Ines LiebscherPrincipal InvestigatorLeipzig University, Medical Faculty, DEines.liebscher@medizin.uni-leipzig.deGPR126, GPR133, GPR114, GPR64, GPR110, GPR115, GPR116, CD97mechano-activation, structure-function-analysis, de-orphanisation, signal transduction, receptor-matrix interaction, adipogenesis, bone functioncell culture, second messenger assays, Western blot, BRET/FRET assays, animal models (mainly mice), mutagenesis, protein expression
Fabian LiessmannPhD StudentInstitute for Drug Discovery – Leipzig University, DEfabian.liessmann@medizin.uni-leipzig.deGPR64, GPR114, GPR126, GPR133, Lat1, Lat3, GPR110Drug Discovery, CADD, Modeling, Screening, Docking, Ultra-large library screeningHomology Modeling, Peptide Docking, Protein-Protein-Docking, Ligand Docking, Screening and MedChem
Hsi-Hsien LinPrincipal InvestigatorChang Gung University,
Immunology, innate immunity, tumorigenesis, signalingFACS, Immune effector function assays, signaling assays, proteomics,r2558.php?Lang=zh-tw,
Dmitrij LjaschenkoPrincipal InvestigatorInstitute for General Biochemistry, Rudolf Schoenheimer Institute of Biochemistry, DEDmitrij.Ljaschenko@medizin.uni-leipzig.deDrosohila CirlaGPCR PhysiologyElectrophysiology
Calcium Imaging
Marie-Gabrielle LudwigIndustryNovartis Pharma AG, CHmarie-gabrielle.ludwig@novartis.comGPR116Physiology of the liver, lipid metabolism
Immunology (innate – macrophages)
aGPCR activation mechanism and modulation of activity
HTRF cAMP, IP1; luciferase assays, calcium transients
molecular biology, crispr
Douglas MacNeilConsultantNew York University, USAzorkbirder@gmail.comADGRD1, ADGRE5GPCR pharmacology, oncology, neurodegeneration, fertilitySecond messenger assays
David MartinelliPrincipal InvestigatorUniversity of Connecticut Health, USAdavidmartinelli@uchc.eduADGRB3synapse, cognition, adhesion, multiple sclerosis molecular genetics, biochemistry, rodent behavior, histology, cell biology
Signe MathiasenPrincipal InvestigatorUniversity of Copenhagen
Department of Biomedical Sciences, DK
Signe.Mathiasen@sund.ku.dkADGRL3In the lab we aim to develop molecular scale tools to study the impact of mechanical stress across ADGRL3.Regular molecular biology techniques
GPCR signaling assays 
Single molecule microscopy
Daniel MatusPostdoctoral FellowStanford University, USAmatus@stanford.eduLatrophilinsNeurodevelopment, Synapse Formation, Neuronal FunctionPrimary neuronal culture, Immunochemistry, Electrophysiology, Live cell imaging, Super Resolution Imaging
Kelly MonkPrincipal InvestigatorOregon Health & Science University, USAmonk@ohsu.eduGpr126, Gpr56Neural development, glial biology, neuron-glial interactions, glial-glial interactionsZebrafish and mouse models
Live imaging
Confocal microscopy
Transmission electron microscopy
Forward and reverse genetics
Johan MustaniemiMaster’s StudentLund University, in aGPCRs related to bone periosteumGastrointestinal tract. Bone. Lymfocyte trafficking. Pediatrics.Clinical research
Anh NguyenPostdoctoral FellowUniversity of California, USAhunganhn@uci.eduADGRG6, ADGRL1Pharmacology, Neurology, GPCRsLigand Binding Assays,  AAV, LTV, sequencing
Kasturi PalPrincipal InvestigatorAshoka University, India kasturi.pal@email.ucr.eduGPR126Trafficking of adhesion GPCRsCell based assays, western blotting, immuno-precipitation, confocal microscopy, BRET
Nicole Perry-HauserPostdoctoral FellowColumbia University, USAnap2164@cumc.columbia.eduADGRL1-3tethered agonism; dopamine regulation; striatum; intracellular signaling; G protein couplingcell-based assays (luciferase gene reporter/BRET); cell imaging (primary culture/immunostaining); ex vivo approaches (electrophysiology); mouse models
Xianhua PiaoPrincipal InvestigatorUniversity of California, San Francisco, USAXianhua.piao@ucsf.eduGPR56/ADGRG1cell-cell interaction, glial biology, brain development, neuroimmune interplay, neurodegenerationmass spectrometry, RNA sequencing, mouse model, organotypic culture, brain organdies
Dimitris PlacantonakisPrincipal InvestigatorNYU Grossman School of Medicine, New York, USAdimitris.placantonakis@nyulangone.orgGPR133, CD97basic mechanisms of activation, ligand discovery, signaling, glioblastomapatient-derived biospecimens, gene editing, biochemistry, proteomics, pharmacology, regulation of expression
Simone Prömel Principal InvestigatorHeinrich Heine University Düsseldorf, Germanyproemel@uni-duesseldorf.deLatrophilin 1 (ADGRL1), Latrophilin 3 (ADGRL3), CELSR (ADGRC), GPR110 (ADGRF1), GPR111 (ADGRF2), GPR115 (ADGRF4)signaling of aGPCR, molecular mechanisms of aGPCR function, translation of signals into physiological functions, aGPCR in cell polarity and division, aGPCR in metabolism cell culture, molecular biology, transgenesis, microscopy (brightfield, fluorecence, confocal…)
Susanne ResslPrincipal InvestigatorThe University of Texas at Austin, USAsuressl@utexas.eduADGRB3ADGRB3 ECD conformation and ligand interaction, ion dependency, proteolytic processing sitesX-ray crystallography, electron microscopy, biochemical and biophysical methods, cell based assays (cell spreading assay)
Farai RoccoMaster’s StudentUniversity of Turin, GPR56Drug design, signalingFRET, molecular docking 
Yanis SaidaniPhD StudentCancer research center of Marseille (CRCM) affiliated to Aix Marseille University, INSERM and CNRS, Francenour-islem-yanis.saidani@inserm.frCELSR2
aGPCR, Breast cancer, MetastasisCell biology, biochemistry, molecular biology, Mass spec, immunofluorescence, live microscopy
Nicole ScholzPrincipal InvestigatorRudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, University Leipzig, Germanyscholzlab@gmail.comLatrophilin-3 (L3), Cirl, GPR116 (F5), CD97 (E5)Biology of aGPCR isoforms, rationale of aGPCR self-cleavage, cell/tissue mechanics, mechanophysiology, nervous system, synaptic functionMolecular biology, Drosophila genetics, immunohistochemistry, behavioral analyses, electrophysiology, Ca2+ Imaging, protein biochemistry 
Elena SeiradakePrincipal InvestigatorUniversity of Oxford,, GPR97Brain developmentstructural biology, cell biology, protein biochemistry
Florian SeufertPhD StudentLeipzig University, Germanyflorian.seufert@medizin.uni-leipzig.deADGRL1, ADGRG2, ADGRB2, ADGRB3, ADGRE2Computational Chemistry, QM/MM, Molecular Docking, Homology Modelling, in silico methods, Mutational AnalysisQM/MM, Molecular Dynamics, Molecular Docking, Homology Modeling, Multivariate Analysis, Multiple Sequence Alignment
Abhishek Kumar SinghMaster’s StudentIndian Institute of Science Education and Research, Mohali, Indiaabhishekks926@gmail.comGPR56/ADGRG1Molecular and Cellular Biology, Pharmacology, Computational BiologyComputational Modelling, Genetic Engineering, Synthetic Biology, Bio-Layer Interferometry, Western Blotting, Liquid Chromatography, Circular Dichroism, etc. 
Katja SpiessSenior ScientistStatens Serum Institut, University of Copenhagen, Department of Biomedical Sciences,; kspiess@sund.ku.dkADGRA1 (GPR123), ADGRA2 (GPR124) and ADGRA3 (GPR125)Virus/aGPCR interactions,, blood brain barrier function, a GPCR signalling, & cleavageIn vitro and & vivo models to study virus/ aGPCR interactions: recombinant mouse models, AAV for specific gene knock down in vivo, broad range of virology methods, qPCR, RNA seq,.TEER experiments, choroid plexus explant as ex vivo models.

Cell based aGPCRs characterization: aGCPR signalling experiments (transcription factor experiments, Ca2+ signalling, Dvl recruitment experiments), qPCR, cell viabiilty experiments, lentivirus transduction for overexpression or knock down of genes, fluorescence microscoopy, tissue culturing , WB and digital PCR.
Norbert SträterPrincipal InvestigatorInstitute of Bioanalytical Chemistry
Leipzig University, Germany
strater@bbz.uni-leipzig.deBAI2, GPR112GAIN domain, ectodomain interactions, structural biologyX-ray crystallography, microthermophoresis
Greg Stinger TallPrincipal InvestigatorUniversity of Michigan, USAgregtall@umich.eduMost of them.Defining the stachel mechanism of AGPCRs, finding probe modulators of AGPCRs, demonstrating shear force activation of AGPCRs in physiological systems. Protein and membrane biochemistry, animal and cell culture models.
Doreen ThorPrincipal InvestigatorLeipzig University, Germanydoreen.thor@medizin.uni-leipzig.deADGRF5aGPCR physiology in metabolic processesmouse phenotyping, insulin determination, cloning, 2nd messenger assays, cell culture
Johanna TiemannPostdoctoral FellowUniversity of Copenhagen, Denmarkjohanna.tiemann@gmail.comall (membrane proteins in general)disease variants, dynamics, functionBioinformatics, MD, Rosetta
Meghana TrivediPrincipal InvestigatorUniversity of Houston, USAmtrivedi@uh.eduADGRF1, ADGRG1cancer, pharmacology, drug discoverycancer biology, GPCR pharmacology, drug discovery
Yuri UshkaryovPrincipal InvestigatorMedway School of Pharmacy, University of Kent, contacts, synaptic transmissionElectrophysiology, calcium fluorescence, mutagenesis, gene knockout, neuronal cell culture
Mario VallonPrincipal InvestigatorUniversity of Würzburg – Institute of Anatomy and Cell Biologymario.vallon@uni-wuerzburg.deGPR124/ADGRA2Blood-brain barrier, endothelial cell biology, Wnt signaling pathwayMouse models, cell culture, molecular biology (CRISPR/Cas9), protein biochemistry, FACS, IF staining, (single cell) RNA-seq
Erwin G Van MeirPrincipal InvestigatorUniversity of Alabama at Birmingham (UAB), USAevanmeir@uab.eduADGRB1, ADGRB3brain cancer, neuro-oncology, cancer signaling, experimental therapeutics, drug discoveryMolecular and cell biology, animal models for cancer
Nemoto WataruPrincipal InvestigatorTokyo Denki University, aGPCRs interacting with GPCRs as well as aGPCRs.Protein-Protein InteractionMachine learning
Tanya WhitfieldPrincipal InvestigatorUniversity of Sheffield, (Gpr126)zebrafish, sensory systems, organogenesis, epithelial morphogenesis, cell signallingZebrafish mutant and transgenic methods, live and fixed fluorescence imaging, CRISPR/Cas9, drug screening, pharmacological manipulation of signalling pathways
Giselle WigginIndustrySosei Heptares, UKgiselle.wiggin@soseiheptares.comGeneral interestStructural biology and drug discoveryProtein Engineering, Structural biology and Drug discovery
Uwe WolfrumPrincipal InvestigatorJohannes Gutenberg University Mainz
Institute of Molecular Physiology
Molecular Cell Biology, Germany
wolfrum@uni-mainz.deVLGR1, ADGRV1photoreceptor cell biology, cilia biology, Usher syndrome, retinal degeneration, intracellular transport, cytoskeleton, focal adhesions, cell motility, pre-mRNA splicing, autophagy, mitochondria-associated ER membranes (MAM), membrane-less organelles, liquid-liquid phase separation  divers protein-protein interaction assays, affinity proteomics, primary cell cultures, life cell imaging, light and electron microscopy, large animal models, … http:/
Jianxiang XuePostdoctoral FellowUniversity of New Mexico, USAJixue@salud.unm.eduGPR56, GPR116Renal physiology and pathophysiologyTransgenic mouse models for whole animal physiology, Immunohistology, in situ hybridization, Flow Cytometry, Western Blotting, ELISA, qRT-PCR, Molecular Cloning
Nathan ZaidmanPrincipal InvestigatorUniversity of New Mexico, USAnzaidman@salud.unm.eduAdgrf1
Renal Physiology, Intercalated Cells, Kidney, Epithelial Physiology, Transcriptional Regulation, Cancer Biologymolecular biology, tissue culture, whole animal physiology, transgenic mice, isolated renal tubules, confocal imaging, calcium imaging
Yimin ZouPrincipal InvestigatorUniversity of California, San Diego, USAyzou@ucsd.eduCelsr3 and Celsr2 (ADGRC2 and ADGRC3)development and function of neuronal synapses and axons in health and diseasesprotein-protein interactions, mass spectrometry, superresolution microscopy, single cell transriptomics, CRISPR-based gene editing, animal behavior, neuroanatomy, electrophysiology, in vivo recording of neural activity in behaving animals, chemogenetics, optogenetics