Members - Adhesion GPCR

Member	Title	Institution	Contact Information	AGPCRs	Keywords	Technologies	Website
Brian Ackley	Principal Investigator	University of Kansas, USA	bdackley@ku.edu	FMI-1	Neuronal Development, Synaptogenesis, Cell Adhesion, Neurodegeneration, Host/Pathogen interactions, Genomics	Genomics, Confocal Microscopy, Genetics, Biochemistry, Molecular Biology, CRISPR	https://molecularbiosciences.ku.edu/people/brian-ackley
Haifa Alsharif	PhD Student	University of Alabama, Birmingham, USA	saba2323@uab.edu	ADGRB3 BAI3	glucose homeostasis	Western Blot, Transfection, Transformation, RNA Isolation, DNA purification, In vivo metabolic measurements in mice, glucose tolerance test, insulin tolerance test, islet isolation, and glucose-stimulated insulin secretion.
Georgiadi Anastasia	Principal Investigator	Institute for Diabetes and Cancer, Helmholtz Centre Munich, Group Endocrine Pharmacology, Germany	anastasia.georgiadi@helmholtz-munich.de	Adgrf5	Adipose tisse remodeling, Endothelial cells and vascular remodeling, Energy expenditure, Obesity, liver steatosis/fibrosis, endocrine and paractine communications,catecholamine resistance, sex dimorphism, GPCRs, singal transduction, preclinical mouse models.	transgenic mouse models, organoids, primary cell immortalisation, Seahorse, Oroboros, mouse indirect calorimetry, injectable recombinant protein production, single cells/nuclei RNAseq, Long reads sequencing, polysome profiling	https://www.helmholtz-munich.de/en/idc/research-groups/endocrine-pharmacology
Garret Anderson	Principal Investigator	University of California, Riverside, USA	garreta@ucr.edu	ADGRLs	roles of aGPCRs during brain development	Neural circuit tracing, histology, imaging, electrophysiology	https://www.andersonlaboratory.org
Demet Araç	Principal Investigator	University of Chicago, USA	arac@uchicago.edu	GAIN domain	structural elements of the aGPCRs	x-ray crystallography, eukaryotic expression of recombinant proteins, biophysical methods	https://arac.uchicago.edu/
Gabriela Aust	Principal Investigator	Leipzig University, Germany	gabriela.aust@medizin.uni-leipzig.de	ADGREs ADGRG1/GPR56 ADGRF4/GPR115	role of aGPCRs in (patho)physiology	classical cell and molecular biology, aGPCR-transgenic mice	https://www.uniklinikum-leipzig.de/einrichtungen/vttg/forschung/experimentelle-chirurgie
Monserrat Avila Zozaya	Postdoctoral Fellow	University of North Carolina, USA	Monserrat_Avila-Zozaya@med.unc.edu	ADGRF5/GPR116 ADGRC1/CELSR1	Cell-cell and cell-matrix interactions, signaling transduction, lymphatic endothelial biology, cytoskeleton remodeling	Primary cell culture, shRNA, BRET biosensors, confocal microscopy, RNAscope, westernblot, qPCR	https://caronlab.web.unc.edu/
Sumit Bandekar	Postdoctoral Fellow	University of Chicago, USA	sjbandekar@uchicago.edu	GPR126, Latrophilin3	Structural biology, cell-based signaling assays, biochemistry	X-ray Crystallography, Cryo-EM, Signaling assays, Biophysical assays, Biochemical assays	https://arac.uchicago.edu/
Patrick Barth	Principal Investigator	EPFL, Switzerland	patrick.barth@epfl.ch	ADGRG1	Mechanical responses of aGPCRs/ structure-function of aGPCRs/ adhesion ligand discovery/ design of mechanosensors	protein structure characterization protein biochemistry, biophysics single force spectroscopy cell signaling protein design molecular simulations
Sarah Baxendale	Postdoctoral Fellow	University of Sheffield, UK	s.baxendale@sheffield.ac.uk	ADGRG6	Zebrafish inner ear development, drug screening	Zebrafish developmental biology, live imaging, in vivo drug screening	https://www.sheffield.ac.uk/biosciences/people/academic-staff/tanya-whitfield
Emily Beaman	PhD Student	University of Copenhagen, Denmark	emily.beaman@sund.ku.dk	ADGRA3/GPR125	neuroscience, neurodegenerative disease	in vivo work with mice, histology, etc.	https://bmi.ku.dk/english/research/molpharm/
Sushant Bhatnagar	Principal Investigator	University of Alabama, Birmingham, USA	sushantbhatnagar@uabmc.edu	ADGRB3	Energy Metabolism, Islet Biology, Insulin Secretion, GPCR Cell Signaling	Confocal Imaging, Cell Biology, Physiological
Beatriz Blanco Redondo	Postdoctoral Fellow	Leipzig University, Germany	bea.blanco.46@gmail.com	Ketchup, Mayo and Remoulade in Drosophila	Neuroscience, disease, aGPCR, gut, Drosophila	WB, PCR, Cloning, imaging, immunoprecipitation, immunohistochemistry
Crisylle Blanton	PhD Student	University of California, Riverside, USA	cblan008@ucr.edu	ADGRLs	Latrophilins, Synaptic Assembly, Circuit Development, Synaptic adhesion molecules	smFISH, Viral Tracing, Electrophysiology, Immunohistochemistry, Fluorescent imaging, Confocal imaging	https://www.andersonlaboratory.org/people
Anne Bormann	PhD Student	Leipzig University, Germany	anne.bormann@medizin.uni-leipzig.de	Cirl	protein-protein interactions, signaling, function	Western Blotting, (Co-)immunoprecipitation, ELISA, immunohistochemical staining
Antony Boucard	Principal Investigator	Cinvestav-IPN, Mexico City, Mexico	antony.boucard@cinvestav.mx	ADGRL1 ADGRL2 ADGRL3	Molecular basis of synapse formation and function/ Molecular neuro-conectome / Neurobiology of psychiatric disorders / Morphological correlates of aGPCR signaling / Cytoskeleton remodeling and adhesion regulation during cancer progression	BRET-based biosensors, FRET-based biosensors, confocal microscopy, epi-fluorescence microscopy, flow cytometry, recombinant protein expression, receptor binding assays, cell migration assays, cell motility monitoring, pull-down assays, cell culture, immunoblotting, G protein signaling assays, immunocytochemistry, aggregation assays, artificial synapse formation assays (hemisynapses), molecular cloning.	https://antonyboucard.wixsite.com/boucard-lab
Jim Bridges	Principal Investigator	National Jewish Health, USA	bridgesj@njhealth.org	ADGRF5	pulmonary physiology; pulmonary injury and repair; pulmonary development	transgenic animal models, primary cell culture, RNAseq, ATACseq	https://www.nationaljewish.org/doctors-departments/providers/researchers/james-p-bridges
Max Buhlan	MD Student	Rudolf Schoenheimer Institute of Biochemistry, Division of General Biochemistry, Germany	max.buhlan@medizin.uni-leipzig.de	Cirl	drosophila; Cirl; Tollo; embryonic development	genetics; IHC; light sheet imaging; confocal microscopy	https://www.langenhan-lab.org
Orkun Cevheroglu	Principal Investigator	Stem Cell Institute / Ankara University, Türkiye	cevheroglu@ankara.edu.tr	ADGRG1/GPR56, ADGRD1/GPR133, ADGRG5/GPR114, ADGRE2/EMR2	Oligomerization in aGPCR family, signaling pathways and downstream interactions in aGPCR family	BRET, FRET, SpIDA, Confocal microscopy, G protein biosensors	https://www.adgrg.org
Kavaljit Chhabra	Principal Investigator	University of Kentucky, USA	kavaljit_chhabra@uky.edu	ADGRL1,2, and 3	Brain, Diabetes, Obesity, Metabolism, Alzheimer’s Disease	Affinity Chromatography, Mass Spectrometry, Stereotaxic Surgery, Transgenic Mouse Models, Ligand / Analyte Binding Assays
Virginea de Araujo Farias	Senior Scientist	University of Alabama, Birmingham, USA	vdearaujofarias@uabmc.edu	ADGRB3	tumorigenesis, cancer progression, therapy resistance, aGPCR, ADGRB3	Cell culture, immunofluorescence, western blots, PCR/qPCR, in vivo tumor models	https://sites.uab.edu/evanmeir/
Sofia Demolder	Master’s Student	Ghent University Hospital – VIB (IRC), Belgium	sofia.demolder@ugent.be	ADGRG1	drug discovery aGPCR pharmaceutical target musculoskeletal diseases	flow cytometry single cell sequencing hisotlogy	https://elewautlab.sites.vib.be/en
Simon Dowell	Industry	GSK, UK	simon.j.dowell@gsk.com	General interest; history with ADGRE family	Disease linkage, novel drug targets
Joseph Duman	Research Faculty	Baylor College of Medicine, USA	duman@bcm.edu	BAI1	Neuronal development Signaling Rho-GTPases Excitatory synapses	Confocal imaging Quantitative image analysis FRET Live imaging Biochemistry Lipids	https://www.bcm.edu/people-search/joseph-duman-20819
Felix Engel	Principal Investigator	Friedrich-Alexander-Universität Erlangen-Nürnberg Universitätsklinikum Erlangen, Germany	felix.engel@uk-erlangen.de	ADGRG6	Heart, Kidney, Blood	Zebrafish, Mice, patient samples, RNAscope, all molecular and cellular technologies, hiPSC	https://www.nephropathologie.uk-erlangen.de/en/ag-engel-exp-renal-and-cardiovascular-research/
David Favara	Postdoctoral Fellow	University of Cambridge, UK	df411@cam.ac.uk	Cancer-associated aGPCRs	Structure-based anti-cancer therapeutic design and development	Both wet lab and computational structural biology methodology
Caroline Formstone	Principal Investigator	University of Hertfordshire, Hatfield, Hertfordshire, AL10 6AB, UK	c.formstone@herts.ac.uk	Celsr1 ADGRC1	Planar cell Polarity, embryonic skin and body wall development, breast cancer	3D culture of skin, IHC, in vitro models of breast cancer in 2D and 3D	https://researchprofiles.herts.ac.uk/portal/en/persons/caroline-formstone(44725625-0ee9-4560-b093-957099f9c019).html
Alain Garcia De Las Bayonas	Postdoctoral Fellow	UC Berkeley, USA	alaingdlb@berkeley.edu	I am studying a homolog of VLGR1 (shared with animals) and a second aGPCR which is lineage specific (only found in choanoflagellates).	aGPCRs , evolution , multicellularity	microscopy, cell culture, CRISPR/Cas9 genome editing, RNAseq, FACS, Elisa assay, immunostaining, image analysis	http://kinglab.berkeley.edu/
Paula Gomez	PhD Student	University of Oxford, UK	paula.gomezcastro@rdm.ox.ac.uk	ADGRL4	intestinal immunity, IBD, vascular remodelling, endothelial cells, gut inflammation, large-scale protein-based assays, ligand-receptor interactions, microbiome, GPCR interactions with extracellular matrix proteins, integrins	In vivo mouse models, recombinant full length ECD protein, recombinant protein production, IHC, IF, light sheet, mass spectrometry, extracellular receptor-ligand interactions using large-scale protein-based approaches	https://www.imm.ox.ac.uk/research/research-groups/simmons-group-intestinal-immunology-lab
Siamon Gordon	Emeritus Professor of Cellular Pathology	University of Oxford, UK	siamon.gordon@path.ox.ac.uk	EMR1(F4/80) and EMR2, CD97	Mouse Macrophage F4/80 ko, Ligands, ECM adhesion, cellular interactions and functions during development and adult.Human EMR2, tissue expression and function. Mouse macrophage wt and F4/80 ko cell lines. Genetics and phenotypes eg human inborn errors of metabolism, malignancy, immune tolerance	Molecular, cellular and whole animal- including mRNA single cell and spatial expression Human monocyte heterogeneity by FACS.
Randy Hall	Principal Investigator	Emory University School of Medicine, USA	rhall3@emory.edu	BAI1 (ADGRB1), BAI2 (ADGRB2), GPR56 (ADGRG1)	Our research is focused on the activation and regulation of adhesion GPCRs and other receptors expressed in the nervous system.	Cell culture, Western blotting, cellular signaling assays, ligand binding assays, immunoprecipitation, high-throughput drug screening, calcium imaging, RNA-seq, proteomics, immunohistochemistry	http://www.pharm.emory.edu/hall
Jörg Hamann	Principal Investigator	Amsterdam University Medical Centers Department of Experimental Immunology, NL	j.hamann@amsterdamumc.nl	ADGRE1, ADGRE2, ADGRE3, ADGRE4, ADGRE5, ADGRG1, ADGRG3, ADGRG5	neuroimmunology, microglia, T cells	RNAseq, flow cytometry, monoclonal antibodies, transgenic mice, infection models, biobanking, human brain tissue
Cheng-Chih Hsiao	Postdoctoral Fellow	Amsterdam institute for Infection and Immunity Netherlands Institute for Neuroscience, NL	c.hsiao@amsterdamumc.nl	EMR1, EMR2, EMR3, CD97, GPR56, GPR97, and GPR114	The function of adhesion GPCRs in the immune system	RNA sequencing, Multicolor flow cytometry, Immunohistochemistry and Immunofluorescence staining
Michael Ivan	Principal Investigator	University of Miami, USA	mivan@med.miami.edu	EMR2, EMR3, CD97	Glioblastoma, Brain Tumor Invasion, Brain Tumor Microenvironment, CD97	Invasion models, In vitro models, mouse models, organoids, excellence, incucyte	https://braintumordoc.com/ivan-lab-members
Manuel Jankovic	PhD Student	Center for Biotechnology and Biomedicine, Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, DE	manuel.jankovic@bbz.uni-leipzig.de	ADGRB2 (BAI2), ADGRG3 (GPR97), ADGRD1 (GPR133)	protein crystallization and interaction studies	Cell culture, transfection, affinity / size-exclusion chromatography, SDS- and Native-PAGE, Western Blot, nanoDSF, Static / Dynamic light scattering, microscale thermophoresis, molecular cloning, X-ray crystallography	https://www.bbz.uni-leipzig.de/en/research/structural-analysis-of-biopolymers
Björn Kieslich	Postdoctoral Fellow	Leipzig University, DE	bjoern.kieslich@bbz.uni-leipzig.de	hGPR112, hGPR126, hGPR133, LAT-1 (C. elegans)	Structure and function of aGPCR extracellular regions	recombinant expression in human cell culture, protein purification, native PAGE, dynamic/static light scattering, differential scanning fluorimetry, microscale thermophoresis, surface plasmon resonance, protein crystallography, small-angle X-ray scattering	https://www.bbz.uni-leipzig.de/forschung/strukturanalytik-von-biopolymeren
Hee-Yong Kim	Principal Investigator	National Institutes of Health, USA	hykim@nih.gov	GPR110	Neurodevelopment, neuroprotection	iPSC cultures, confocal microscopy, mass spectrometry, genomic, metbolomic and proteomic approaches, animal behavioral analysis, transgenic	https://irp.nih.gov/pi/hee-kim
Marek Körner	PhD Student	Leipzig University, DE	marek.koerner@medizin.uni-leipzig.de	Cirl (ADGRL)	Neurodevelopment, aGPCR, autophagy	Electrophysiology, Drosophila, Immunohistology
Abhishek Kumar Singh	Master’s Student	Indian Institute of Science Education and Research, Mohali, India	abhishekks926@gmail.com	GPR56/ADGRG1	Molecular Biology, Computational Biology, Bioinformatics	Molecular Cloning, Biochemical Assays, Protein Folding, Ligand-Binding Assay, Protein Structure Prediction, Molecular Docking
Emmanouil (Manolis) Kyrloglou	PhD Student	University Medical Center Groningen (UMCG), NL	e.kyrloglou@umcg.nl	GPR114 and GPR124	Acute Myeloid Leukemia	Cell culture, lentiviral overexpression, CRISPR-Cas9
Tobi Langenhan	Principal Investigator	Leipzig University Rudolf Schönheimer Institute of Biochemistry Division of General Biochemistry Medical Faculty, DE	tobi@langenhan-lab.org	ADGRL1-3, ADGRG1, ADGRG6, ADGRB1-3, ADGRC, ADGRD1, ADGRF5, Cirl, Fmi, CG11318/Mayo, CG15556/Ketchup, CG15744/Remoulade	signaling paradigms, physiological functions in the nervous, immune, cardiovascular and gastrointestinal systems, structure-function relationships, cell non-autonomous effects	Drosophila model, genomic engineering, signaling assays, confocal imaging, quantitative imaging (FRET, super resolution), light-sheet imaging, biochemistry, electrophysiology	https://www.langenhan-lab.org
Richard Leduc	Principal Investigator	Université de Sherbrooke, CA	richard.leduc@usherbrooke.ca	ADGRG1, ADGRL3, ADGRE5	Structure-function relationship, analysis of variants, cellular signaling	Heterologous expression, use of bioluminescent resonance energy transfer (BRET), mutagenesis, cellular models.
Ines Liebscher	Principal Investigator	Leipzig University, Medical Faculty, DE	ines.liebscher@medizin.uni-leipzig.de	GPR126, GPR133, GPR114, GPR64, GPR110, GPR115, GPR116, CD97	mechano-activation, structure-function-analysis, de-orphanisation, signal transduction, receptor-matrix interaction, adipogenesis, bone function	cell culture, second messenger assays, Western blot, BRET/FRET assays, animal models (mainly mice), mutagenesis, protein expression	https://biochemie.medizin.uni-leipzig.de/mbch_cms/index.php/ag-liebscher
Fabian Liessmann	PhD Student	Institute for Drug Discovery – Leipzig University, DE	fabian.liessmann@medizin.uni-leipzig.de	GPR64, GPR114, GPR126, GPR133, Lat1, Lat3, GPR110	Drug Discovery, CADD, Modeling, Screening, Docking, Ultra-large library screening	Homology Modeling, Peptide Docking, Protein-Protein-Docking, Ligand Docking, Screening and MedChem	https://www.meilerlab.org
Hsi-Hsien Lin	Principal Investigator	Chang Gung University, TW	hhlin@mail.cgu.edu.tw	ADGRE2 ADGRG1 ADGRG3 ADGRG5	Immunology, innate immunity, tumorigenesis, signaling	FACS, Immune effector function assays, signaling assays, proteomics	https://gibms.cgu.edu.tw/p/406-1079-7688,r2558.php?Lang=zh-tw, https://sites.google.com/site/hhlinlab/
Dmitrij Ljaschenko	Principal Investigator	Institute for General Biochemistry, Rudolf Schoenheimer Institute of Biochemistry, DE	Dmitrij.Ljaschenko@medizin.uni-leipzig.de	Drosohila Cirl	aGPCR Physiology	Electrophysiology Calcium Imaging
Marie-Gabrielle Ludwig	Industry	Novartis Pharma AG, CH	marie-gabrielle.ludwig@novartis.com	GPR116	Physiology of the liver, lipid metabolism Immunology (innate – macrophages) aGPCR activation mechanism and modulation of activity	HTRF cAMP, IP1; luciferase assays, calcium transients molecular biology, crispr
Douglas MacNeil	Consultant	New York University, USA	zorkbirder@gmail.com	ADGRD1, ADGRE5	GPCR pharmacology, oncology, neurodegeneration, fertility	Second messenger assays	https://www.linkedin.com/in/douglasmacneil/
David Martinelli	Principal Investigator	University of Connecticut Health, USA	davidmartinelli@uchc.edu	ADGRB3	synapse, cognition, adhesion, multiple sclerosis	molecular genetics, biochemistry, rodent behavior, histology, cell biology	https://health.uconn.edu/synapse/
Signe Mathiasen	Principal Investigator	University of Copenhagen Department of Biomedical Sciences, DK	Signe.Mathiasen@sund.ku.dk	ADGRL3	In the lab we aim to develop molecular scale tools to study the impact of mechanical stress across ADGRL3.	Regular molecular biology techniques GPCR signaling assays BRET FRET Single molecule microscopy	https://bmi.ku.dk/english/research/molpharm/
Daniel Matus	Postdoctoral Fellow	Stanford University, USA	matus@stanford.edu	Latrophilins	Neurodevelopment, Synapse Formation, Neuronal Function	Primary neuronal culture, Immunochemistry, Electrophysiology, Live cell imaging, Super Resolution Imaging	https://med.stanford.edu/sudhoflab.html
Kelly Monk	Principal Investigator	Oregon Health & Science University, USA	monk@ohsu.edu	Gpr126, Gpr56	Neural development, glial biology, neuron-glial interactions, glial-glial interactions	Zebrafish and mouse models Live imaging Confocal microscopy Transmission electron microscopy Forward and reverse genetics	https://www.ohsu.edu/vollum-institute/monk-lab
Ana Lilia Moreno Salinas	Postdoctoral Fellow	Université de Sherbrooke, CAN	mora2426@usherbrooke.ca	ADGRE5, LPHN3, ADGRG1	characterization of aGPCRs signaling pathways	BRET, confocal microscopy, WB, flow cytometry	https://www.researchgate.net/profile/Ana-Moreno-Salinas
Johan Mustaniemi	Master’s Student	Lund University, Sweden	jo8505@student.lu.se	Interested in aGPCRs related to bone periosteum	Gastrointestinal tract. Bone. Lymfocyte trafficking. Pediatrics.	Clinical research
Anh Nguyen	Postdoctoral Fellow	University of California, USA	hunganhn@uci.edu	ADGRG6, ADGRL1	Pharmacology, Neurology, GPCRs	Ligand Binding Assays, AAV, LTV, sequencing
Kasturi Pal	Principal Investigator	Ashoka University, India	kasturi.pal@email.ucr.edu	GPR126	Trafficking of adhesion GPCRs	Cell based assays, western blotting, immuno-precipitation, confocal microscopy, BRET	https://kasturipal.wixsite.com/website
Nicole Perry-Hauser	Postdoctoral Fellow	Columbia University, USA	nap2164@cumc.columbia.edu	ADGRL1-3	tethered agonism; dopamine regulation; striatum; intracellular signaling; G protein coupling	cell-based assays (luciferase gene reporter/BRET); cell imaging (primary culture/immunostaining); ex vivo approaches (electrophysiology); mouse models
Xianhua Piao	Principal Investigator	University of California, San Francisco, USA	Xianhua.piao@ucsf.edu	GPR56/ADGRG1	cell-cell interaction, glial biology, brain development, neuroimmune interplay, neurodegeneration	mass spectrometry, RNA sequencing, mouse model, organotypic culture, brain organdies	http://www.piaolab.org/
Julie Pickett	Research Associate	University of North Carolina, USA	julie.pickett@unc.edu	ADGRG3/GPR97	Probe development, Stachel role, NTF role, Structure determination	in vitro assays (GloSensor, Presto-Tango, TruPath, Ca2+ mobilization), Cryo-EM
Dimitris Placantonakis	Principal Investigator	NYU Grossman School of Medicine, New York, USA	dimitris.placantonakis@nyulangone.org	GPR133, CD97	basic mechanisms of activation, ligand discovery, signaling, glioblastoma	patient-derived biospecimens, gene editing, biochemistry, proteomics, pharmacology, regulation of expression	http://www.placantonakislab.com
Simone Prömel	Principal Investigator	Heinrich Heine University Düsseldorf, Germany	proemel@uni-duesseldorf.de	Latrophilin 1 (ADGRL1), Latrophilin 3 (ADGRL3), CELSR (ADGRC), GPR110 (ADGRF1), GPR111 (ADGRF2), GPR115 (ADGRF4)	signaling of aGPCR, molecular mechanisms of aGPCR function, translation of signals into physiological functions, aGPCR in cell polarity and division, aGPCR in metabolism	cell culture, molecular biology, transgenesis, microscopy (brightfield, fluorecence, confocal…)	https://www.zellbiologie.hhu.de/en/
Susanne Ressl	Principal Investigator	The University of Texas at Austin, USA	suressl@utexas.edu	ADGRB3	ADGRB3 ECD conformation and ligand interaction, ion dependency, proteolytic processing sites	X-ray crystallography, electron microscopy, biochemical and biophysical methods, cell based assays (cell spreading assay)	https://www.ressllab.org
Farai Rocco	Master’s Student	University of Turin, Italy	Rocco.faraci@edu.unito.it	GPR56	Drug design, signaling	FRET, molecular docking
Yanis Saidani	PhD Student	Cancer research center of Marseille (CRCM) affiliated to Aix Marseille University, INSERM and CNRS, France	nour-islem-yanis.saidani@inserm.fr	CELSR2 CELSR1 CELSR3	aGPCR, Breast cancer, Metastasis	Cell biology, biochemistry, molecular biology, Mass spec, immunofluorescence, live microscopy	https://www.crcm-marseille.fr/equipes/equipes-de-recherche/jean-paul-borg/
Nicole Scholz	Principal Investigator	Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, University Leipzig, Germany	scholzlab@gmail.com	Latrophilin-3 (L3), Cirl, GPR116 (F5), CD97 (E5)	Biology of aGPCR isoforms, rationale of aGPCR self-cleavage, cell/tissue mechanics, mechanophysiology, nervous system, synaptic function	Molecular biology, Drosophila genetics, immunohistochemistry, behavioral analyses, electrophysiology, Ca2+ Imaging, protein biochemistry
Elena Seiradake	Principal Investigator	University of Oxford, UK	elena.seiradake@bioch.ox.ac.uk	Latrophilin, GPR97	Brain development	structural biology, cell biology, protein biochemistry	https://seiradake.web.ox.ac.uk/
Florian Seufert	PhD Student	Leipzig University, Germany	florian.seufert@medizin.uni-leipzig.de	ADGRL1, ADGRG2, ADGRB2, ADGRB3, ADGRE2	Computational Chemistry, QM/MM, Molecular Docking, Homology Modelling, in silico methods, Mutational Analysis	QM/MM, Molecular Dynamics, Molecular Docking, Homology Modeling, Multivariate Analysis, Multiple Sequence Alignment	https://proteinformatics.uni-leipzig.de/group/index.php
Abhishek Kumar Singh	Master’s Student	Indian Institute of Science Education and Research, Mohali, India	abhishekks926@gmail.com	GPR56/ADGRG1	Molecular and Cellular Biology, Pharmacology, Computational Biology	Computational Modelling, Genetic Engineering, Synthetic Biology, Bio-Layer Interferometry, Western Blotting, Liquid Chromatography, Circular Dichroism, etc.
Katja Spiess	Senior Scientist	Statens Serum Institut, University of Copenhagen, Department of Biomedical Sciences, Denmark	ktsp@ssi.dk; kspiess@sund.ku.dk	ADGRA1 (GPR123), ADGRA2 (GPR124) and ADGRA3 (GPR125)	Virus/aGPCR interactions,, blood brain barrier function, a GPCR signalling, & cleavage	In vitro and & vivo models to study virus/ aGPCR interactions: recombinant mouse models, AAV for specific gene knock down in vivo, broad range of virology methods, qPCR, RNA seq,.TEER experiments, choroid plexus explant as ex vivo models. Cell based aGPCRs characterization: aGCPR signalling experiments (transcription factor experiments, Ca2+ signalling, Dvl recruitment experiments), qPCR, cell viabiilty experiments, lentivirus transduction for overexpression or knock down of genes, fluorescence microscoopy, tissue culturing , WB and digital PCR.
Hailey Steichen	PhD Student	University of New Mexico, USA	hsteichen@salud.unm.edu	Adgrf5	cell-specific transcript variants	transgenic mice, flow cytometry, snRNAseq
Norbert Sträter	Principal Investigator	Institute of Bioanalytical Chemistry Leipzig University, Germany	strater@bbz.uni-leipzig.de	BAI2, GPR112	GAIN domain, ectodomain interactions, structural biology	X-ray crystallography, microthermophoresis	https://www.bbz.uni-leipzig.de/en/research/structural-analysis-of-biopolymers
Greg Stinger Tall	Principal Investigator	University of Michigan, USA	gregtall@umich.edu	Most of them.	Defining the stachel mechanism of AGPCRs, finding probe modulators of AGPCRs, demonstrating shear force activation of AGPCRs in physiological systems.	Protein and membrane biochemistry, animal and cell culture models.	https://sites.google.com/umich.edu/greg-tall-lab/home
Doreen Thor	Principal Investigator	Leipzig University, Germany	doreen.thor@medizin.uni-leipzig.de	ADGRF5	aGPCR physiology in metabolic processes	mouse phenotyping, insulin determination, cloning, 2nd messenger assays, cell culture	https://biochemie.medizin.uni-leipzig.de/mbch_cms/index.php/ag/ag-thor
Johanna Tiemann	Postdoctoral Fellow	University of Copenhagen, Denmark	johanna.tiemann@gmail.com	all (membrane proteins in general)	disease variants, dynamics, function	Bioinformatics, MD, Rosetta
Douglas Tilley	Principal Investigator	Temple University, USA	douglas.tilley@temple.edu	ADGRF5 (GPR116) ADGRG1 (GPR56)	Cardiovascular pharmacology, heart failure, cardio-immunology	in vivo models of cardiac pathophysiology, transgenic mice, AAV, extracellular vesicles, flow cytometry, IHC, microscopy, FRET, molecular pharmacology	https://medicine.temple.edu/departments-centers/research-centers/aging-cardiovascular-discovery-center/faculty
Meghana Trivedi	Principal Investigator	University of Houston, USA	mtrivedi@uh.edu	ADGRF1, ADGRG1	cancer, pharmacology, drug discovery	cancer biology, GPCR pharmacology, drug discovery
Yuri Ushkaryov	Principal Investigator	Medway School of Pharmacy, University of Kent, UK	y.ushkaryov@kent.ac.uk	ADGRL1	Synaptic contacts, synaptic transmission	Electrophysiology, calcium fluorescence, mutagenesis, gene knockout, neuronal cell culture
Mario Vallon	Principal Investigator	University of Würzburg – Institute of Anatomy and Cell Biology	mario.vallon@uni-wuerzburg.de	GPR124/ADGRA2	Blood-brain barrier, endothelial cell biology, Wnt signaling pathway	Mouse models, cell culture, molecular biology (CRISPR/Cas9), protein biochemistry, FACS, IF staining, (single cell) RNA-seq	https://gepris.dfg.de/gepris/projekt/440925599?language=en
Erwin G Van Meir	Principal Investigator	University of Alabama at Birmingham (UAB), USA	evanmeir@uab.edu	ADGRB1, ADGRB3	brain cancer, neuro-oncology, cancer signaling, experimental therapeutics, drug discovery	Molecular and cell biology, animal models for cancer	https://sites.uab.edu/evanmeir/
Nemoto Wataru	Principal Investigator	Tokyo Denki University, Japan	w.nemoto@mail.dendai.ac.jp	predicted aGPCRs interacting with GPCRs as well as aGPCRs.	Protein-Protein Interaction	Machine learning	https://sites.google.com/site/tdurbcompbio/
Tanya Whitfield	Principal Investigator	University of Sheffield, UK	t.whitfield@sheffield.ac.uk	Adgrg6 (Gpr126)	zebrafish, sensory systems, organogenesis, epithelial morphogenesis, cell signalling	Zebrafish mutant and transgenic methods, live and fixed fluorescence imaging, CRISPR/Cas9, drug screening, pharmacological manipulation of signalling pathways	https://www.sheffield.ac.uk/biosciences/people/academic-staff/tanya-whitfield
Giselle Wiggin	Industry	Sosei Heptares, UK	giselle.wiggin@soseiheptares.com	General interest	Structural biology and drug discovery	Protein Engineering, Structural biology and Drug discovery	https://soseiheptares.com/
Uwe Wolfrum	Principal Investigator	Johannes Gutenberg University Mainz Institute of Molecular Physiology Molecular Cell Biology, Germany	wolfrum@uni-mainz.de	VLGR1, ADGRV1	photoreceptor cell biology, cilia biology, Usher syndrome, retinal degeneration, intracellular transport, cytoskeleton, focal adhesions, cell motility, pre-mRNA splicing, autophagy, mitochondria-associated ER membranes (MAM), membrane-less organelles, liquid-liquid phase separation	divers protein-protein interaction assays, affinity proteomics, primary cell cultures, life cell imaging, light and electron microscopy, large animal models, …	http:/www.ag-wolfrum.bio.uni-mainz.de
Jianxiang Xue	Postdoctoral Fellow	University of New Mexico, USA	Jixue@salud.unm.edu	GPR56, GPR116	Renal physiology and pathophysiology	Transgenic mouse models for whole animal physiology, Immunohistology, in situ hybridization, Flow Cytometry, Western Blotting, ELISA, qRT-PCR, Molecular Cloning
Nathan Zaidman	Principal Investigator	University of New Mexico, USA	nzaidman@salud.unm.edu	Adgrf1 Adgrf5 Adgrg1 Adgrg6	Renal Physiology, Intercalated Cells, Kidney, Epithelial Physiology, Transcriptional Regulation, Cancer Biology	molecular biology, tissue culture, whole animal physiology, transgenic mice, isolated renal tubules, confocal imaging, calcium imaging	https://zaidmanphysiology.com/
Yimin Zou	Principal Investigator	University of California, San Diego, USA	yzou@ucsd.edu	Celsr3 and Celsr2 (ADGRC2 and ADGRC3)	development and function of neuronal synapses and axons in health and diseases	protein-protein interactions, mass spectrometry, superresolution microscopy, single cell transriptomics, CRISPR-based gene editing, animal behavior, neuroanatomy, electrophysiology, in vivo recording of neural activity in behaving animals, chemogenetics, optogenetics	https://biology.ucsd.edu/research/faculty/yzou