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Wang LH, Zhang GL, Liu XY, Peng A, Ren HY, Huang SH, Liu T, Wang XJ. CELSR1 promotes neuroprotection in cerebral ischemic injury mainly through the Wnt/PKC signaling pathway. Int J Mol Sci. 2020 Feb 13;21(4). PubMed PMID: 32070035.

Bruxel EM, Moreira-Maia CR, Akutagava-Martins GC, Quinn TP, Klein M, Franke B, Ribasés M, Rovira P, Sánchez-Mora C, Kappel DB, Mota NR, Grevet EH, Bau CHD, Arcos-Burgos M, Rohde LA, Hutz MH. Meta-analysis and systematic review of ADGRL3 (LPHN3) polymorphisms in ADHD susceptibility. Mol Psychiatry. 2020 Feb 12. PubMed PMID: 32051549.

Bouvier C, Le Loarer F, Macagno N, Aubert S, Audard V, Geneste D, Gomez-Brouchet A, Guinebretière JM, Larousserie F, Pissaloux D, Marie B, Tirode F, Baud J, De Pinieux G. Recurrent novel THBS1-ADGRF5 gene fusion in a new tumor subtype "Acral FibroChondroMyxoid Tumors". Mod Pathol. 2020 Feb 11. PubMed PMID: 32047233.

Cao J, Liu X, Yang Y, Wei B, Li Q, Mao G, He Y, Li Y, Zheng L, Zhang Q, Li J, Wang L, Qi C. Decylubiquinone suppresses breast cancer growth and metastasis by inhibiting angiogenesis via the ROS/p53/BAI1 signaling pathway. Angiogenesis. 2020 Feb 4. PubMed PMID: 32020421.

Bhudia N, Desai S, King N, Ancellin N, Grillot D, Barnes AA, Dowell SJ. G protein-coupling of adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and activation of G protein signalling by an anti-EMR2 antibody. Sci Rep. 2020 Jan 22;10(1):1004. PubMed PMID: 31969668.

Leon K, Cunningham RL, Riback JA, Feldman E, Li J, Sosnick TR, Zhao M, Monk KR, Araç D. Structural basis for adhesion G protein-coupled receptor Gpr126 function. Nat Commun. 2020 Jan 10;11(1):194. PubMed PMID: 31924782.

Jentzsch M, Bill M, Grimm J, Schulz J, Schuhmann L, Brauer D, Goldmann K, Wilke F, Franke GN, Behre G, Pönisch W, Vucinic V, Niederwieser D, Platzbecker U, Schwind S. High expression of the stem cell marker GPR56 at diagnosis identifies acute myeloid leukemia patients at higher relapse risk after allogeneic stem cell transplantation in context with the CD34+/CD38- population. Haematologica. 2020 Jan 9. PubMed PMID: 31919084.

Zalles M, Smith N, Ziegler J, Saunders D, Remerowski S, Thomas L, Gulej R, Mamedova N, Lerner M, Fung KM, Chung J, Hwang K, Jin J, Wiley G, Brown C, Battiste J, Wren JD, Towner RA. Optimized monoclonal antibody treatment against ELTD1 for GBM in a G55 xenograft mouse model. J Cell Mol Med. 2020 Jan;24(2):1738-1749. PubMed PMID: 31863639.

Yu Z, Wang H, Fang Y, Lu L, Li M, Yan B, Nie Y, Teng C. Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6. J Cell Biochem. 2020 Mar;121(3):2318-2329. PubMed PMID: 31692031.

Zhang H, Zhu D, Zhang Z, Kaluz S, Yu B, Devi NS, Olson JJ, Van Meir EG. Correction: EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway. Oncogene. 2020 Jan;39(5):1165. PubMed PMID: 31676871.

Kitakaze T, Yoshikawa M, Kobayashi Y, Kimura N, Goshima N, Ishikawa T, Ogata Y, Yamashita Y, Ashida H, Harada N, Yamaji R. Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56. Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118563. PubMed PMID: 31666191.

Zhang H, Zhu D, Zhang Z, Kaluz S, Yu B, Devi NS, Olson JJ, Van Meir EG. EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway. Oncogene. 2020 Jan;39(5):1041-1048. PubMed PMID: 31582835.

Al Hasan M, Roy P, Dolan S, Martin PE, Patterson S, Bartholomew C. Adhesion G-protein coupled receptor 56 is required for 3T3-L1 adipogenesis. J Cell Physiol. 2020 Feb;235(2):1601-1614. Epub 2019 Jul 15. PubMed PMID: 31304602.


Li J, Shen J, Wang Z, Xu H, Wang Q, Chai S, Fu P, Huang T, Anas O, Zhao H, Li J, Xiong N. ELTD1 facilitates glioma proliferation, migration and invasion by activating JAK/STAT3/HIF-1α signaling axis. Sci Rep. 2019 Sep 25;9(1):13904. PubMed PMID: 31554859.

Rahman MA, Manser C, Benlaouer O, Suckling J, Blackburn JK, Silva JP, Ushkaryov YA. C-terminal phosphorylation of latrophilin-1/ADGRL1 affects the interaction between its fragments. Ann N Y Acad Sci. 2019 Nov;1456(1):122-143. PubMed PMID: 31553068.

Chen DY, Sun NH, Lu YP, Hong LJ, Cui TT, Wang CK, Chen XH, Wang SS, Feng LL, Shi WX, Fukunaga K, Chen Z, Lu YM, Han F. GPR124 facilitates pericyte polarization and migration by regulating the formation of filopodia during ischemic injury. Theranostics. 2019 Aug 14;9(20):5937-5955. PubMed PMID: 31534530.

Bradley EC, Cunningham RL, Wilde C, Morgan RK, Klug EA, Letcher SM, Schöneberg T, Monk KR, Liebscher I, Petersen SC. In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development. Ann N Y Acad Sci. 2019 Nov;1456(1):44-63. PubMed PMID: 31529518.

Azimzadeh P, Talamantez-Lyburn SC, Chang KT, Inoue A, Balenga N. Spatial regulation of GPR64/ADGRG2 signaling by β-arrestins and GPCR kinases. Ann N Y Acad Sci. 2019 Nov;1456(1):26-43. PubMed PMID: 31502283.

Marquardt SA, Wilcox CV, Burns EN, Peterson JA, Finno CJ. Previously identified genetic variants in ADGRL3 are not associated with risk for equine degenerative myeloencephalopathy across breeds. Genes (Basel). 2019 Sep 5;10(9). PubMed PMID: 31491999.

Bassilana F, Nash M, Ludwig MG. Adhesion G protein-coupled receptors: opportunities for drug discovery. Nat Rev Drug Discov. 2019 Nov;18(11):869-884. PubMed PMID: 31462748.

Duman JG, Mulherkar S, Tu YK, Erikson KC, Tzeng CP, Mavratsas VC, Ho TS, Tolias KF. The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest. Elife. 2019 Aug 28;8. PubMed PMID: 31461398.

Zhang S, Chatterjee T, Godoy C, Wu L, Liu QJ, Carmon KS. GPR56 drives colorectal tumor growth and promotes drug resistance through upregulation of MDR1 expression via a RhoA-mediated mechanism. Mol Cancer Res. 2019 Nov;17(11):2196-2207. PubMed PMID: 31444231.

Ahn JI, Yoo JY, Kim TH, Kim YI, Broaddus RR, Ahn JY, Lim JM, Jeong JW. G-protein coupled receptor 64 (GPR64) acts as a tumor suppressor in endometrial cancer. BMC Cancer. 2019 Aug 14;19(1):810. PubMed PMID: 31412816.

Erickson RP, Lai LW, Mustacich DJ, Bernas MJ, Kuo PH, Witte MH. Sex-limited penetrance of lymphedema to females with CELSR1 haploinsufficiency: A second family. Clin Genet. 2019 Nov;96(5):478-482. PubMed PMID: 31403174.

Xiong W, Gao S, Lu Y, Wei L, Mao J, Xie J, Cao Q, Liu J, Bi J, Song X, Li B. Latrophilin participates in insecticide susceptibility through positively regulating CSP10 and partially compensated by OBPC01 in Tribolium castaneum. Pestic Biochem Physiol. 2019 Sep;159:107-117. PubMed PMID: 31400772.

Eichler W, Lohrenz A, Simon KU, Krohn S, Lange J, Bürger S, Liebscher I. The role of ADGRE5/CD97 in human retinal pigment epithelial cell growth and survival. Ann N Y Acad Sci. 2019 Nov;1456(1):64-79. PubMed PMID: 31397926.

Xu S, Wang W, Xu C, Li X, Ye J, Zhu Y, Ge T. ROS1-ADGRG6: a case report of a novel ROS1 oncogenic fusion variant in lung adenocarcinoma and the response to crizotinib. BMC Cancer. 2019 Aug 5;19(1):769. PubMed PMID: 31382924.

Martin GH, Roy N, Chakraborty S, Desrichard A, Chung SS, Woolthuis CM, Hu W, Berezniuk I, Garrett-Bakelman FE, Hamann J, Devlin SM, Chan TA, Park CY. CD97 is a critical regulator of acute myeloid leukemia stem cell function. J Exp Med. 2019 Aug 1. PubMed PMID: 31371381.

Scholz N, Langenhan T, Schöneberg T. Revisiting the classification of adhesion GPCRs. Ann N Y Acad Sci. 2019 Jul 31. PubMed PMID: 31365134.

Wang C, Fan HQ, Zhang YW. MiR-511-5p functions as a tumor suppressor and a predictive of prognosis in colorectal cancer by directly targeting GPR116. Eur Rev Med Pharmacol Sci. 2019 Jul;23(14):6119-6130. PubMed PMID: 31364112.

Moreno-Salinas AL, Avila-Zozaya M, Ugalde-Silva P, Hernández-Guzmán DA, Missirlis F, Boucard AA. Latrophilins: A neuro-centric view of an evolutionary conserved adhesion G protein-coupled receptor subfamily. Front Neurosci. 2019 Jul 9;13:700. PubMed PMID: 31354411.

Ovando-Zambrano JC, Arias-Montaño JA, Boucard AA. Alternative splicing event modifying ADGRL1/latrophilin-1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways. Ann N Y Acad Sci. 2019 Jul 24. PubMed PMID: 31339586.

Al Hasan M, Roy P, Dolan S, Martin PE, Patterson S, Bartholomew C. Adhesion G-protein coupled receptor 56 is required for 3T3-L1 adipogenesis. J Cell Physiol. 2019 Jul 15. PubMed PMID: 31304602.

Favara DM, Banham AH, Harris AL. ADGRL4/ELTD1 is a highly conserved angiogenesis-associated orphan adhesion GPCR that emerged with the first vertebrates and comprises 3 evolutionary variants. BMC Evol Biol. 2019 Jul 12;19(1):143. PubMed PMID: 31299890.

Burbach JPH, Meijer DH. Latrophilin's social protein network. Front Neurosci. 2019 Jun 26;13:643. Review. PubMed PMID: 31297045.

Vaikari VP, Yang J, Wu S, Alachkar H. CD97 expression is associated with poor overall survival in acute myeloid leukemia. Exp Hematol. 2019 Jul;75:64-73.e4. PubMed PMID: 31260716.

Niaudet C, Petkova M, Jung B, Lu S, Laviña B, Offermanns S, Brakebusch C, Betsholtz C. Adgrf5 contributes to patterning of the endothelial deep layer in retina. Angiogenesis. 2019 Nov;22(4):491-505. PubMed PMID: 31256320.

Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A. The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2019 Jun 6. PubMed PMID: 31168816.

Sita LV, Diniz GB, Horta-Junior JAC, Casatti CA, Bittencourt JC. Nomenclature and comparative morphology of the teneurin/TCAP/ADGRL protein families. Front Neurosci. 2019 May 3;13:425. Review. PubMed PMID: 31130838.

Pater JA, Green J, O'Rielly DD, Griffin A, Squires J, Burt T, Fernandez S, Fernandez B, Houston J, Zhou J, Roslin NM, Young TL. Novel Usher syndrome pathogenic variants identified in cases with hearing and vision loss. BMC Med Genet. 2019 May 2;20(1):68. PubMed PMID: 31046701.

Chen H, Nwe PK, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM, Palm NW. A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology. Cell. 2019 May 16;177(5):1217-1231.e18. PubMed PMID: 31006530.

Cauley ES, Hamed A, Mohamed IN, Elseed M, Martinez S, Yahia A, Abozar F, Abubakr R, Koko M, Elsayed L, Piao X, Salih MA, Manzini MC. Overlap of polymicrogyria, hydrocephalus, and Joubert syndrome in a family with novel truncating mutations in ADGRG1/GPR56 and KIAA0556. Neurogenetics. 2019 May;20(2):91-98. PubMed PMID: 30982090.

Ushkaryov YA, Lelianova V, Vysokov NV. Catching latrophilin with lasso: A universal mechanism for axonal attraction and synapse formation. Front Neurosci. 2019 Mar 22;13:257. Review. PubMed PMID: 30967757.

Kleo K, Dimitrova L, Oker E, Tomaszewski N, Berg E, Taruttis F, Engelmann JC, Schwarzfischer P, Reinders J, Spang R, Gronwald W, Oefner PJ, Hummel M. Identification of ADGRE5 as discriminating MYC target between Burkitt lymphoma and diffuse large B-cell lymphoma. BMC Cancer. 2019 Apr 5;19(1):322. PubMed PMID: 30953469.

Schöneberg T, Prömel S. Latrophilins and teneurins in invertebrates: No love for each other? Front Neurosci. 2019 Mar 12;13:154. Review. PubMed PMID: 30914910.

Ziegler J, Zalles M, Smith N, Saunders D, Lerner M, Fung KM, Patel M, Wren JD, Lupu F, Battiste J, Towner RA. Targeting ELTD1, an angiogenesis marker for glioblastoma (GBM), also affects VEGFR2: molecular-targeted MRI assessment. Am J Nucl Med Mol Imaging. 2019 Feb 15;9(1):93-109. PubMed PMID: 30911439.

Folts CJ, Giera S, Li T, Piao X. Adhesion G protein-coupled receptors as drug targets for neurological diseases. Trends Pharmacol Sci. 2019 Apr;40(4):278-293. Review. PubMed PMID: 30871735.

Langenhan T. Adhesion G protein-coupled receptors-Candidate metabotropic mechanosensors and novel drug targets. Basic Clin Pharmacol Toxicol. 2019 Mar 11. Review. PubMed PMID: 30859707.

Mortimer N, Ganster T, O'Leary A, Popp S, Freudenberg F, Reif A, Soler Artigas M, Ribasés M, Ramos-Quiroga JA, Lesch KP, Rivero O. Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation. Neuropharmacology. 2019 Sep 15;156. PubMed PMID: 30849401.

Yuan P, Liang ZK, Liang H, Zheng LY, Li D, Li J, Zhang J, Tian J, Lai LH, Zhang K, He ZY, Zhang QX, Wang WJ. Expanding the phenotypic and genetic spectrum of Chinese patients with congenital absence of vas deferens bearing CFTR and ADGRG2 alleles. Andrology. 2019 May;7(3):329-340. PubMed PMID: 30811104.

Husić M, Barsyte-Lovejoy D, Lovejoy DA. Teneurin C-terminal associated peptide (TCAP)-1 and latrophilin Interaction in HEK293 cells: Evidence for modulation of intercellular adhesion. Front Endocrinol (Lausanne). 2019 Feb 1;10:22. PubMed PMID: 30774623.

Lindenmaier LB, Parmentier N, Guo C, Tissir F, Wright KM. Dystroglycan is a scaffold for extracellular axon guidance decisions. Elife. 2019 Feb 13;8. PubMed PMID: 30758284.

Wu S, Ou T, Xing N, Lu J, Wan S, Wang C, Zhang X, Yang F, Huang Y, Cai Z. Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer. Nat Commun. 2019 Feb 12;10(1):720. PubMed PMID: 30755618.

Tjong WY, Lin HH. The RGD motif is involved in CD97/ADGRE5-promoted cell adhesion and viability of HT1080 cells. Sci Rep. 2019 Feb 6;9(1):1517. PubMed PMID: 30728423.

Röthe J, Thor D, Winkler J, Knierim AB, Binder C, Huth S, Kraft R, Rothemund S, Schöneberg T, Prömel S. Involvement of the adhesion GPCRs latrophilins in the regulation of insulin release. Cell Rep. 2019 Feb 5;26(6):1573-1584.e5. PubMed PMID: 30726739.

Arcos-Burgos M, Vélez JI, Martinez AF, Ribasés M, Ramos-Quiroga JA, Sánchez-Mora C, Richarte V, Roncero C, Cormand B, Fernández-Castillo N, Casas M, Lopera F, Pineda DA, Palacio JD, Acosta-López JE, Cervantes-Henriquez ML, Sánchez-Rojas MG, Puentes-Rozo PJ, Molina BSG; MTA Cooperative Group, Boden MT, Wallis D, Lidbury B, Newman S, Easteal S, Swanson J, Patel H, Volkow N, Acosta MT, Castellanos FX, de Leon J, Mastronardi CA, Muenke M. ADGRL3 (LPHN3) variants predict substance use disorder. Transl Psychiatry. 2019 Jan 29;9(1):42. PubMed PMID: 30696812.

Scuderi C, Saccuzzo L, Vinci M, Castiglia L, Galesi O, Salemi M, Mattina T, Borgione E, Città S, Romano C, Fichera M. Biallelic intragenic duplication in ADGRB3 (BAI3) gene associated with intellectual disability, cerebellar atrophy, and behavioral disorder. Eur J Hum Genet. 2019 Apr;27(4):594-602. PubMed PMID: 30659260.

Kubo F, Ariestanti DM, Oki S, Fukuzawa T, Demizu R, Sato T, Sabirin RM, Hirose S, Nakamura N. Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells. Respir Res. 2019 Jan 17;20(1):11. PubMed PMID: 30654796.

Kappel DB, Schuch JB, Rovaris DL, da Silva BS, Müller D, Breda V, Teche SP, S Riesgo R, Schüler-Faccini L, Rohde LA, Grevet EH, Bau CHD. ADGRL3 rs6551665 as a common vulnerability factor underlying attention-deficit/hyperactivity disorder and autism spectrum disorder. Neuromolecular Med. 2019 Mar;21(1):60-67. PubMed PMID: 30652248.

Zhu X, Huang G, Jin P. Clinicopathological and prognostic significance of aberrant G protein-couple receptor 110 (GPR110) expression in gastric cancer. Pathol Res Pract. 2019 Mar;215(3):539-545. PubMed PMID: 30638950.

Park GB, Kim D. MicroRNA-503-5p inhibits the CD97-mediated JAK2/STAT3 pathway in metastatic or Paclitaxel-resistant ovarian cancer cells. Neoplasia. 2019 Feb;21(2):206-215. PubMed PMID: 30622051.

Tan A, Ke S, Chen Y, Chen L, Lu X, Ding F, Yang L, Tang Y, Yu Y. Expression patterns of C1ql4 and its cell-adhesion GPCR Bai3 in the murine testis and functional roles in steroidogenesis. FASEB J. 2019 Apr;33(4):4893-4906. PubMed PMID: 30608882.

Weng Z, Situ C, Lin L, Wu Z, Zhu J, Zhang R. Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. Nat Commun. 2019 Jan 3;10(1):51. PubMed PMID: 30604775.

Hassan A, Bagu ET, Levesque M, Patten SA, Benhadjeba S, Edjekouane L, Villemure I, Tremblay A, Moldovan F. The 17β-estradiol induced upregulation of the adhesion G-protein coupled receptor (ADGRG7) is modulated by ESRα and SP1 complex. Biol Open. 2019 Jan 14;8(1). PubMed PMID: 30598481.

Hosseini M, Fattahi Z, Abedini SS, Hu H, Ropers HH, Kalscheuer VM, Najmabadi H, Kahrizi K. GPR126: A novel candidate gene implicated in autosomal recessive intellectual disability. Am J Med Genet A. 2019 Jan;179(1):13-19. PubMed PMID: 30549416.

Chong ZS, Ohnishi S, Yusa K, Wright GJ. Pooled extracellular receptor-ligand interaction screening using CRISPR activation. Genome Biol. 2018 Nov 26;19(1):205. PubMed PMID: 30477585.

Zhao Z, Reimann S, Wang S, Wang Y, Zuberbier T. Ordinary vibratory angioedema is not generally associated with ADGRE2 mutation. J Allergy Clin Immunol. 2019 Mar;143(3):1246-1248.e4. PubMed PMID: 30445064.

Huang X, Zhang Q, Gu X, Hou Y, Wang M, Chen X, Wu J. LPHN3 gene variations and susceptibility to ADHD in Chinese Han population: a two-stage case-control association study and gene-environment interactions. Eur Child Adolesc Psychiatry. 2019 Jun;28(6):861-873. PubMed PMID: 30406846.

Garinet S, Pignot G, Vacher S, Le Goux C, Schnitzler A, Chemlali W, Sirab N, Barry Delongchamps N, Zerbib M, Sibony M, Allory Y, Damotte D, Bieche I. High prevalence of a hotspot of noncoding somatic Mutations in intron 6 of GPR126 in bladder cancer. Mol Cancer Res. 2019 Feb;17(2):469-475. PubMed PMID: 30401719.

Dalla Vecchia E, Mortimer N, Palladino VS, Kittel-Schneider S, Lesch KP, Reif A, Schenck A, Norton WHJ. Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: lessons from CNTNAP2, ADGRL3, and PARK2. Psychiatr Genet. 2019 Feb;29(1):1-17. Review. PubMed PMID: 30376466.


Hsiao CC, Chu TY, Wu CJ, van den Biggelaar M, Pabst C, Hébert J, Kuijpers TW, Scicluna BP, I KY, Chen TC, Liebscher I, Hamann J, Lin HH. The adhesion G protein-coupled receptor GPR97/ADGRG3 Is expressed in human granulocytes and triggers antimicrobial effector functions. Front Immunol. 2018 Dec 3;9:2830. PubMed PMID: 30559745.

Moon SY, Shin SA, Oh YS, Park HH, Lee CS. Understanding the role of the BAI subfamily of adhesion G protein-coupled receptors (GPCRs) in pathological and physiological conditions. Genes (Basel). 2018 Nov 30;9(12). Review. PubMed PMID: 30513696.

Öncü-Öner T, Ünalp A, Porsuk-Doru İ, Ağılkaya S, Güleryüz H, Saraç A, Ergüner B, Yüksel B, Hız-Kurul S, Cingöz S. GPR56 homozygous nonsense mutation p.R271* associated with phenotypic variability in bilateral frontoparietal polymicrogyria. Turk J Pediatr. 2018;60(3):229-237. PubMed PMID: 30511534.

Wang Z, Li Y, Zhou F, Piao Z, Hao J. β-elemene enhances anticancer bone neoplasms efficacy of paclitaxel through regulation of GPR124 in bone neoplasms cells. Oncol Lett. 2018 Aug;16(2):2143-2150. PubMed PMID: 30008912.

Chong ZS, Ohnishi S, Yusa K, Wright GJ. Pooled extracellular receptor-ligand interaction screening using CRISPR activation. Genome Biol. 2018 Nov 26;19(1):205. PubMed PMID: 30477585.

Vysokov NV, Silva JP, Lelianova VG, Suckling J, Cassidy J, Blackburn JK, Yankova N, Djamgoz MB, Kozlov SV, Tonevitsky AG, Ushkaryov YA. Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones. Elife. 2018 Nov 20;7. PubMed PMID: 30457553.

Nazarko O, Kibrom A, Winkler J, Leon K, Stoveken H, Salzman G, Merdas K, Lu Y, Narkhede P, Tall G, Prömel S, Araç D. A Comprehensive mutagenesis screen of the adhesion GPCR latrophilin-1/ADGRL1. iScience. 2018 May 25;3:264-278. PubMed PMID: 30428326.

Vezain M, Lecuyer M, Rubio M, Dupé V, Ratié L, David V, Pasquier L, Odent S, Coutant S, Tournier I, Trestard L, Adle-Biassette H, Vivien D, Frébourg T, Gonzalez BJ, Laquerrière A, Saugier-Veber P. A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis. Acta Neuropathol Commun. 2018 Oct 19;6(1):109. PubMed PMID: 30340542.

Hamoud N, Tran V, Aimi T, Kakegawa W, Lahaie S, Thibault MP, Pelletier A, Wong GW, Kim IS, Kania A, Yuzaki M, Bouvier M, Côté JF. Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and stabilin-2 controls myoblast fusion. Nat Commun. 2018 Oct 26;9(1):4470. PubMed PMID: 30367035.

Lagou V, Garcia-Perez JE, Smets I, Van Horebeek L, Vandebergh M, Chen L, Mallants K, Prezzemolo T, Hilven K, Humblet-Baron S, Moisse M, Van Damme P, Boeckxstaens G, Bowness P, Dubois B, Dooley J, Liston A, Goris A. Genetic architecture of adaptive immune system identifies key immune regulators. Cell Rep. 2018 Oct 16;25(3):798-810.e6. PubMed PMID: 30332657.

Waddell LA, Lefevre L, Bush SJ, Raper A, Young R, Lisowski ZM, McCulloch MEB, Muriuki C, Sauter KA, Clark EL, Irvine KM, Pridans C, Hope JC, Hume DA. ADGRE1 (EMR1, F4/80) is a rapidly-evolving Gene expressed in mammalian monocyte-macrophages. Front Immunol. 2018 Oct 1;9:2246. PubMed PMID: 30327653.

Vallon M, Yuki K, Nguyen TD, Chang J, Yuan J, Siepe D, Miao Y, Essler M, Noda M, Garcia KC, Kuo CJ. A RECK-WNT7 receptor-ligand interaction enables isoform-specific regulation of Wnt bioavailability. Cell Rep. 2018 Oct 9;25(2):339-349.e9. PubMed PMID: 30304675.

Gupta R, Nguyen DC, Schaid MD, Lei X, Balamurugan AN, Wong GW, Kim JA, Koltes JE, Kimple ME, Bhatnagar S. Complement 1q like-3 protein inhibits insulin secretion from pancreatic β-cells via the cell adhesion G protein-coupled receptor BAI3. J Biol Chem. 2018 Nov 23;293(47):18086-18098. PubMed PMID: 30228187.

Hilbig D, Sittig D, Hoffmann F, Rothemund S, Warmt E, Quaas M, Stürmer J, Seiler L, Liebscher I, Hoang NA, Käs JA, Banks L, Aust G. Mechano-dependent phosphorylation of the PDZ-binding motif of CD97/ADGRE5 modulates cellular detachment. Cell Rep. 2018 Aug 21;24(8):1986-1995. PubMed PMID: 30134161.

Tu YK, Duman JG, Tolias KF. The adhesion-GPCR BAI1 promotes excitatory synaptogenesis by coordinating bidirectional trans-synaptic signaling. J Neurosci. 2018 Sep 26;38(39):8388-8406. PubMed PMID: 30120207.

Blanco-Redondo B, Langenhan T. Parallel genomic engineering of two Drosophila genes using orthogonal attB/attP sites. G3 (Bethesda). 2018 Aug 30;8(9):3109-3118. PubMed PMID: 30065043.

Kan A, Le Y, Zhang YF, Duan FT, Zhong XP, Lu LH, Ling YH, Guo RP. ELTD1 function in hepatocellular carcinoma is carcinoma-associated
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Eubelen M, Bostaille N, Cabochette P, Gauquier A, Tebabi P, Dumitru AC, Koehler M, Gut P, Alsteens D, Stainier DYR, Garcia-Pino A, Vanhollebeke B. A molecular mechanism for Wnt ligand-specific signaling. Science. 2018 Aug 17;361(6403). PubMed PMID: 30026314.

Wang Z, Li Y, Zhou F, Piao Z, Hao J. β-elemene enhances anticancer bone neoplasms efficacy of paclitaxel through regulation of GPR124 in bone neoplasms cells. Oncol Lett. 2018 Aug;16(2):2143-2150. PubMed PMID: 30008912.

Choi JS, Bae WY, Nam S, Jeong JW. New targets for Parkinson's disease: Adhesion G protein-coupled receptor B1 is downregulated by AMP-activated protein kinase activation. OMICS. 2018 Jul;22(7):493-501. PubMed PMID: 30004846.

Heinzelmann K, Lehmann M, Gerckens M, Noskovičová N, Frankenberger M, Lindner M, Hatz R, Behr J, Hilgendorff A, Königshoff M, Eickelberg O. Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L682-L696. PubMed PMID: 29952218.

Sakhnevych SS, Yasinska IM, Bratt AM, Benlaouer O, Gonçalves Silva I, Hussain R, Siligardi G, Fiedler W, Wellbrock J, Gibbs BF, Ushkaryov YA, Sumbayev VV. Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression. Cell Mol Immunol. 2018 Nov;15(11):994-997. PubMed PMID: 29907881.

Lange M, Froc C, Grunwald H, Norton WHJ, Bally-Cuif L. Pharmacological analysis of zebrafish lphn3.1 morphant larvae suggests that saturated dopaminergic signaling could underlie the ADHD-like locomotor hyperactivity. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt A):181-189. PubMed PMID: 29496512.

Kocibalova Z, Guzyova M, Imrichova D, Sulova Z, Breier A. Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1. Gen Physiol Biophys. 2018 May;37(3):353-357. PubMed PMID: 29938681.

BAI1 stabilizes p53 to suppress medulloblastoma tumorigenesis. Cancer Discov. 2018 Aug;8(8):912. PubMed PMID: 29907588.

Zhu D, Osuka S, Zhang Z, Reichert ZR, Yang L, Kanemura Y, Jiang Y, You S, Zhang H, Devi NS, Bhattacharya D, Takano S, Gillespie GY, Macdonald T, Tan C, Nishikawa R, Nelson WG, Olson JJ, Van Meir EG. BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5. PubMed PMID: 29894688.

Wei C, Yang L, Cheng J, Imani S, Fu S, Lv H, Li Y, Chen R, Leung EL, Fu J. A novel homozygous variant of GPR98 causes usher syndrome type IIC in a consanguineous Chinese family by next generation sequencing. BMC Med Genet. 2018 Jun 11;19(1):99. PubMed PMID: 29890953.

Hilbig D, Dietrich N, Wandel E, Gonsior S, Sittig D, Hamann J, Aust G. The interaction of CD97/ADGRE5 with β-Catenin in adherens junctions is lost during colorectal carcinogenesis. Front Oncol. 2018 May 25;8:182. PubMed PMID: 29888202.

Wang J, Wang X, Chen X, Lu S, Kuang Y, Fei J, Wang Z. Gpr97/Adgrg3 ameliorates experimental autoimmune encephalomyelitis by regulating cytokine expression. Acta Biochim Biophys Sin (Shanghai). 2018 Jul 1;50(7):666-675. PubMed PMID: 29860267.

Olaniru OE, Pingitore A, Giera S, Piao X, Castañera González R, Jones PM, Persaud SJ. The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function. Cell Mol Life Sci. 2018 Nov;75(21):4007-4019. PubMed PMID: 29855662.

Giera S, Luo R, Ying Y, Ackerman SD, Jeong SJ, Stoveken HM, Folts CJ, Welsh CA, Tall GG, Stevens B, Monk KR, Piao X. Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Elife. 2018 May 29;7. PubMed PMID: 29809138.

Gao S, Xiong W, Wei L, Liu J, Liu X, Xie J, Song X, Bi J, Li B. Transcriptome profiling analysis reveals the role of latrophilin in controlling development, reproduction and insecticide susceptibility in Tribolium castaneum. Genetica. 2018 Jun;146(3):287-302. PubMed PMID: 29797154.

Sawal HA, Harripaul R, Mikhailov A, Vleuten K, Naeem F, Nasr T, Hassan MJ, Vincent JB, Ayub M, Rafiq MA. Three mutations in the bilateral frontoparietal polymicrogyria gene GPR56 in Pakistani intellectual disability families. J Pediatr Genet. 2018 Jun;7(2):60-66. PubMed PMID: 29707406.

Yin Y, Xu X, Tang J, Zhang W, Zhangyuan G, Ji J, Deng L, Lu S, Zhuo H, Sun B. CD97 promotes tumor Aggressiveness through the traditional G protein-coupled receptor-mediated signaling in hepatocellular carcinoma. Hepatology. 2018 Nov;68(5):1865-1878. PubMed PMID: 29704239.

Li J, Shalev-Benami M, Sando R, Jiang X, Kibrom A, Wang J, Leon K, Katanski C, Nazarko O, Lu YC, Südhof TC, Skiniotis G, Araç D. Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse. Cell. 2018 Apr 19;173(3):735-748.e15. PubMed PMID: 29677516.

Ward Y, Lake R, Faraji F, Sperger J, Martin P, Gilliard C, Ku KP, Rodems T, Niles D, Tillman H, Yin J, Hunter K, Sowalsky AG, Lang J, Kelly K. Platelets promote metastasis via binding tumor CD97 leading to bidirectional signaling that coordinates transendothelial migration. Cell Rep. 2018 Apr 17;23(3):808-822. PubMed PMID: 29669286.

Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, Peng R, Finnell RH, Zhang T, Wang H. Genetic analysis of Wnt/PCP genes in neural tube defects. BMC Med Genomics. 2018 Apr 4;11(1):38. PubMed PMID: 29618362.

Bhat RR, Yadav P, Sahay D, Bhargava DK, Creighton CJ, Yazdanfard S, Al-Rawi A, Yadav V, Qin L, Nanda S, Sethunath V, Fu X, De Angelis C, Narkar VA, Osborne CK, Schiff R, Trivedi MV. GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer. Breast Cancer Res Treat. 2018 Jul;170(2):279-292. PubMed PMID: 29574636.

Huang YS, Chiang NY, Chang GW, Lin HH. Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation. Sci Rep. 2018 Mar 14;8(1):4532. PubMed PMID: 29540735.

Scholz N. Cancer cell mechanics: Adhesion G protein-coupled receptors in action? Front Oncol. 2018 Mar 13;8:59. PubMed PMID: 29594040.

Fang W, Wang Z, Li Q, Wang X, Zhang Y, Sun Y, Tang W, Ma C, Sun J, Li N, Yi F. Gpr97 exacerbates AKI by mediating Sema3A signaling. J Am Soc Nephrol. 2018 May;29(5):1475-1489. PubMed PMID: 29531097.

Lange M, Froc C, Grunwald H, Norton WHJ, Bally-Cuif L. Pharmacological analysis of zebrafish lphn3.1 morphant larvae suggests that saturated dopaminergic signaling could underlie the ADHD-like locomotor hyperactivity. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 26;84(Pt A):181-189. PubMed PMID: 29496512.

Jiang L, Zhang X, Xiang C, Geradts J, Wei Q, Liang Y, Huang H, Xu JF. Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer. Histol Histopathol. 2018 Feb 28:11979. doi: 10.14670/HH-11-979. [Epub ahead of print] PubMed PMID: 29489009.

Stoveken HM, Larsen SD, Smrcka AV, Tall GG. Gedunin- and Khivorin-derivatives are small molecule partial agonists for adhesion G protein coupled receptors GPR56/ADGRG1 and GPR114/ADGRG5. Mol Pharmacol. 2018 May;93(5):477-488. PubMed PMID: 29476042.

Cazorla-Vázquez S, Engel FB. Adhesion GPCRs in kidney development and disease. Front Cell Dev Biol. 2018 Feb 6;6:9. Review. PubMed PMID: 29468160.

Seigfried FA, Dietmann P, Kühl M, Kühl SJ. Expression of the adhesion G protein-coupled receptor A2 (adgra2) during Xenopus laevis development. Gene Expr Patterns. 2018 Jun;28:54-61. PubMed PMID: 29462671.

Millar MW, Corson N, Xu L. The adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits cell-extracellular matrix signaling to prevent metastatic melanoma growth. Front Oncol. 2018 Feb 1;8:8. PubMed PMID: 29450192.

Gong DM, Zhang YL, Chen DY, Hong LJ, Han F, Liu QB, Jiang JJ, Lu YM. Endothelial GPR124 Exaggerates the Pathogenesis of Atherosclerosis by Activating Inflammation. Cell Physiol Biochem. 2018;45(2):547-557. Epub 2018 Jan 25. PubMed PMID: 29402834.

Liu M, Zhang J, Liu C. Clinical efficacy of recombinant human latrophilin 3 antibody in the treatment of pediatric asthma. Exp Ther Med. 2018 Jan;15(1):539-547. PubMed PMID: 29375702.

Boucherie C, Boutin C, Jossin Y, Schakman O, Goffinet AM, Ris L, Gailly P, Tissir F. Neural progenitor fate decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice. Mol Psychiatry. 2018 Mar;23(3):723-734. PubMed PMID: 29257130.

Tokoro Y, Yamada Y, Takayanagi SI, Hagiwara T. 57R2A, a newly established monoclonal antibody against mouse GPR56, marks long-term repopulating hematopoietic stem cells. Exp Hematol. 2018 Mar;59:51-59.e1. PubMed PMID: 29225194.


Einarsdottir E, Grauers A, Wang J, Jiao H, Escher SA, Danielsson A, Simony A, Andersen M, Christensen SB, Åkesson K, Kou I, Khanshour AM, Ohlin A, Wise C, Ikegawa S, Kere J, Gerdhem P. CELSR2 is a candidate susceptibility gene in idiopathic scoliosis. PLoS One. 2017 Dec 14;12(12):e0189591. PubMed PMID: 29240829.

Moreno M, Pedrosa L, Paré L, Pineda E, Bejarano L, Martínez J, Balasubramaniyan V, Ezhilarasan R, Kallarackal N, Kim SH, Wang J, Audia A, Conroy S, Marin M, Ribalta T, Pujol T, Herreros A, Tortosa A, Mira H, Alonso MM, Gómez-Manzano C, Graus F, Sulman EP, Piao X, Nakano I, Prat A, Bhat KP, de la Iglesia N. GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma. Cell Rep. 2017 Nov 21;21(8):2183-2197. PubMed PMID: 29166609.

Tian Y, Babor M, Lane J, Schulten V, Patil VS, Seumois G, Rosales SL, Fu Z, Picarda G, Burel J, Zapardiel-Gonzalo J, Tennekoon RN, De Silva AD, Premawansa S, Premawansa G, Wijewickrama A, Greenbaum JA, Vijayanand P, Weiskopf D, Sette A, Peters B. Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA. Nat Commun. 2017 Nov 13;8(1):1473. PubMed PMID: 29133794.

Tian H, Chen Y, Zhao JG, Liu DR, Gong WH, Chen L, Wu YL, Wang JA. Effects of targeted CD97 immune epitopes small interference RNA on cellular biological behaviors in MDA-MB231 malignant breast cancer cell line. Am J Transl Res. 2017 Oct 15;9(10):4640-4651. PubMed PMID: 29118924.

Feliciano A, Garcia-Mayea Y, Jubierre L, Mir C, Hummel M, Castellvi J, Hernández-Losa J, Paciucci R, Sansano I, Sun Y, Cajal SRY, Kondon H, Soriano A, Segura M, Lyakhovich A, LLeonart ME. miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer. Cell Death Dis. 2017 Oct 26;8(10):e3141. PubMed PMID: 29072692.

Eichstaedt CA, Pagani L, Antao T, Inchley CE, Cardona A, Mörseburg A, Clemente FJ, Sluckin TJ, Metspalu E, Mitt M, Mägi R, Hudjashov G, Metspalu M, Mormina M, Jacobs GS, Kivisild T. Evidence of Early-stage selection on EPAS1 and GPR126 genes in Andean high altitude populations. Sci Rep. 2017 Oct 12;7(1):13042. PubMed PMID: 29026132.

Guo T, Repetto GM, McDonald McGinn DM, Chung JH, Nomaru H, Campbell CL, Blonska A, Bassett AS, Chow EWC, Mlynarski EE, Swillen A, Vermeesch J, Devriendt K, Gothelf D, Carmel M, Michaelovsky E, Schneider M, Eliez S, Antonarakis SE, Coleman K, Tomita-Mitchell A, Mitchell ME, Digilio MC, Dallapiccola B, Marino B, Philip N, Busa T, Kushan-Wells L, Bearden CE, Piotrowicz M, Hawuła W, Roberts AE, Tassone F, Simon TJ, van Duin EDA, van Amelsvoort TA, Kates WR, Zackai E, Johnston HR, Cutler DJ, Agopian AJ, Goldmuntz E, Mitchell LE, Wang T, Emanuel BS, Morrow BE; International 22q11.2 Consortium/Brain and Behavior Consortium*. Genome-wide association study to find modifiers for tetralogy of Fallot in the 22q11.2 deletion syndrome identifies variants in the GPR98 locus on 5q14.3. Circ Cardiovasc Genet. 2017 Oct;10(5). pii: e001690. PubMed PMID: 29025761.

Anderson GR, Maxeiner S, Sando R, Tsetsenis T, Malenka RC, Südhof TC. Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly. J Cell Biol. 2017 Nov 6;216(11):3831-3846. PubMed PMID: 28972101.

Thomas M, Snead D, Mitchell D. An investigation into the potential role of brain angiogenesis inhibitor protein 3 (BAI3) in the tumorigenesis of small-cell carcinoma: a review of the surrounding literature. J Recept Signal Transduct Res. 2017 Aug;37(4):325-334. PubMed PMID: 28537194.

Dos Anjos Cassado A. F4/80 as a major macrophage marker: The case of the peritoneum and spleen. Results Probl Cell Differ. 2017;62:161-179. PubMed PMID: 28455709.

Burzava ALS, Jasieniak M, Cockshell MP, Bonder CS, Harding FJ, Griesser HJ, Voelcker NH. Affinity binding of EMR2 expressing cells by surface-grafted chondroitin sulfate B. Biomacromolecules. 2017 Jun 12;18(6):1697-1704. PubMed PMID: 28437084.

Kishore A, Hall RA. Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling. J Biol Chem. 2017 Jun 9;292(23):9711-9720. PubMed PMID: 28424266.

I KY, Huang YS, Hu CH, Tseng WY, Cheng CH, Stacey M, Gordon S, Chang GW, Lin HH. Activation of adhesion GPCR EMR2/ADGRE2 induces macrophage differentiation and inflammatory responses via Gα(16)/Akt/MAPK/NF-κB signaling pathways. Front Immunol. 2017 Apr 3;8:373. PubMed PMID: 28421075.

Jin G, Sakatani K, Wang H, Jin Y, Dubeykovskiy A, Worthley DL, Tailor Y, Wang TC. The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis. Oncotarget. 2017 Jun 20;8(25):40606-40619. PubMed PMID: 28380450.

Zhao W, Wang Z, Sun Z, Wang S, Wu M, Zheng L. Lentivirus‑mediated overexpression of CD97/ADGRE5 reverses dysregulated high glucose‑induced endothelial cell migration. Mol Med Rep. 2017 May;15(5):3048-3054. PubMed PMID: 28358422.

Meng ZW, Liu MC, Hong HJ, Du Q, Chen YL. Expression and prognostic value of soluble CD97 and its ligand CD55 in intrahepatic cholangiocarcinoma. Tumour Biol. 2017 Mar;39(3):1010428317694319. PubMed PMID: 28345461.

Fernandez C, Iyer M, Low I. Gpr126 Is Critical for Schwann Cell Function during peripheral nerve regeneration. J Neurosci. 2017 Mar 22;37(12):3106-3108. PubMed PMID: 28330980.

Chang J, Mancuso MR, Maier C, Liang X, Yuki K, Yang L, Kwong JW, Wang J, Rao V, Vallon M, Kosinski C, Zhang JJ, Mah AT, Xu L, Li L, Gholamin S, Reyes TF, Li R, Kuhnert F, Han X, Yuan J, Chiou SH, Brettman AD, Daly L, Corney DC, Cheshier SH, Shortliffe LD, Wu X, Snyder M, Chan P, Giffard RG, Chang HY, Andreasson K, Kuo CJ. Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nat Med. 2017 Apr;23(4):450-460. PubMed PMID: 28288111.

Mathema VB, Na-Bangchang K. Regulatory roles of brain-specific angiogenesis inhibitor 1(BAI1) protein in inflammation, tumorigenesis and phagocytosis: A brief review. Crit Rev Oncol Hematol. 2017 Mar;111:81-86. Review. PubMed PMID: 28259299.

Vandervore L, Stouffs K, Tanyalçin I, Vanderhasselt T, Roelens F, Holder-Espinasse M, Jørgensen A, Pepin MG, Petit F, Khau Van Kien P, Bahi-Buisson N, Lissens W, Gheldof A, Byers PH, Jansen AC. Bi-allelic variants in COL3A1 encoding the ligand to GPR56 are associated with cobblestone-like cortical malformation, white matter changes and cerebellar cysts. J Med Genet. 2017 Jun;54(6):432-440. PubMed PMID: 28258187.

Kang JH, Sim JS, Zheng T, Yim M. F4/80 inhibits osteoclast differentiation via downregulation of nuclear factor of activated T cells, cytoplasmic 1. Arch Pharm Res. 2017 Apr;40(4):492-499. PubMed PMID: 28211012.

Qin X, Xu L, Xia C, Zhu W, Sun W, Liu Z, Qiu Y, Zhu Z. Genetic variant of GPR126 gene is functionally associated with adolescent idiopathic scoliosis in Chinese population. Spine (Phila Pa 1976). 2017 Oct 1;42(19):E1098-E1103. PubMed PMID: 28198779.

Demberg LM, Winkler J, Wilde C, Simon KU, Schön J, Rothemund S, Schöneberg T, Prömel S, Liebscher I. Activation of adhesion G protein-coupled receptors: agonist specificity of Stachel sequence-derived peptides. J Biol Chem. 2017 Mar 17;292(11):4383-4394. PubMed PMID: 28154189.

Mogha A, D’Rozario M, Monk KR. G protein-coupled receptors in myelinating glia. Trends Pharmacol Sci. 2017 Mar;38(3):316. PubMed PMID: 28118935.

Thakar S, Wang L, Yu T, Ye M, Onishi K, Scott J, Qi J, Fernandes C, Han X, Yates JR 3rd, Berg DK, Zou Y. Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E610-E618. PubMed PMID: 28057866.

Vilboux T, Malicdan MC, Roney JC, Cullinane AR, Stephen J, Yildirimli D, Bryant J, Fischer R, Vemulapalli M, Mullikin JC; NISC Comparative Sequencing Program, Steinbach PJ, Gahl WA, Gunay-Aygun M. CELSR2, encoding a planar cell polarity protein, is a putative gene in Joubert syndrome with cortical heterotopia, microophthalmia, and growth hormone deficiency. Am J Med Genet A. 2017 Mar;173(3):661-666. PubMed PMID: 28052552.

Bostaille N, Gauquier A, Stainier DY, Raible DW, Vanhollebeke B. Defective adgra2 (gpr124) splicing and function in zebrafish ouchless mutants. Development. 2017 Jan 1;144(1):8-11. PubMed PMID: 27979884.

Mehta P, Piao X. Adhesion G-protein coupled receptors and extracellular matrix proteins: Roles in myelination and glial cell development. Dev Dyn. 2017 Apr;246(4):275-284. Review. PubMed PMID: 27859941.

Bolyard C, Meisen WH, Banasavadi-Siddegowda Y, Hardcastle J, Yoo JY, Wohleb ES, Wojton J, Yu JG, Dubin S, Khosla M, Xu B, Smith J, Alvarez-Breckenridge C, Pow-Anpongkul P, Pichiorri F, Zhang J, Old M, Zhu D, Van Meir EG, Godbout JP, Caligiuri MA, Yu J, Kaur B. BAI1 orchestrates macrophage inflammatory response to HSV infection-implications for oncolytic viral therapy. Clin Cancer Res. 2017 Apr 1;23(7):1809-1819. PubMed PMID: 27852701.

Hardin M, Cho MH, Sharma SS, Glass K, Castaldi PJ, McDonald ML, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O’Connor GT, Dupuis J, Hokanson J, Crapo J, Beaty TH, Laird N, Silverman EK, DeMeo DL; COPDGene and ECLIPSE Investigators. Sex-based genetic association study identifies CELSR1 as a possible COPD risk locus among women. Am J Respir Cell Mol Biol. 2017 Mar;56(3):332-341. PubMed PMID: 27854507.

Chiang NY, Peng YM, Juang HH, Chen TC, Pan HL, Chang GW, Lin HH. GPR56/ADGRG1 activation promotes melanoma cell migration via NTF dissociation and CTF-mediated Gα(12/13)/RhoA signaling. J Invest Dermatol. 2017 Mar;137(3):727-736. PubMed PMID: 27818281.

Balenga N, Azimzadeh P, Hogue JA, Staats PN, Shi Y, Koh J, Dressman H, Olson JA. Orphan adhesion GPCR GPR64/ADGRG2 is overexpressed in parathyroid tumors and attenuates calcium-sensing receptor-mediated signaling. J Bone Miner Res. 2017 Mar;32(3):654-666. PubMed PMID: 27760455.

Qiao X, Liu Y, Li P, Chen Z, Li H, Yang X, Finnell RH, Yang Z, Zhang T, Qiao B, Zheng Y, Wang H. Genetic analysis of rare coding mutations in CELSR1-3 in Chinese congenital heart and neural tube defects. Clin Sci (Lond). 2016 Oct 18. pii: CS20160686. PubMed PMID: 27756857.

Yang LY, Liu XF, Yang Y, Yang LL, Liu KW, Tang YB, Zhang M, Tan MJ, Cheng SM, Xu YC, Yang HY, Liu ZJ, Song GJ, Huang W. Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities. Acta Pharmacol Sin. 2017 Jan;38(1):56-68. PubMed PMID: 27641734.

Ziegler J, Pody R, Coutinho de Souza P, Evans B, Saunders D, Smith N, Mallory S, Njoku C, Dong Y, Chen H, Dong J, Lerner M, Mian O, Tummala S, Battiste J, Fung KM, Wren JD, Towner RA. ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models. Neuro Oncol. 2017 Feb 1;19(2):175-185. PubMed PMID: 27416955.

Serban F, Daianu O, Tataranu LG, Artene SA, Emami G, Georgescu AM, Alexandru O, Purcaru SO, Tache DE, Danciulescu MM, Sfredel V, Dricu A. Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA induced cell death in glioblastoma. J Immunoassay Immunochem. 2017;38(1):21-33. PubMed PMID: 27379831.

Faiz A, Donovan C, Nieuwenhuis MA, van den Berge M, Postma DS, Yao S, Park CY, Hirsch R, Fredberg JJ, Tjin G, Halayko AJ, Rempel KL, Ward JP, Lee T, Bossé Y, Nickle DC, Obeidat M, Vonk JM, Black JL, Oliver BG, Krishnan R, McParland B, Bourke JE, Burgess JK. Latrophilin receptors: novel bronchodilator targets in asthma. Thorax. 2017 Jan;72(1):74-82. PubMed PMID: 27325752.


Zuko A, Oguro-Ando A, Post H, Taggenbrock RL, van Dijk RE, Altelaar AF, Heck AJ, Petrenko AG, van der Zwaag B, Shimoda Y, Pasterkamp RJ, Burbach JP. Association of cell adhesion molecules contactin-6 and latrophilin-1 regulates neuronal apoptosis. Front Mol Neurosci. 2016 Dec 15;9:143. PubMed PMID: 28018171.

Bostaille N, Gauquier A, Twyffels L, Vanhollebeke B. Molecular insights into Adgra2/Gpr124 and Reck intracellular trafficking. Biol Open. 2016 Dec 15;5(12):1874-1881. PubMed PMID: 27979830.

Mogha A, Harty BL, Carlin D, Joseph J, Sanchez NE, Suter U, Piao X, Cavalli V, Monk KR. Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair. J Neurosci. 2016 Dec 7;36(49):12351-12367. PubMed PMID: 27927955.

Huang CH, Jeng WJ, Ho YP, Teng W, Hsieh YC, Chen WT, Chen YC, Lin HH, Sheen IS, Lin CY. Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients. Sci Rep. 2016 Dec 1;6:38250. PubMed PMID: 27905560.

Liu Z, Huang Z, Yang W, Li Z, Xing S, Li H, Hu B, Li P. Expression of orphan GPR56 correlates with tumor progression in human epithelial ovarian cancer. Neoplasma. 2016 Nov 24;64(1). PubMed PMID: 27881002.

Aust G, Zhu D, Van Meir EG, Xu L. Adhesion GPCRs in tumorigenesis. Handb Exp Pharmacol. 2016;234:369-396. PubMed PMID: 27832497.

Musa G, Engel FB, Niaudet C. Heart development, angiogenesis, and blood-brain barrier function is modulated by adhesion GPCRs. Handb Exp Pharmacol. 2016;234:351-368. PubMed PMID: 27832496.

Hamann J, Hsiao CC, Lee CS, Ravichandran KS, Lin HH. Adhesion GPCRs as modulators of immune cell function. Handb Exp Pharmacol. 2016;234:329-350. PubMed PMID: 27832495.

Ludwig MG, Seuwen K, Bridges JP. Adhesion GPCR function in pulmonary development and disease. Handb Exp Pharmacol. 2016;234:309-327. PubMed PMID: 27832494.

White JP. Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs. Handb Exp Pharmacol. 2016;234:299-308. PubMed PMID: 27832493.

Sigoillot SM, Monk KR, Piao X, Selimi F, Harty BL. Adhesion GPCRs as novel actors in neural and glial cell functions: From synaptogenesis to myelination. Handb Exp Pharmacol. 2016;234:275-298. PubMed PMID: 27832492.

Strutt D, Schnabel R, Fiedler F, Prömel S. Adhesion GPCRs govern polarity of epithelia and cell migration. Handb Exp Pharmacol. 2016;234:249-274. PubMed PMID: 27832491.

Scholz N, Monk KR, Kittel RJ, Langenhan T. Adhesion GPCRs as a putative class of metabotropic mechanosensors. Handb Exp Pharmacol. 2016;234:221-247. PubMed PMID: 27832490.

Kovacs P, Schöneberg T. The relevance of genomic signatures at adhesion GPCR loci in humans. Handb Exp Pharmacol. 2016;234:179-217. PubMed PMID: 27832489.

Knapp B, Wolfrum U. Adhesion GPCR-related protein networks. Handb Exp Pharmacol. 2016;234:147-178. PubMed PMID: 27832488.

Kishore A, Hall RA. Versatile signaling activity of adhesion GPCRs. Handb Exp Pharmacol. 2016;234:127-146. PubMed PMID: 27832487.

Liebscher I, Schöneberg T. Tethered Agonism: A common activation mechanism of adhesion GPCRs. Handb Exp Pharmacol. 2016;234:111-125. PubMed PMID: 27832486.

Nieberler M, Kittel RJ, Petrenko AG, Lin HH, Langenhan T. Control of adhesion GPCR function through proteolytic processing. Handb Exp Pharmacol. 2016;234:83-109. PubMed PMID: 27832485.

Araç D, Sträter N, Seiradake E. Understanding the structural basis of adhesion GPCR functions. Handb Exp Pharmacol. 2016;234:67-82. PubMed PMID: 27832484.

de Graaf C, Nijmeijer S, Wolf S, Ernst OP. 7TM domain structure of adhesion GPCRs. Handb Exp Pharmacol. 2016;234:43-66. PubMed PMID: 27832483.

Krishnan A, Nijmeijer S, de Graaf C, Schiöth HB. Classification, nomenclature, and structural aspects of adhesion GPCRs. Handb Exp Pharmacol. 2016;234:15-41. PubMed PMID: 27832482.

Hamann J, Petrenko AG. Introduction: History of the adhesion GPCR field. Handb Exp Pharmacol. 2016;234:1-11. PubMed PMID: 27832481.

Martinez AF, Abe Y, Hong S, Molyneux K, Yarnell D, Löhr H, Driever W, Acosta MT, Arcos-Burgos M, Muenke M. An ultraconserved brain-specific enhancer within ADGRL3 (LPHN3) underpins attention-deficit/hyperactivity disorder susceptibility. Biol Psychiatry. 2016 Dec 15;80(12):943-954. PubMed PMID: 27692237.

Brzóska HŁ, d’Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA. Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning. Kidney Int. 2016 Dec;90(6):1274-1284. PMID: 27597235.

Bayin NS, Frenster JD, Kane JR, Rubenstein J, Modrek AS, Baitalmal R, Dolgalev I, Rudzenski K, Scarabottolo L, Crespi D, Redaelli L, Snuderl M, Golfinos JG, Doyle W, Pacione D, Parker EC, Chi AS, Heguy A, MacNeil DJ, Shohdy N, Zagzag D, Placantonakis DG. GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth. Oncogenesis. 2016 Oct 24;5(10):e263. PubMed PMID: 27775701.

Lee JW, Huang BX, Kwon H, Rashid MA, Kharebava G, Desai A, Patnaik S, Marugan J, Kim HY. Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function. Nat Commun. 2016 Oct 19;7:13123. PubMed PMID: 27759003.

Su L, Zhang Z, Gan L, Jiang Q, Xiao P, Zou J, Li Q, Jiang H. Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease. Exp Mol Pathol. 2016 Oct;101(2):241-248. PubMed PMID: 27619161.

Salzman GS, Ackerman SD, Ding C, Koide A, Leon K, Luo R, Stoveken HM, Fernandez CG, Tall GG, Piao X, Monk KR, Koide S, Araç D. Structural basis for regulation of GPR56/ADGRG1 by its alternatively spliced extracellular domains. Neuron. 2016 Sep 21;91(6):1292-304. PubMed PMID: 27657451.

Glasco DM, Pike W, Qu Y, Reustle L, Misra K, Di Bonito M, Studer M, Fritzsch B, Goffinet AM, Tissir F, Chandrasekhar A. The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of facial branchiomotor neurons in mice. Dev Biol. 2016 Sep 1;417(1):40-9. PubMed PMID: 27395006.

Langenhan T, Piao X, Monk KR. Adhesion G protein-coupled receptors in nervous system development and disease. Nat Rev Neurosci. 2016 Sep;17(9):550-61. Review. PubMed PMID: 27466150.

Stoveken HM, Bahr LL, Anders MW, Wojtovich AP, Smrcka AV, Tall GG. Dihydromunduletone is a small-molecule selective adhesion G protein-coupled receptor antagonist. Mol Pharmacol. 2016 Sep;90(3):214-24. PubMed PMID: 27338081.

Küffer A, Lakkaraju AK, Mogha A, Petersen SC, Airich K, Doucerain C, Marpakwar R, Bakirci P, Senatore A, Monnard A, Schiavi C, Nuvolone M, Grosshans B, Hornemann S, Bassilana F, Monk KR, Aguzzi A. The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature. 2016 Aug 25;536(7617):464-8. PubMed PMID: 27501152.

Nijmeijer S, Vischer HF, Leurs R. Adhesion GPCRs in immunology. Biochem Pharmacol. 2016 Aug 15;114:88-102. Review. PubMed PMID: 27131861.

Fischer L, Wilde C, Schöneberg T, Liebscher I. Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133). BMC Genomics. 2016 Aug 11;17(1):609. PMID: 27516204.

Kitagaki J, Miyauchi S, Asano Y, Imai A, Kawai S, Michikami I, Yamashita M, Yamada S, Kitamura M, Murakami S. A Putative association of a single nucleotide polymorphism in GPR126 with aggressive periodontitis in a Japanese population. PLoS One. 2016 Aug 10;11(8):e0160765. PubMed PMID: 27509131.

Patat O, Pagin A, Siegfried A, Mitchell V, Chassaing N, Faguer S, Monteil L, Gaston V, Bujan L, Courtade-Saïdi M, Marcelli F, Lalau G, Rigot JM, Mieusset R, Bieth E. Truncating Mutations in the adhesion G protein-coupled receptor G2 gene ADGRG2 cause an X-linked congenital bilateral absence of vas deferens. Am J Hum Genet. 2016 Aug 4;99(2):437-42. PubMed PMID: 27476656.

Daria D, Kirsten N, Muranyi A, Mulaw M, Ihme S, Kechter A, Bullinger L, Döhner K, Döhner H, Feuring-Buske M, Buske C. GPR56 contributes to the development of acute myeloid leukemia in mice. Leukemia. 2016 Aug;30(8):1734-41. PubMed PMID: 27063597.

Vysokov NV, Silva JP, Lelianova VG, Ho C, Djamgoz MB, Tonevitsky AG, Ushkaryov YA. The mechanism of regulated release of Lasso/Teneurin-2. Front Mol Neurosci. 2016 Jul 22;9:59. PubMed PMID: 27499734; PubMed Central PMCID: PMC4956664.

Sumbayev VV, Silva IG, Blackburn J, Gibbs BF, Yasinska IM, Garrett MD, Tonevitsky AG, Ushkaryov YA. Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells. Oncotarget. 2016 Jul 19;7(29):45575-45583. PubMed PMID: 27322212.

Song Y, Li A, Zhang L, Duan L. Expression of G protein-coupled receptor 56 is associated with tumor progression in non-small-cell lung carcinoma patients. Onco Targets Ther. 2016 Jul 5;9:4105-12. PubMed PMID: 27462165.

Chen Z, Gao P, Li Z. Expression of G protein-coupled receptor 56 Is an unfavorable prognostic factor in osteosarcoma patients. Tohoku J Exp Med. 2016;239(3):203-11. PubMed PMID: 27396430.

Feng J, Xian Q, Guan T, Hu J, Wang M, Huang Y, So KF, Evans SM, Chai G, Goffinet AM, Qu Y, Zhou L. Celsr3 and Fzd3 organize a pioneer neuron scaffold to steer growing thalamocortical axons. Cereb Cortex. 2016 Jul;26(7):3323-34. PubMed PMID: 27170656.

Liu D, Li C, Trojanowicz B, Li X, Shi D, Zhan C, Wang Z, Chen L. CD97 promotion of gastric carcinoma lymphatic metastasis is exosome dependent. Gastric Cancer. 2016 Jul;19(3):754-66. PubMed PMID: 26233326.

Maiga A, Lemieux S, Pabst C, Lavallée VP, Bouvier M, Sauvageau G, Hébert J. Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets. Blood Cancer J. 2016 Jun 3;6(6):e431. PubMed PMID: 27258612.

Chiang NY, Chang GW, Huang YS, Peng YM, Hsiao CC, Kuo ML, Lin HH. Heparin interacts with adhesion-GPCR GPR56/ADGRG1, reduces receptor shedding, and promotes cell adhesion and motility. J Cell Sci. 2016 Jun 1;129(11):2156-69. PubMed PMID: 27068534.

Zhan YH, Luo QC, Zhang XR, Xiao NA, Lu CX, Yue C, Wang N, Ma QL. CELSR1 Is a positive regulator of endothelial cell migration and angiogenesis. Biochemistry (Mosc). 2016 Jun;81(6):591-9. PubMed PMID: 27301287.

Chang GW, Hsiao CC, Peng YM, Vieira Braga FA, Kragten NA, Remmerswaal EB, van de Garde MD, Straussberg R, König GM, Kostenis E, Knäuper V, Meyaard L, van Lier RA, van Gisbergen KP, Lin HH, Hamann J. The adhesion G protein-coupled receptor GPR56/ADGRG1 is an inhibitory receptor on human NK cells. Cell Rep. 2016 May 24;15(8)1757-70. PubMed PMID: 27184850.

Pabst C, Bergeron A, Lavallée VP, Yeh J, Gendron P, Norddahl GL, Krosl J, Boivin I, Deneault E, Simard J, Imren S, Boucher G, Eppert K, Herold T, Bohlander SK, Humphries K, Lemieux S, Hébert J, Sauvageau G, Barabé F. GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo. Blood. 2016 Apr 21;127(16):2018-27. PubMed PMID: 26834243.

Lee CS, Penberthy KK, Wheeler KM, Juncadella IJ, Vandenabeele P, Lysiak JJ, Ravichandran KS. Boosting apoptotic cell clearance by colonic epithelial cells attenuates inflammation in vivo. Immunity. 2016 Apr 19;44(4):807-20. PubMed PMID: 27037190.

Shi J, Zhang X, Wang S, Wang J, Du B, Wang Z, Liu M, Jiang W, Qian M, Ren H. Gpr97 is dispensable for metabolic syndrome but is involved in macrophage inflammation in high-fat diet-induced obesity in mice. Sci Rep. 2016 Apr 19;6:24649. PubMed PMID: 27089991.

Jackson VA, Mehmood S, Chavent M, Roversi P, Carrasquero M, Del Toro D, Seyit-Bremer G, Ranaivoson FM, Comoletti D, Sansom MS, Robinson CV, Klein R, Seiradake E. Super-complexes of adhesion GPCRs and neural guidance receptors. Nat Commun. 2016 Apr 19;7:11184. PubMed PMID: 27091502.

Yang J, Huang XF, Tong Y, Jin ZB. Targeted exome sequencing identified two novel truncation mutations in GPR98 causing Usher syndrome. Clin Experiment Ophthalmol. 2016 Apr;44(3):197-9. PubMed PMID: 26432996.

Jeon MS, Song SH, Yun J, Kang JY, Kim HP, Han SW, Kim TY. Aberrant epigenetic modifications of LPHN2 function as a potential cisplatin-specific biomarker for human gastrointestinal cancer. Cancer Res Treat. 2016 Apr;48(2):676-86. PubMed PMID: 26511811.

Winkler J, Prömel S. The adhesion GPCR latrophilin – a novel signaling cascade in oriented cell division and anterior-posterior polarity. Worm. 2016 Mar 30;5(2):e1170274. PubMed PMID: 27383912.

Holmfeldt P, Ganuza M, Marathe H, He B, Hall T, Kang G, Moen J, Pardieck J, Saulsberry AC, Cico A, Gaut L, McGoldrick D, Finkelstein D, Tan K, McKinney-Freeman S. Functional screen identifies regulators of murine hematopoietic stem cell repopulation. J Exp Med. 2016 Mar 7;213(3):433-49. PubMed PMID: 26880577.

Wang W, Jossin Y, Chai G, Lien WH, Tissir F, Goffinet AM. Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling. Nat Commun. 2016 Mar 4;7:10936. PubMed PMID: 26939553.

Wang S, Sun Z, Zhao W, Wang Z, Wu M, Pan Y, Yan H, Zhu J. CD97/ADGRE5 inhibits LPS induced NF-κB activation through PPAR-γ upregulation in macrophages. Mediators Inflamm. 2016;2016:1605948. PubMed PMID: 26997758.

Boyden SE, Desai A, Cruse G, Young ML, Bolan HC, Scott LM, Eisch AR, Long RD, Lee CR, Satorius CL, Pakstis AJ, Olivera A, Mullikin JC, Chouery E, Mégarbané A, Medlej-Hashim M, Kidd KK, Kastner DL, Metcalfe DD, Komarow HD. Vibratory urticaria associated with a missense variant in ADGRE2. N Engl J Med. 2016 Feb 18;374(7):656-63. PubMed PMID: 26841242.

Kishore A, Purcell RH, Nassiri-Toosi Z, Hall RA. Stalk-dependent and stalk-independent signaling by the adhesion G protein-coupled receptors GPR56 (ADGRG1) and BAI1 (ADGRB1). J Biol Chem. 2016 Feb 12;291(7):3385-94. PubMed PMID: 26710850.

Gonzalez-Garay ML, Aldrich MB, Rasmussen JC, Guilliod R, Lapinski PE, King PD, Sevick-Muraca EM. A novel mutation in CELSR1 is associated with hereditary lymphedema. Vasc Cell. 2016 Feb 5;8:1. PubMed PMID: 26855770.

Billings EA, Lee CS, Owen KA, D’Souza RS, Ravichandran KS, Casanova JE. The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria. Sci Signal. 2016 Feb 2;9(413):ra14. PubMed PMID: 26838550.

Wilde C, Fischer L, Lede V, Kirchberger J, Rothemund S, Schöneberg T, Liebscher I. The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist. FASEB J. 2016 Feb;30(2):666-73. PubMed PMID: 26499266.

Khor GH, Anisah Froemming GR, Zain RB, Abraham TM, Lin TK. Involvement of CELSR3 hypermethylation in primary oral squamous cell carcinoma. Asian Pac J Cancer Prev. 2016;17(1):219-23. PubMed PMID: 26838213.


Serban F, Artene SA, Georgescu AM, Purcaru SO, Tache DE, Alexandru O, Dricu A. Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker. Onco Targets Ther. 2015 Dec 16;8:3767-74. Review. PubMed PMID: 26719704.

Peeters MC, Fokkelman M, Boogaard B, Egerod KL, van de Water B, IJzerman AP, Schwartz TW. The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration. Cell Signal. 2015 Dec;27(12):2579-88. PubMed PMID: 26321231.

Wobus M, Bornhäuser M, Jacobi A, Kräter M, Otto O, Ortlepp C, Guck J, Ehninger G, Thiede C, Oelschlägel U. Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia. Oncotarget. 2015 Nov 17;6(36):38804-15. PubMed PMID: 26462154.

Dai S, Wang X, Li X, Cao Y. MicroRNA-139-5p acts as a tumor suppressor by targeting ELTD1 and regulating cell cycle in glioblastoma multiforme. Biochem Biophys Res Commun. 2015 Nov 13;467(2):204-10. PubMed PMID: 26449464.

Desai NA, Udani V. GPR56-related polymicrogyria: Clinicoradiologic profile of 4 patients. J Child Neural. 2015 Nov;30(13):1819-23. PubMed PMID: 25922261.

Lewis SM, Treacher DF, Edgeworth J, Mahalingam G, Brown CS, Mare TA, Stacey M, Beale R, Brown KA. Expression of CD11c and EMR2 on neutrophils: Potential diagnostic biomarkers for sepsis and systemic inflammation. Clin Exp Immunol. 2015 Nov;182(2):184-94. PubMed PMID: 26153037.

Müller A, Winkler J, Fiedler F, Sastradihardja T, Binder C, Schnabel R, Kugel J, Rothemund S, Hennig C, Schöneberg T, Prömel S. Oriented cell division in the C. elegans embryo is coordinated by G-protein signaling dependent on the adhesion GPCR LAT-1. PLoS Genet. 2015 Oct 27;11(10):e1005624. PubMed PMID: 26505631.

Niaudet C, Hofmann JJ, Mäe MA, Jung B, Gaengel K, Vanlandewijck M, Ekvärn E, Salvado MD, Mehlem A, Al Sayegh S, He L, Lebouvier T, Castro-Freire M, Katayama K, Hultenby K, Moessinger C, Tannenberg P, Cunha S, Pietras K, Laviña B, Hong J, Berg T, Betsholtz C. Gpr116 receptor regulates distinctive functions in pneumocytes and vascular endothelium. PLoS One. 2015 Sep 22;10(9):e0137949. PubMed PMID: 26394398.

Liebscher I, Monk KR, Schöneberg T. How to wake a giant. Oncotarget. 2015 Sep 15;6(27):23038-9. PubMed PMID: 26405160.

Lu YC, Nazarko OV, Sando R 3rd, Salzman GS, Südhof TC, Araç D. Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion. Structure. 2015 Sep 1;23(9):1678-91. PubMed PMID: 26235030.

Monk KR, Hamann J, Langenhan T, Nijmeijer S, Schoneberg T, Liebscher I. Adhesion GPCRs: From in vitro pharmacology to in vivo mechanisms. Mol Pharmacol. 2015 Sep;88(3):617-23. PubMed PMID: 25956432.

Langenhan T, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, Monk KR. Model organisms in GPCR research. Mol Pharmacol. 2015 Sep;88(3):596-603. PubMed PMID: 25979002.

He Y, Wang W, Xu L, Li L, Liu J, Feng M, Bu H. Immunohistochemical expression and prognostic significance of CD97 and its ligand DAF in human cervical squamous cell carcinoma. Int J Gynecol Pathol. 2015 Sep;34(5):473-479. PubMed PMID: 26107567.

Demberg LM, Rothemund S, Schöneberg T, Liebscher I. Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2. Biochem Biophys Res Commun. 2015 Aug 28;464(3):743-747. PubMed PMID: 26188515.

Zhang Y, Si Y, Ma N, Mei J. The RNA-binding protein PCBP2 inhibits Ang II-induced hypertrophy of cardiomyocytes though promoting GPR56 mRNA degeneration. Biochem Biophys Res Commun. 2015 Aug 28;464(3):679-684. PubMed PMID: 26116532.

Karner CM, Long F, Solnica-Krezel L, Monk KR, Gray RS. Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice. Hum Mol Genet. 2015 Aug 1;24(15):4365-73. PubMed PMID: 25954032.

Shi JP, Li XN, Zhang XY, Du B, Jiang WZ, Liu MY, Wang JJ, Wang ZG, Ren H, Qian M. Gpr97 is dispensable for inflammation in OVA-induced asthmatic mice. PLoS One. 2015 Jul 1;10(7):e0131461. PubMed PMID: 26132811.

Hsiao CC, Keysselt K, Chen HY, Sittig D, Hamann J, Lin HH, Aust G. The Adhesion GPCR CD97/ADGRE5 inhibits apoptosis. Int J Biochem Cell Biol. 2015 Jun 9;65:197-208. PubMed PMID: 26071181.

Vanhollebeke B, Stone OA, Bostaille N, Cho C, Zhou Y, Maquet E, Gauquier A, Cabochette P, Fukuhara S, Mochizuki N, Nathans J, Stainier DY. Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. Elife. 2015 Jun 8;4. PubMed PMID: 26051822.

Ravenscroft G, Nolent F, Rajagopalan S, Meireles AM, Paavola KJ, Gaillard D, Alanio E, Buckland M, Arbuckle S, Krivanek M, Maluenda J, Pannell S, Gooding R, Ong RW, Allcock RJ, Carvalho ED, Carvalho MD, Kok F, Talbot WS, Melki J, Laing NG. Mutations of GPR126 are responsible for severe arthrogryposis multiplex congenita. Am J Hum Genet. 2015 Jun 4;96(6):955-61. PubMed PMID: 26004201.

Scholz N, Gehring J, Guan C, Ljaschenko D, Fischer R, Lakshmanan V, Kittel RJ, Langenhan T. The adhesion GPCR Latrophilin/CIRL shapes mechanosensation. Cell Rep. 2015 May 12;11(6):866-74. PubMed PMID: 25937282.

Stoveken HM, Hajduczok AG, Xu L, Tall GG. Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist. Proc Natl Acad Sci U S A. 2015 May 12;112(19):6194-9. PubMed PMID: 25918380.

Ariestanti DM, Ando H, Hirose S, Nakamura N. Targeted disruption of Ig-Hepta/Gpr116 causes emphysema-like symptoms that are associated with alveolar macrophage activation. J Biol Chem. 2015 Apr 24;290(17):11032-40. PubMed PMID: 25778400.

Jackson VA, Del Toro D, Carrasquero M, Roversi P, Harlos K, Klein R, Seiradake E. Structural basis of latrophilin-FLRT interaction. Structure. 2015 Apr 7;23(4):774-81. PubMed PMID: 25728924.

Ressl S, Vu BK, Vivona S, Martinelli DC, Südhof TC, Brunger AT. Structures of C1q-like proteins reveal unique features among the C1q/TNF superfamily. Structure. 2015 Apr 7;23(4):688-99. PubMed PMID: 25752542.

Zhu D, Li C, Swanson AM, Villalba RM, Guo J, Zhang Z, Matheny S, Murakami T, Stephenson JR, Daniel S, Fukata M, Hall RA, Olson JJ, Neigh GN, Smith Y, Rainnie DG, Van Meir EG. BAI1 regulates spatial learning and synaptic plasticity in the hippocampus. J Clin Invest. 2015 Apr 1;125(4):1497-508. PubMed PMID: 25751059.

Ohta S, Sakaguchi S, Kobayashi Y, Mizuno N, Tago K, Itoh H. Agonistic antibodies reveal the function of GPR56 in human glioma U87-MG cells. Biol Pharm Bull. 2015;38(4):594-600. PubMed PMID: 25832639.

Santos-Silva R, Passas A, Rocha C, Figueiredo R, Mendes-Ribeiro J, Fernandes S, Biskup S, Leão M. Bilateral frontoparietal polymicrogyria: a novel GPR56 mutation and an unusual phenotype. Neuropediatrics. 2015 Apr;46(2):134-8. PubMed PMID: 25642806.

Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev. 2015 Apr;67(2):338-67. PubMed PMID: 25713288.

Santos-Silva R, Passas A, Rocha C, Figueiredo R, Mendes-Ribeiro J, Fernandes S, Biskup S, Leão M. Bilateral frontoparietal polymicrogyria: a novel GPR56 mutation and an unusual phenotype. Neuropediatrics. 2015 Apr;46(2):134-8. PubMed PMID: 25642806.

Rao TN, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN, Serwold T, Pimanda JE, Wagers AJ. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Stem Cell Res. 2015 Feb 18;14(3):307-322. PubMed PMID: 25840412.

Harty BL, Krishnan A, Sanchez NE, Schiöth HB, Monk KR. Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. BMC Genomics. 2015 Feb 8;16:62. PubMed PMID: 25715737.

Wang Y, Fan X, Zhang W, Zhang C, Wang J, Jiang T, Wang L. Deficiency of very large G-protein-coupled receptor-1 is a risk factor of tumor-related epilepsy: a whole transcriptome sequencing analysis. J Neurooncol. 2015 Feb;121(3):609-16. PubMed PMID: 25511798.

Petersen SC, Luo R, Liebscher I, Giera S, Jeong SJ, Mogha A, Ghidinelli M, Feltri ML, Schöneberg T, Piao X, Monk KR. The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with Laminin-211. Neuron. 2015 Feb 18;85(4):755-69. PubMed PMID: 25695270.

Xu JF, Yang GH, Pan XH, Zhang SJ, Zhao C, Qiu BS, Gu HF, Hong JF, Cao L, Chen Y, Xia B, Bi Q, Wang YP. Association of GPR126 gene polymorphism with adolescent idiopathic scoliosis in Chinese populations. Genomics. 2015 Feb;105(2):101-7. PubMed PMID: 25479386.

He Z, Wu H, Jiao Y, Zheng J. Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer. Oncol Lett. 2015 Feb;9(2):793-797. PubMed PMID: 25624904.

Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR. The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα(12/13) and RhoA. Nat Commun. 2015 Jan 21;6:6122. PubMed PMID: 25607772.

Giera S, Deng Y, Luo R, Ackerman SD, Mogha A, Monk KR, Ying Y, Jeong SJ, Makinodan M, Bialas AR, Chang BS, Stevens B, Corfas G, Piao X. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015 Jan 21;6:6121. PubMed PMID: 25607655.

Organisti C, Hein I, Grunwald Kadow IC, Suzuki T. Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance. Genes Cells. 2015 Jan;20(1):50-67. PubMed PMID: 25440577.

Posokhova E, Shukla A, Seaman S, Volate S, Hilton MB, Wu B, Morris H, Swing DA, Zhou M, Zudaire E, Rubin JS, St Croix B. GPR124 functions as a WNT7-specific
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Solaimani Kartalaei P, Yamada-Inagawa T, Vink CS, de Pater E, van der Linden R, Marks-Bluth J, van der Sloot A, van den Hout M, Yokomizo T, van Schaick-Solernó ML, Delwel R, Pimanda JE, van IJcken WF, Dzierzak E. Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation. J Exp Med. 2015 Jan 12;212(1):93-106. PubMed PMID: 25547674.


Liebscher I, Schön J, Petersen SC, Fischer L, Auerbach N, Demberg LM, Mogha A, Cöster M, Simon KU, Rothemund S, Monk KR, Schöneberg T. A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133. Cell Rep. 2014 Dec 24;9(6):2018-26. PubMed PMID: 25533341.

Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014 Dec;1333(1):43-64. PubMed PMID: 25424900.

Wang XJ, Zhang DL, Xu ZG, Ma ML, Wang WB, Li LL, Han XL, Huo Y, Yu X, Sun JP. Understanding cadherin EGF LAG seven-pass G-type receptors. J Neurochem. 2014 Dec;131(6):699-711. PubMed PMID: 25280249.

Favara DM, Banham AH, Harris AL. A review of ELTD1, a pro-angiogenic adhesion GPCR. Biochem Soc Trans. 2014 Dec 1;42(6):1658-64. PubMed PMID: 25399586.

Yang TY, Chiang NY, Tseng WY, Pan HL, Peng YM, Shen JJ, Wu KA, Kuo ML, Chang GW, Lin HH. Expression and immunoaffinity purification of recombinant soluble human GPR56 protein for the analysis of GPR56 receptor shedding by ELISA. Protein Expr Purif. 2014 Nov 28. pii: S1046-5928(14)00274-5. PubMed PMID: 25437104.

White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM. G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15756-61. PubMed PMID: 25336758.

Hsiao CC, Wang WC, Kuo WL, Chen HY, Chen TC, Hamann J, Lin HH. CD97 inhibits cell migration in human fibrosarcoma cells by modulating TIMP-2/MT1- MMP/MMP-2 activity – role of GPS autoproteolysis and functional cooperation between the N- and C-terminal fragments. FEBS J. 2014 Nov;281(21):4878-91. PubMed PMID: 25174588.

Zhou Y, Nathans J. Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling. Dev Cell. 2014 Oct 27;31(2):248-56. PubMed PMID: 25373781.

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Chai G, Zhou L, Manto M, Helmbacher F, Clotman F, Goffinet AM, Tissir F. Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nat Neurosci. 2014 Sep;17(9):1171-9. PubMed PMID: 25108913.

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Luo R, Jeong SJ, Yang A, Wen M, Saslowsky DE, Lencer WI, Arac D, Piao X. Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation. PLoS One. 2014 Jun 20;9(6):e100043. PubMed PMID: 24949629.

Mazaheri F, Breus O, Durdu S, Haas P, Wittbrodt J, Gilmour D, Peri F. Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia. Nat Commun. 2014 Jun 5;5:4046. PubMed PMID: 24898390.

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Wang Y, Cho SG, Wu X, Siwko S, Liu M. G-protein coupled receptor 124 (GPR124) in endothelial cells regulates vascular endothelial growth factor (VEGF)-induced tumor angiogenesis. Curr Mol Med. 2014 May;14(4):543-54. PubMed PMID: 24730523.

Das S, Sarkar A, Ryan KA, Fox S, Berger AH, Juncadella IJ, Bimczok D, Smythies LE, Harris PR, Ravichandran KS, Crowe SE, Smith PD, Ernst PB. Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells. FASEB J. 2014 May;28(5):2214-24. PubMed PMID: 24509909.

Legrand F, Tomasevic N, Simakova O, Richard Lee CC, Wang Z, Raffeld M, Makiya MA, Palath V, Leung J, Baer M, Yarranton G, Maric I, Bebbington C, Klion AD. The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): A novel therapeutic target for eosinophilic disorders. J Allergy Clin Immunol. 2014 May;133(5):1439-1447.e8. PubMed PMID: 24530099.

Stephenson JR, Purcell RH, Hall RA. The BAI subfamily of adhesion GPCRs: synaptic regulation and beyond. Trends Pharmacol Sci. 2014 Apr;35(4):208-215. PubMed PMID: 24642458.

Lei Y, Zhu H, Yang W, Ross ME, Shaw GM, Finnell RH. Identification of novel CELSR1 mutations in spina bifida. PLoS One. 2014 Mar 14;9(3):e92207. PubMed PMID: 24632739.

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Hamoud N, Tran V, Croteau LP, Kania A, Coté JF. G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3745-50. PubMed PMID: 24567399.

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Yang L, Friedland SC, Corson N, Xu L. GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2. Cancer Res. 2014 Feb 15;74(4):1022-31. PubMed PMID: 24356421.

Bae BI, Tietjen I, Atabay KD, Evrony GD, Johnson MB, Asare E, Wang PP, Murayama AY, Im K, Lisgo SN, Overman L, Sestan N, Chang BS, Barkovich AJ, Grant PE, Topcu M, Politsky J, Okano H, Piao X, Walsh CA. Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science. 2014 Feb 14;343(6172):764-8. PubMed PMID: 24531968.

Huang LC, Hueng DY. CD97 and glioma invasion. J Neurosurg. 2014 Feb;120(2):579-80. PubMed PMID: 24286141.

Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, Dang SY, Zhang GH, Zhang HX, Kuang Y, Fei J, Gu MM, Rong WF, Wang ZG. Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency. World J Gastroenterol. 2014 Jan 14;20(2):498-508. PubMed PMID: 24574718.


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Valtcheva N, Primorac A, Jurisic G, Hollmen M, Detmar M. The orphan adhesion G protein coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. J Biol Chem. 2013 Dec 13;288(50):35736-48. PubMed PMID: 24178298.

Wu MP, Doyle JR, Barry B, Beauvais A, Rozkalne A, Piao X, Lawlor MW, Kopin AS, Walsh CA, Gussoni E. GPR56 promotes myoblast fusion through SRE- and NFAT-mediated signaling but is not essential for muscle development in vivo. FEBS J. 2013 Dec;280(23):6097-113. PubMed PMID: 24102982.

Shin D, Lin ST, Fu YH, Ptácek LJ. Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19101-6. PubMed PMID: 24191038.

Mogha A, Benesh AE, Patra C, Engel FB, Schöneberg T, Liebscher I, Monk KR. Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation. J Neurosci. 2013 Nov 13;33(46):17976-85. PubMed PMID: 24227709.

Geng FS, Abbas L, Baxendale S, Holdsworth CJ, Swanson AG, Slanchev K, Hammerschmidt M, Topczewski J, Whitfield TT. Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development. 2013 Nov;140(21):4362-74. PubMed PMID: 24067352.

Park SJ, Lee KP, Kang S, Chung HY, Bae YS, Okajima F, Im DS. Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer cells. Cell Signal. 2013 Nov;25(11):2147-54. PubMed PMID: 23838008.

Tang X, Jin R, Qu G, Wang X, Li Z, Yuan Z, Zhao C, Siwko S, Shi T, Wang P, Xiao J, Liu M, Luo J. GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Gαq-p63RhoGEF-Rho GTPase pathway. Cancer Res. 2013 Oct 15;73(20):6206-18. PubMed PMID: 24008316.

Wang JJ, Zhang LL, Zhang HX, Shen CL, Lu SY, Kuang Y, Wan YH, Wang WG, Yan HM, Dang SY, Fei J, Jin XL, Wang ZG. Gpr97 is essential for the follicular versus marginal zone B-lymphocyte fate decision. Cell Death Dis. 2013 Oct 10;4:e853. PubMed PMID: 24113187.

Patra C, van Amerongen MJ, Ghosh S, Ricciardi F, Sajjad A, Novoyatleva T, Mogha A, Monk KR, Mühlfeld C, Engel FB. Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16898-903. PubMed PMID: 24082093.

Bridges JP, Ludwig MG, Mueller M, Kinzel B, Sato A, Xu Y, Whitsett JA, Ikegami M. Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size. Am J Respir Cell Mol Biol. 2013 Sep;49(3):348-57. PubMed PMID: 23590306.

Saito Y, Kaneda K, Suekane A, Ichihara E, Nakahata S, Yamakawa N, Nagai K, Mizuno N, Kogawa K, Miura I, Itoh H, Morishita K. Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56. Leukemia. 2013 Aug;27(8):1637-49. PubMed PMID: 23478665.

Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, Mangala LS, Wu SY, Pradeep S, Li D, Han C, Dalton H, Lopez-Berestein G, Tuynman JB, Mortensen N, Li JL, Patient R, Sood AK, Banham AH, Harris AL, Buffa FM. A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. Cancer Cell. 2013 Aug 12;24(2):229-41. PubMed PMID: 23871637.

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Prömel S, Langenhan T, Araç D. Matching structure with function: the GAIN domain of Adhesion-GPCR and PKD1-like proteins. Trends Pharmacol Sci. 2013 Aug;34(8):470-8. PubMed PMID: 23850273.

Glenn TD, Talbot WS. Analysis of Gpr126 function defines distinct mechanisms controlling the initiation and maturation of myelin. Development. 2013 Aug;140(15):3167-75. PubMed PMID: 23804499.

Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, Isope P, Vodjdani G, Heintz N, Selimi F. The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons. Mol Psychiatry. 2013 Aug;18(8):943-50. PubMed PMID: 23628982.

Liebscher I, Schöneberg T, Prömel S. Progress in demystification of adhesion G protein-coupled receptors. Biol Chem. 2013 Aug 1;394(8):937-50. PubMed PMID: 23518449.

Li X, Roszko I, Sepich DS, Ni M, Hamm HE, Marlow FL, Solnica-Krezel L. Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Development. 2013 Jul;140(14):3028-39. PubMed PMID: 23821037.

Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S. Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D. PLoS One. 2013 Jul 29;8(7):e69451. PubMed PMID: 23922714.

Jeong SJ, Luo R, Singer K, Giera S, Kreidberg J, Kiyozumi D, Shimono C, Sekiguchi K, Piao X. GPR56 functions together with α3β1 integrin in regulating cerebral cortical development. PLoS One. 2013 Jul 9;8(7):e68781. PubMed PMID: 23874761.

Aust G, Kerner C, Gonsior S, Sittig D, Schneider H, Buske P, Scholz M, Dietrich N, Oldenburg S, Karpus ON, Galle J, Amasheh S, Hamann J. Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth. Mol Biol Cell. 2013 Jul;24(14):2256-2268. PubMed PMID: 23676664.

Kou I, Takahashi Y, Johnson TA, Takahashi A, Guo L, Dai J, Qiu X, Sharma S, Takimoto A, Ogura Y, Jiang H, Yan H, Kono K, Kawakami N, Uno K, Ito M, Minami S, Yanagida H, Taneichi H, Hosono N, Tsuji T, Suzuki T, Sudo H, Kotani T, Yonezawa I, Londono D, Gordon D, Herring JA, Watanabe K, Chiba K, Kamatani N, Jiang Q, Hiraki Y, Kubo M, Toyama Y, Tsunoda T, Wise CA, Qiu Y, Shukunami C, Matsumoto M, Ikegawa S. Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis. Nat Genet. 2013 Jun;45(6):676-9. PubMed PMID: 23666238.

Southern C, Cook JM, Neetoo-Isseljee Z, Taylor DL, Kettleborough CA, Merritt A, Bassoni DL, Raab WJ, Quinn E, Wehrman TS, Davenport AP, Brown AJ, Green A, Wigglesworth MJ, Rees S. Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609. PubMed PMID: 23396314.

Fallgatter AJ, Ehlis AC, Dresler T, Reif A, Jacob CP, Arcos-Burgos M, Muenke M, Lesch KP. Influence of a Latrophilin 3 (LPHN3) risk haplotype on event-related potential measures of cognitive response control in attention-deficit hyperactivity disorder (ADHD). Eur Neuropsychopharmacol. 2013 Jun;23(6):458-68. PubMed PMID: 23245769.

Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B. Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116. Cell Rep. 2013 May 30;3(5):1457-64. PubMed PMID: 23684610.

Ward Y, Lake R, Martin PL, Killian K, Salerno P, Wang T, Meltzer P, Merino M, Cheng SY, Santoro M, Garcia-Rostan G, Kelly K. CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model. Oncogene. 2013 May 30;32(22):2726-38. PubMed PMID: 22797060.22797060.

Langenhan T, Aust G, Hamann J. Sticky signaling–adhesion class G protein-coupled receptors take the stage. Sci Signal. 2013 May 21;6(276):re3. PubMed PMID: 23695165.

Wang W, DA R, Wang M, Wang T, Qi L, Jiang H, Chen W, Li Q. Expression of brain-specific angiogenesis inhibitor 1 is inversely correlated with pathological grade, angiogenesis and peritumoral brain edema in human astrocytomas. Oncol Lett. 2013 May;5(5):1513-1518. PubMed PMID: 23761815.

Hochreiter-Hufford AE, Lee CS, Kinchen JM, Sokolowski JD, Arandjelovic S, Call JA, Klibanov AL, Yan Z, Mandell JW, Ravichandran KS. Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature. 2013 May 9;497(7448):263-7. PubMed PMID: 23615608.

Richter GH, Fasan A, Hauer K, Grunewald TG, Berns C, Rössler S, Naumann I, Staege MS, Fulda S, Esposito I, Burdach S. G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1. J Pathol. 2013 May;230(1):70-81. PubMed PMID: 23338946.

Huarcaya Najarro E, Ackley BD. C. elegans fmi-1/flamingo and Wnt pathway components interact genetically to control the anteroposterior neurite growth of the VD GABAergic neurons. Dev Biol. 2013 May 1;377(1):224-35. PubMed PMID: 23376536.

Sun JP, Li R, Ren HZ, Xu AT, Yu X, Xu ZG. The very large G protein coupled receptor (Vlgr1) in hair cells. J Mol Neurosci. 2013 May;50(1):204-14. PubMed PMID: 23180093

Duman JG, Tzeng CP, Tu YK, Munjal T, Schwechter B, Ho TS, Tolias KF. The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites. J Neurosci. 2013 Apr 17;33(16):6964-78. PubMed PMID: 23595754.

Karpus ON, Veninga H, Hoek RM, Flierman D, van Buul JD, Vandenakker CC, Vanbavel E, Medof ME, van Lier RA, Reedquist KA, Hamann J. Shear stress-dependent downregulation of the Adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55. J Immunol. 2013 Apr 1;190(7):3740-8. PubMed PMID: 23447688.

García-García G, Besnard T, Baux D, Vaché C, Aller E, Malcolm S, Claustres M, Millan JM, Roux AF. The contribution of GPR98 and DFNB31 genes to a Spanish Usher syndrome type 2 cohort. Mol Vis. 2013;19:367-73. PubMed PMID: 23441107.

Quattrocchi CC, Zanni G, Napolitano A, Longo D, Cordelli DM, Barresi S, Randisi F, Valente EM, Verdolotti T, Genovese E, Specchio N, Vitiello G, Spiegel R, Bertini E, Bernardi B. Conventional magnetic resonance imaging and diffusion tensor imaging studies in children with novel GPR56 mutations: further delineation of a cobblestone-like phenotype. Neurogenetics. 2013 Feb;14(1):77-83. PubMed PMID: 23274687.

Singer K, Luo R, Jeong SJ, Piao X. GPR56 and the developing cerebral cortex: Cells, matrix, and neuronal migration. Mol Neurobiol. 2013 Feb;47(1):186-96. PubMed PMID: 23001883.

Towner RA, Jensen RL, Colman H, Vaillant B, Smith N, Casteel R, Saunders D, Gillespie DL, Silasi-Mansat R, Lupu F, Giles CB, Wren JD. ELTD1, a potential new biomarker for gliomas. Neurosurgery. 2013 Jan;72(1):77-91. PubMed PMID: 23096411.


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Cork SM, Kaur B, Devi NS, Cooper L, Saltz JH, Sandberg EM, Kaluz S, Van Meir EG. A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1. Oncogene. 2012 Dec 13;31(50):5144-52. PubMed PMID: 22330140.

Weinsheimer S, Brettman AD, Pawlikowska L, Wu DC, Mancuso MR, Kuhnert F, Lawton MT, Sidney S, Zaroff JG, McCulloch CE, Young WL, Kuo C, Kim H. G protein-coupled receptor 124 (GPR124) gene polymorphisms and risk of brain arteriovenous malformation. Transl Stroke Res. 2012 Dec;3(4):418-427. PubMed PMID: 23329986.

Paavola KJ, Hall RA. Adhesion g protein-coupled receptors: signaling, pharmacology, and mechanisms of activation. Mol Pharmacol. 2012 Nov;82(5):777-83. PubMed PMID: 22821233

Nie T, Hui X, Gao X, Li K, Lin W, Xiang X, Ding M, Kuang Y, Xu A, Fei J, Wang Z, Wu D. Adipose tissue deletion of Gpr116 impairs insulin sensitivity through modulation of adipose function. FEBS Lett. 2012 Oct 19;586(20):3618-25. PubMed PMID: 22971422.

Feng J, Xu Y, Wang M, Ruan Y, So KF, Tissir F, Goffinet A, Zhou L. A role for atypical cadherin celsr3 in hippocampal maturation and connectivity. J Neurosci. 2012 Oct 3;32(40):13729-43. PubMed PMID: 23035085.

Prömel S, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Grosse J, Schöneberg T, Russ AP, Langenhan T. Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Dev Dyn. 2012 Oct;241(10):1591-602. PubMed PMID: 22837050.

Badiali L, Cedernaes J, Olszewski PK, Nylander O, Vergoni AV, Schiöth HB. Adhesion GPCRs are widely expressed throughout the subsections of the gastrointestinal tract. BMC Gastroenterol. 2012 Sep 25;12(1):134. PubMed PMID: 23009096.

Lange M, Norton W, Coolen M, Chaminade M, Merker S, Proft F, Schmitt A, Vernier P, Lesch KP, Bally-Cuif L. The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development. Mol Psychiatry. 2012 Sep;17(9):946-54. PubMed PMID: 22508465.

Jeong SJ, Luo R, Li S, Strokes N, Piao X. Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex. J Comp Neurol. 2012 Sep 1;520(13):2930-40. PubMed PMID: 22351047.

Prömel S, Frickenhaus M, Hughes S, Mestek L, Staunton D, Woollard A, Vakonakis I, Schöneberg T, Schnabel R, Russ AP, Langenhan T. The GPS motif is a molecular switch for bimodal activities of adhesion class G protein-coupled receptors. Cell Rep. 2012 Aug 30;2(2):321-31. PubMed PMID: 22938866.

Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T, Li L. Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell. 2012 Jul 20;150(2):351-65. PubMed PMID: 22817897.

Liu D, Trojanowicz B, Ye L, Li C, Zhang L, Li X, Li G, Zheng Y, Chen L. The invasion and metastasis promotion role of CD97 small isoform in gastric carcinoma. PLoS One. 2012;7(6):e39989. PubMed PMID: 22768192.

Xiao J, Jiang H, Zhang R, Fan G, Zhang Y, Jiang D, Li H. Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1. PLoS One. 2012;7(5):e35779. PubMed PMID: 22606234.

Nishimura T, Honda H, Takeichi M. Planar cell polarity links axes of spatial dynamics in neural-tube closure. Cell. 2012 May 25;149(5):1084-97. PubMed PMID: 22632972.

Chan YF, Jones FC, McConnell E, Bryk J, Bünger L, Tautz D. Parallel selection mapping using artificially selected mice reveals body weight control loci. Curr Biol. 2012 May 8;22(9):794-800. PubMed PMID: 22445301.

Yang L, Xu L. GPR56 in cancer progression: current status and future perspective. Future Oncol. 2012 Apr;8(4):431-40. Review. PubMed PMID: 22515446.

Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X. Signaling property study of adhesion G-protein-coupled receptors. FEBS Lett. 2012 Apr 24;586(8):1214-9. PubMed PMID: 22575658.

Huang YS, Chiang NY, Hu CH, Hsiao CC, Cheng KF, Tsai WP, Yona S, Stacey M, Gordon S, Chang GW, Lin HH. Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains. Mol Cell Biol. 2012 Apr;32(8):1408-20. PubMed PMID: 22310662.

Najarro EH, Wong L, Zhen M, Carpio EP, Goncharov A, Garriga G, Lundquist EA, Jin Y, Ackley BD. Caenorhabditis elegans flamingo cadherin fmi-1 regulates GABAergic neuronal development. J Neurosci. 2012 Mar 21;32(12):4196-211. PubMed PMID: 22442082.

Boucard AA, Ko J, Südhof TC. High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex. J Biol Chem. 2012 Mar 16;287(12):9399-413. PubMed PMID: 22262843.

O’Sullivan ML, de Wit J, Savas JN, Comoletti D, Otto-Hitt S, Yates JR 3rd, Ghosh A. FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. Neuron. 2012 Mar 8;73(5):903-10. PubMed PMID: 22405201.

Tesmer JJ. A GAIN in understanding autoproteolytic G protein-coupled receptors and polycystic kidney disease proteins. EMBO J. 2012 Mar 21;31(6):1334-5. PubMed PMID: 22388517.

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Vallon M, Aubele P, Janssen KP, Essler M. Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase. Biochem J. 2012 Feb 1;441(3):937-44. PubMed PMID: 22013897.

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Krishnan A, Almén MS, Fredriksson R, Schiöth HB. The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi. PLoS One. 2012;7(1):e29817. PubMed PMID: 22238661.


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Ward Y, Lake R, Yin JJ, Heger CD, Raffeld M, Goldsmith PK, Merino M, Kelly K. LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells. Cancer Res. 2011 Dec 1;71(23):7301-11. PubMed PMID: 21978933.

Rutkowski MJ, Sughrue ME, Kane AJ, Kim JM, Bloch O, Parsa AT. Epidermal growth factor module-containing mucin-like receptor 2 is a newly identified adhesion G protein-coupled receptor associated with poor overall survival and an invasive phenotype in glioblastoma. J Neurooncol. 2011 Nov;105(2):165-71. PubMed PMID: 21503828.

Peng YM, van de Garde MD, Cheng KF, Baars PA, Remmerswaal EB, van Lier RA, Mackay CR, Lin HH, Hamann J. Specific expression of GPR56 by human cytotoxic lymphocytes. J Leukoc Biol. 2011 Oct;90(4):735-40. PubMed PMID: 21724806.

Veninga H, Hoek RM, de Vos AF, de Bruin AM, An FQ, van der Poll T, van Lier RA, Medof ME, Hamann J. A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense. PLoS One. 2011;6(10):e24431. PubMed PMID: 21984892.

Zhu D, Hunter SB, Vertino PM, Van Meir EG. Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1. Cancer Res. 2011 Sep 1;71(17):5859-70. PubMed PMID: 21724586.

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Gordon S, Hamann J, Lin HH, Stacey M. F4/80 and the related adhesion-GPCRs. Eur J Immunol. 2011 Sep;41(9):2472-6. Review. PubMed PMID: 21952799.

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Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes RO, Xu L. GPR56 Regulates VEGF production and angiogenesis during melanoma progression. Cancer Res. 2011 Aug 15;71(16):5558-68. PubMed PMID: 21724588.

Sokolowski JD, Nobles SL, Heffron DS, Park D, Ravichandran KS, Mandell JW. Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: implications for its dual function as an apoptotic engulfment receptor. Brain Behav Immun. 2011 Jul;25(5):915-21. PubMed PMID: 20888903.

Silva JP, Lelianova VG, Ermolyuk YS, Vysokov N, Hitchen PG, Berninghausen O, Rahman MA, Zangrandi A, Fidalgo S, Tonevitsky AG, Dell A, Volynski KE, Ushkaryov YA. Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12113-8. PubMed PMID: 21724987.

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Izutsu T, Konda R, Sugimura J, Iwasaki K, Fujioka T. Brain-specific angiogenesis inhibitor 1 is a putative factor for inhibition of neovascular formation in renal cell carcinoma. J Urol. 2011 Jun;185(6):2353-8. PubMed PMID: 21511296.

Xiao J, Jiang H, Zhang R, Fan G, Zhang Y, Jiang D, Li H. Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1. PLoS One. 2012;7(5):e35779. PubMed PMID: 22606234.

Chiang NY, Hsiao CC, Huang YS, Chen HY, Hsieh IJ, Chang GW, Lin HH. Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms. J Biol Chem. 2011 Apr 22;286(16):14215-25. PubMed PMID: 21349 848.

Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B. GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64. PubMed PMID: 21421844.

Hakeda-Suzuki S, Berger-Müller S, Tomasi T, Usui T, Horiuchi SY, Uemura T, Suzuki T. Golden Goal collaborates with Flamingo in conferring synaptic-layer specificity in the visual system. Nat Neurosci. 2011 Mar;14(3):314-23. PubMed PMID: 21317905.

Rani M, Dikhit MR, Sahoo GC, Das P. Comparative domain modeling of human EGF-like module EMR2 and study of interaction of the fourth domain of EGF with chondroitin 4-sulphate. J Biomed Res. 2011 Mar;25(2):100-10. PubMed PMID: 23554678.

Davies JQ, Lin HH, Stacey M, Yona S, Chang GW, Gordon S, Hamann J, Campo L, Han C, Chan P, Fox SB. Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival. Oncol Rep. 2011 Mar;25(3):619-27. PubMed PMID: 21174063.

Veninga H, de Groot DM, McCloskey N, Owens BM, Dessing MC, Verbeek JS, Nourshargh S, van Eenennaam H, Boots AM, Hamann J. CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism. J Leukoc Biol. 2011 Mar;89(3):413-21. PubMed PMID: 21169517.

Ribasés M, Ramos-Quiroga JA, Sánchez-Mora C, Bosch R, Richarte V, Palomar G, Gastaminza X, Bielsa A, Arcos-Burgos M, Muenke M, Castellanos FX, Cormand B, Bayés M, Casas M. Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study. Genes Brain Behav. 2011 Mar;10(2):149-57. PubMed PMID: 21040458.

Anderson KD, Pan L, Yang XM, Hughes VC, Walls JR, Dominguez MG, Simmons MV, Burfeind P, Xue Y, Wei Y, Macdonald LE, Thurston G, Daly C, Lin HC, Economides AN, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gale NW. Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2807-12. PubMed PMID: 21282641.

Bolliger MF, Martinelli DC, Südhof TC. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2534-9. PubMed PMID: 21262840.

Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, Sifri CD, Ravichandran KS, Ernst PB, Casanova JE. Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2136-41. PubMed PMID: 21245295.

Hsiao CC, Chen HY, Chang GW, Lin HH. GPS autoproteolysis is required for CD97 to up-regulate the expression of N-cadherin that promotes homotypic cell-cell aggregation. FEBS Lett. 2011 Jan 21;585(2):313-8. PubMed PMID: 21156175.

Martinez AF, Muenke M, Arcos-Burgos M. From the black widow spider to human behavior: Latrophilins, a relatively unknown class of G protein-coupled receptors, are implicated in psychiatric disorders. Am J Med Genet B Neuropsychiatr Genet. 2011 Jan;156B(1):1-10. PubMed PMID: 21184579.


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Chen G, Yang L, Begum S, Xu L. GPR56 is essential for testis development and male fertility in mice. Dev Dyn. 2010 Dec;239(12):3358-67. PubMed PMID: 20981830.

Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, Domené S, Vélez JI, Karkera JD, Balog J, Berg K, Kleta R, Gahl WA, Roessler E, Long R, Lie J, Pineda D, Londono AC, Palacio JD, Arbelaez A, Lopera F, Elia J, Hakonarson H, Johansson S, Knappskog PM, Haavik J, Ribases M, Cormand B, Bayes M, Casas M, Ramos-Quiroga JA, Hervas A, Maher BS, Faraone SV, Seitz C, Freitag CM, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A, Romanos J, Renner T, Jacob C, Lesch KP, Swanson J, Vortmeyer A, Bailey-Wilson JE, Castellanos FX, Muenke M. A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry. 2010 Nov;15(11):1053-66. PubMed PMID: 20157310.

Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science. 2010 Nov 12;330(6006):985-9. PubMed PMID: 21071672.

Serova OV, Popova NV, Petrenko AG, Deyev IE. Association of the subunits of the calcium-independent receptor of α-latrotoxin. Biochem Biophys Res Commun. 2010 Nov 26;402(4):658-62. PubMed PMID: 20971062.

Waller-Evans H, Prömel S, Langenhan T, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Davies B, Aparicio SA, Grosse J, Russ AP. The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. PLoS One. 2010 Nov 18;5(11):e14047. PubMed PMID: 21124978.

Steimel A, Wong L, Najarro EH, Ackley BD, Garriga G, Hutter H. The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons in C. elegans. Development. 2010 Nov;137(21):3663-73. PubMed PMID: 20876647.

Bahi-Buisson N, Poirier K, Boddaert N, Fallet-Bianco C, Specchio N, Bertini E, Caglayan O, Lascelles K, Elie C, Rambaud J, Baulac M, An I, Dias P, des Portes V, Moutard ML, Soufflet C, El Maleh M, Beldjord C, Villard L, Chelly J. GPR56-related bilateral frontoparietal polymicrogyria: further evidence for an overlap with the cobblestone complex. Brain. 2010 Nov;133(11):3194-209. PubMed PMID: 20929962.

Sokolowski JD, Nobles SL, Heffron DS, Park D, Ravichandran KS, Mandell JW. Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: Implications for its dual function as an apoptotic engulfment receptor. Brain Behav Immun. 2010 Oct 1. PubMed PMID: 20888903.

Formstone CJ, Moxon C, Murdoch J, Little P, Mason I. Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein. Mol Cell Neurosci. 2010 Jul;44(3):210-22. PubMed PMID: 20353824.

Han SL, Xu C, Wu XL, Li JL, Liu Z, Zeng QQ. The impact of expressions of CD97 and its ligand CD55 at the invasion front on prognosis of rectal adenocarcinoma. Int J Colorectal Dis. 2010 Jun;25(6):695-702. PubMed PMID: 20339853.

Okajima D, Kudo G, Yokota H. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. J Recept Signal Transduct Res. 2010 Jun;30(3):143-53. PubMed PMID: 20367554.

Liu D, Trojanowicz B, Radestock Y, Fu T, Hammje K, Chen L, Hoang-Vu C. Role of CD97 isoforms in gastric carcinoma. Int J Oncol. 2010 Jun;36(6):1401-8. PubMed PMID: 20428763.

Yang J, Liu X, Zhao Y, Adamian M, Pawlyk B, Sun X, McMillan DR, Liberman MC, Li T. Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss. PLoS Genet. 2010 May 20;6(5):e1000955. PubMed PMID: 20502675.

Hoek RM, de Launay D, Kop EN, Yilmaz-Elis AS, Lin F, Reedquist KA, Verbeek JS, Medof ME, Tak PP, Hamann J. Deletion of either CD55 or CD97 ameliorates arthritis in mouse models. Arthritis Rheum. 2010 Apr;62(4):1036-42. PubMed PMID: 20131275.

van Eijk M, Aust G, Brouwer MS, van Meurs M, Voerman JS, Dijke IE, Pouwels W, Sändig I, Wandel E, Aerts JM, Boot RG, Laman JD, Hamann J. Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease. Immunol Lett. 2010 Apr 8;129(2):64-71. PubMed PMID: 20167235.

Deyev IE, Petrenko AG. Regulation of CIRL-1 proteolysis and trafficking. Biochimie. 2010 Apr;92(4):418-22. PubMed PMID: 20100540.

Xu L, Begum S, Barry M, Crowley D, Yang L, Bronson RT, Hynes RO. GPR56 plays varying roles in endogenous cancer progression. Clin Exp Metastasis. 2010 Apr;27(4):241-9. PubMed PMID: 20333450.

Ho YH, Lien MT, Lin CM, Wei SY, Chang LH, Hsu JC. Echinoid regulates Flamingo endocytosis to control ommatidial rotation in the Drosophila eye. Development. 2010 Mar;137(5):745-54. PubMed PMID: 20110316.

Della Chiesa M, Falco M, Parolini S, Bellora F, Petretto A, Romeo E, Balsamo M, Gambarotti M, Scordamaglia F, Tabellini G, Facchetti F, Vermi W, Bottino C, Moretta A, Vitale M. GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues. Int Immunol. 2010 Feb;22(2):91-100. PubMed PMID: 20008459.

Vallon M, Rohde F, Janssen KP, Essler M. Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation. Exp Cell Res. 2010 Feb 1;316(3):412-21. PubMed PMID: 19853600.

Fukushima A, Ishida W, Ojima A, Kajisako M, Sumi T, Yamada J, Tsuru E, Miyazaki J, Tominaga A, Yagita H. Participation of CD11b and F4/80 molecules in the conjunctival eosinophilia of experimental allergic conjunctivitis. Int Arch Allergy Immunol. 2010;151(2):129-36. PubMed PMID: 19752566.

Becker S, Wandel E, Wobus M, Schneider R, Amasheh S, Sittig D, Kerner C, Naumann R, Hamann J, Aust G. Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions. PLoS One. 2010 Jan 13;5(1):e8507. PubMed PMID: 20084281.

Kausar T, Sharma R, Hasan MR, Tripathi SC, Saraya A, Chattopadhyay TK, Gupta SD, Ralhan R. Clinical significance of GPR56, transglutaminase 2, and NF-κB in esophageal squamous cell carcinoma. Cancer Invest. 2011 Jan;29(1):42-8. PubMed PMID: 20874003.


Borgatti R, Marelli S, Bernardini L, Novelli A, Cavallini A, Tonelli A, Bassi MT, Dallapiccola B. Bilateral frontoparietal polymicrogyria (BFPP) syndrome secondary to a 16q12.1-q21 chromosome deletion involving GPR56 gene. Clin Genet. 2009 Dec;76(6):573-6. PubMed PMID: 19807741.

Langenhan T, Prömel S, Mestek L, Esmaeili B, Waller-Evans H, Hennig C, Kohara Y, Avery L, Vakonakis I, Schnabel R, Russ AP. Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. Dev Cell. 2009 Oct;17(4):494-504. PubMed PMID: 19853563.

Hsiao CC, Cheng KF, Chen HY, Chou YH, Stacey M, Chang GW, Lin HH. Site-specific N-glycosylation regulates the GPS auto-proteolysis of CD97. FEBS Lett. 2009 Oct 6;583(19):3285-90. PubMed PMID: 19737555.

de Groot DM, Vogel G, Dulos J, Teeuwen L, Stebbins K, Hamann J, Owens BM, van Eenennaam H, Bos E, Boots AM. Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2. J Immunol. 2009 Sep 15;183(6):4127-34. PubMed PMID: 19717518.

Monk KR, Naylor SG, Glenn TD, Mercurio S, Perlin JR, Dominguez C, Moens CB, Talbot WS. A G protein-coupled receptor is essential for Schwann cells to initiate myelination. Science. 2009 Sep 11;325(5946):1402-5. PubMed PMID: 19745155.

Yagi H, Noguchi Y, Kitamura K, Sato M. Deficiency of Vlgr1 resulted in deafness and susceptibility to audiogenic seizures while the degree of hearing impairment was not correlated with seizure severity in C57BL/6- and 129-backcrossed lines of Vlgr1 knockout mice. Neurosci Lett. 2009 Sep 18;461(2):190-5. PubMed PMID: 19539720.

Nakamura M, Hamada M, Hasegawa K, Kusakabe M, Suzuki H, Greaves DR, Moriguchi T, Kudo T, Takahashi S. c-Maf is essential for the F4/80 expression in macrophages in vivo. Gene. 2009 Sep 15;445(1-2):66-72. PubMed PMID: 19539733.

Zhang GJ, Chen TB, Connolly B, Lin SA, Hargreaves R, Vanko A, Bednar B, Macneil DJ, Sur C, Williams DL. In vivo optical imaging of LacZ expression using lacZ transgenic mice. Assay Drug Dev Technol. 2009 Aug;7(4):391-9. PubMed PMID: 19689207.

Bai Y, Du L, Shen L, Zhang Y, Zhang L. GPR56 is highly expressed in neural stem cells but downregulated during differentiation. Neuroreport. 2009 Jul 1;20(10):918-22. PubMed PMID: 19525879.

Parrini E, Ferrari AR, Dorn T, Walsh CA, Guerrini R. Bilateral frontoparietal polymicrogyria, Lennox-Gastaut syndrome, and GPR56 gene mutations. Epilepsia. 2009 Jun;50(6):1344-53. PubMed PMID: 19016831.

Koirala S, Jin Z, Piao X, Corfas G. GPR56-regulated granule cell adhesion is essential for rostral cerebellar development. J Neurosci. 2009 Jun 10;29(23):7439-49. PubMed PMID: 19515912.

Kop EN, Matmati M, Pouwels W, Leclercq G, Tak PP, Hamann J. Differential expression of CD97 on human lymphocyte subsets and limited effect of CD97 antibodies on allogeneic T-cell stimulation. Immunol Lett. 2009 Apr 27;123(2):160-8. PubMed PMID: 19428565.

Hilgert N, Kahrizi K, Dieltjens N, Bazazzadegan N, Najmabadi H, Smith RJ, Van Camp G. A large deletion in GPR98 causes type IIC Usher syndrome in male and female members of an Iranian family. J Med Genet. 2009 Apr;46(4):272-6. PubMed PMID: 19357116.

Krasnoperov V, Deyev IE, Serova OV, Xu C, Lu Y, Buryanovsky L, Gabibov AG, Neubert TA, Petrenko AG. Dissociation of the subunits of the calcium-independent receptor of alpha-latrotoxin as a result of two-step proteolysis. Biochemistry. 2009 Apr 14;48(14):3230-8. PubMed PMID: 19161337.

Steinel MC, Whitington PM. The atypical cadherin Flamingo is required for sensory axon advance beyond intermediate target cells. Dev Biol. 2009 Mar 15;327(2):447-57. PubMed PMID: 19146847.

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Carreira-Barbosa F, Kajita M, Morel V, Wada H, Okamoto H, Martinez Arias A, Fujita Y, Wilson SW, Tada M. Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation. Development. 2009 Feb;136(3):383-92. PubMed PMID 19091770.

Kaur B, Cork SM, Sandberg EM, Devi NS, Zhang Z, Klenotic PA, Febbraio M, Shim H, Mao H, Tucker-Burden C, Silverstein RL, Brat DJ, Olson JJ, Van Meir EG. Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism. Cancer Res. 2009 Feb 1;69(3):1212-20. PubMed PMID: 19176395.

Hardcastle J, Kurozumi K, Dmitrieva N, Sayers MP, Ahmad S, Waterman P, Weissleder R, Chiocca EA, Kaur B. Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1. Mol Ther. 2010 Feb;18(2):285-94. PubMed PMID: 19844198.

Kim JE, Han JM, Park CR, Shin KJ, Ahn C, Seong JY, Hwang JI. Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis. J Cancer Res Clin Oncol. 2010 Jan;136(1):47-53. PubMed PMID: 19572147.


Veninga H, Becker S, Hoek RM, Wobus M, Wandel E, van der Kaa J, van der Valk M, de Vos AF, Haase H, Owens B, van der Poll T, van Lier RA, Verbeek JS, Aust G, Hamann J. Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration. J Immunol. 2008 Nov 1;181(9):6574-83. PubMed PMID: 18941248.

Pickering C, Hägglund M, Szmydynger-Chodobska J, Marques F, Palha JA, Waller L, Chodobski A, Fredriksson R, Lagerström MC, Schiöth HB. The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury. BMC Neurosci. 2008 Oct 3;9:97. PubMed PMID: 18834514.

Strutt H, Strutt D. Differential stability of flamingo protein complexes underlies the establishment of planar polarity. Curr Biol. 2008 Oct 28;18(20):1555-64. PubMed PMID.

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van Pel M, Hagoort H, Hamann J, Fibbe WE. CD97 is differentially expressed on murine hematopoietic stem-and progenitor-cells. Haematologica. 2008 Aug;93(8):1137-44. PubMed PMID: 18603564.

Kirchhoff C, Osterhoff C, Samalecos A. HE6/GPR64 adhesion receptor co-localizes with apical and subapical F-actin scaffold in male excurrent duct epithelia. Reproduction. 2008 Aug;136(2):235-45. PubMed PMID: 18469038.

Vakonakis I, Langenhan T, Prömel S, Russ A, Campbell ID. Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain. Structure. 2008 Jun;16(6):944-53. PubMed PMID: 18547526.

Chen WS, Antic D, Matis M, Logan CY, Povelones M, Anderson GA, Nusse R, Axelrod JD. Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell. 2008 Jun 13;133(6):1093-105. PubMed PMID: 18555784.

Iguchi T, Sakata K, Yoshizaki K, Tago K, Mizuno N, Itoh H. Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12/13 and Rho pathway. J Biol Chem. 2008 May 23;283(21):14469-78. PubMed PMID: 18378689.

Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G, Piao X.GPR56 regulates pial basement membrane integrity and cortical lamination. JNeurosci. 2008 May 28;28(22):5817-26. PubMed PMID: 18509043.

Wobus M, Wandel E, Prohaska S, Findeiss S, Tschöp K, Aust G. Transcriptional regulation of the human CD97 promoter by Sp1/Sp3 in smooth muscle cells. Gene. 2008 Apr 30;413(1-2):67-75. PubMed PMID: 18329191.

van Pel M, Hagoort H, Kwakkenbos MJ, Hamann J, Fibbe WE. Differential role of CD97 in interleukin-8-induced and granulocyte-colony stimulating factor-induced hematopoietic stem and progenitor cell mobilization. Haematologica. 2008 Apr;93(4):601-4. PubMed PMID: 18326527.

Lagerström MC, Schiöth HB. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov. 2008 Apr;7(4):339-57. Review. PubMed PMID: 18382464.

Haitina T, Olsson F, Stephansson O, Alsiö J, Roman E, Ebendal T, Schiöth HB, Fredriksson R. Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat. BMC Neurosci. 2008 Apr 29;9:43. PubMed PMID: 18445277.

Chen PL, Clandinin TR. The cadherin Flamingo mediates level-dependent interactions that guide photoreceptor target choice in Drosophila. Neuron. 2008 Apr 10;58(1):26-33. PubMed PMID: 18400160.

Chiu PL, Ng BH, Chang GW, Gordon S, Lin HH. Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors. FEBS Lett. 2008 Mar 5;582(5):792-8. PubMed PMID: 18267122.

Yona S, Lin HH, Dri P, Davies JQ, Hayhoe RP, Lewis SM, Heinsbroek SE, Brown KA, Perretti M, Hamann J, Treacher DF, Gordon S, Stacey M. Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. FASEB J. 2008 Mar;22(3):741-51. PubMed PMID: 17928360.

Ke N, Ma H, Diedrich G, Chionis J, Liu G, Yu DH, Wong-Staal F, Li QX. Biochemical characterization of genetic mutations of GPR56 in patients with bilateral frontoparietal polymicrogyria (BFPP). Biochem Biophys Res Commun. 2008 Feb 8;366(2):314-20. PubMed PMID: 18042463.

Maerker T, van Wijk E, Overlack N, Kersten FF, McGee J, Goldmann T, Sehn E, Roepman R, Walsh EJ, Kremer H, Wolfrum U. A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cells. Hum Mol Genet. 2008 Jan 1;17(1):71-86. PubMed PMID: 17906286.

Nordström KJ, Fredriksson R, Schiöth HB. The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors. BMC Evol Biol. 2008 Jan 16;8:9. PubMed PMID: 18199322.

Seandel M, Falciatori I, Shmelkov SV, Kim J, James D, Rafii S. Niche players: spermatogonial progenitors marked by GPR125. Cell Cycle. 2008 Jan 15;7(2):135-40. Epub 2007 Nov 1. PubMed PMID: 18256534.


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Park D, Tosello-Trampont AC, Elliott MR, Lu M, Haney LB, Ma Z, Klibanov AL, Mandell JW, Ravichandran KS. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature. 2007 Nov 15;450(7168):430-4. PubMed PMID: 17960134.

Kudo S, Konda R, Obara W, Kudo D, Tani K, Nakamura Y, Fujioka T. Inhibition of tumor growth through suppression of angiogenesis by brain-specific angiogenesis inhibitor 1 gene transfer in murine renal cell carcinoma. Oncol Rep. 2007 Oct;18(4):785-91. PubMed PMID: 17786337.

Hamann J, Koning N, Pouwels W, Ulfman LH, van Eijk M, Stacey M, Lin HH, Gordon S, Kwakkenbos MJ. EMR1, the human homolog of F4/80, is an eosinophil-specific receptor. Eur J Immunol. 2007 Oct;37(10):2797-802. PubMed PMID: 17823986.

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Jin Z, Tietjen I, Bu L, Liu-Yesucevitz L, Gaur SK, Walsh CA, Piao X. Disease-associated mutations affect GPR56 protein trafficking and cell surface expression. Hum Mol Genet. 2007 Aug 15;16(16):1972-85. PubMed PMID: 17576745.

Abbott RJ, Spendlove I, Roversi P, Fitzgibbon H, Knott V, Teriete P, McDonnell JM, Handford PA, Lea SM. Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55. J Biol Chem. 2007 Jul 27;282(30):22023-32. PubMed PMID: 17449467.

Davies JQ, Chang GW, Yona S, Gordon S, Stacey M, Lin HH. The role of receptor oligomerization in modulating the expression and function of leukocyte adhesion-G protein-coupled receptors. J Biol Chem. 2007 Sep 14;282(37):27343-53. PubMed PMID: 17620333.

Michalski N, Michel V, Bahloul A, Lefevre G, Barral J, Yagi H, Chardenoux S, Weil D, Martin P, Hardelin JP, Sato M, Petit C. Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci. 2007 Jun 13;27(24):6478-88. PubMed PMID: 17567809.

Ke N, Sundaram R, Liu G, Chionis J, Fan W, Rogers C, Awad T, Grifman M, Yu D, Wong-Staal F, Li QX. Orphan G protein-coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathway. Mol Cancer Ther. 2007 Jun;6(6):1840-50. PubMed PMID: 17575113.

Davies B, Behnen M, Cappallo-Obermann H, Spiess AN, Theuring F, Kirchhoff C. Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor gene disruption. Mol Reprod Dev. 2007 May;74(5):539-53. PubMed PMID: 17034053.

Bao H, Berlanga ML, Xue M, Hapip SM, Daniels RW, Mendenhall JM, Alcantara AA, Zhang B. The atypical cadherin flamingo regulates synaptogenesis and helps prevent axonal and synaptic degeneration in Drosophila. Mol Cell Neurosci. 2007 Apr;34(4):662-78. PubMed PMID: 17321750.

Wasserscheid I, Thomas U, Knust E. Isoform-specific interaction of Flamingo/Starry Night with excess Bazooka affects planar cell polarity in the Drosophila wing. Dev Dyn. 2007 Apr;236(4):1064-71. PubMed PMID: 17304516.

Wang T, Tian L, Haino M, Gao JL, Lake R, Ward Y, Wang H, Siebenlist U, Murphy PM, Kelly K. Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97. Infect Immun. 2007 Mar;75(3):1144-53. PubMed PMID: 17158902.

Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J. The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. J Leukoc Biol. 2007 Feb;81(2):440-8. PubMed PMID: 17108056.

Yagi H, Tokano H, Maeda M, Takabayashi T, Nagano T, Kiyama H, Fujieda S, Kitamura K, Sato M. Vlgr1 is required for proper stereocilia maturation of cochlear hair cells. Genes Cells. 2007 Feb;12(2):235-50. PubMed PMID: 17295842.

Lagerström MC, Rabe N, Haitina T, Kalnina I, Hellström AR, Klovins J, Kullander K, Schiöth HB. The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal cells. J Neurochem. 2007 Feb;100(4):1129-42. PubMed PMID: 17212699.

Chang GW, Davies JQ, Stacey M, Yona S, Bowdish DM, Hamann J, Chen TC, Lin CY, Gordon S, Lin HH. CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells. Biochem Biophys Res Commun. 2007 Feb 2;353(1):133-8. PubMed PMID: 17174274.

Strutt D, Strutt H. Differential activities of the core planar polarity proteins during Drosophila wing patterning. Dev Biol. 2007 Feb 1;302(1):181-94. PubMed PMID: 17045581.

Bjarnadóttir TK, Geirardsdóttir K, Ingemansson M, Mirza MA, Fredriksson R, Schiöth HB. Identification of novel splice variants of Adhesion G protein-coupled receptors. Gene. 2007 Jan 31;387(1-2):38-48. PubMed PMID: 17056209.

Huang Y, Fan J, Yang J, Zhu GZ. Characterization of GPR56 protein and its suppressed expression in human pancreatic cancer cells. Mol Cell Biochem. 2008 Jan;308(1-2):133-9. PubMed PMID: 17932623.

Xu L, Hynes RO. GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 2007 Jan 15;6(2):160-5. Review. PubMed PMID: 17314516.


Doyle SE, Scholz MJ, Greer KA, Hubbard AD, Darnell DK, Antin PB, Klewer SE, Runyan RB. Latrophilin-2 is a novel component of the epithelial-mesenchymal transition within the atrioventricular canal of the embryonic chicken heart. Dev Dyn. 2006 Dec;235(12):3213-21. PubMed PMID: 17016846.

Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J. An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2. FASEB J. 2006 Dec;20(14):2582-4. PubMed PMID: 17068111.

Vallon M, Essler M. Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans. J Biol Chem. 2006 Nov 10;281(45):34179-88. PubMed PMID: 16982628.

Galle J, Sittig D, Hanisch I, Wobus M, Wandel E, Loeffler M, Aust G. Individual cell-based models of tumor-environment interactions: Multiple effects of CD97 on tumor invasion. Am J Pathol. 2006 Nov;169(5):1802-11. PubMed PMID: 17071601.

Wobus M, Huber O, Hamann J, Aust G. CD97 overexpression in tumor cells at the invasion front in colorectal cancer (CC) is independently regulated of the canonical Wnt pathway. Mol Carcinog. 2006 Nov;45(11):881-6. PubMed PMID: 16929497.

Casal J, Lawrence PA, Struhl G. Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. Development. 2006 Nov;133(22):4561-72. PubMed PMID: 17075008.

Fukuzawa T, Hirose S. Multiple processing of Ig-Hepta/GPR116, a G protein-coupled receptor with immunoglobulin (Ig)-like repeats, and generation of EGF2-like fragment. J Biochem. 2006 Sep;140(3):445-52. PubMedPMID: 16882675.

Moriguchi T, Hamada M, Morito N, Terunuma T, Hasegawa K, Zhang C, Yokomizo T, Esaki R, Kuroda E, Yoh K, Kudo T, Nagata M, Greaves DR, Engel JD, Yamamoto M, Takahashi S. MafB is essential for renal development and F4/80 expression in macrophages. Mol Cell Biol. 2006 Aug;26(15):5715-27. PubMed PMID: 16847325.

Capasso M, Durrant LG, Stacey M, Gordon S, Ramage J, Spendlove I. Costimulation via CD55 on human CD4+ T cells mediated by CD97. J Immunol. 2006 Jul 15;177(2):1070-7. PubMed PMID: 16818763.

Xu L, Begum S, Hearn JD, Hynes RO. GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9023-8. PubMed PMID: 16757564.

McGee J, Goodyear RJ, McMillan DR, Stauffer EA, Holt JR, Locke KG, Birch DG, Legan PK, White PC, Walsh EJ, Richardson GP. The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles. J Neurosci. 2006 Jun 14;26(24):6543-53. PubMed PMID: 16775142.

Lagerström MC, Hellström AR, Gloriam DE, Larsson TP, Schiöth HB, Fredriksson R. The G protein-coupled receptor subset of the chicken genome. PLoS Comput Biol. 2006 Jun 2;2(6):e54. PubMed PMID: 16741557.

Gottwald U, Davies B, Fritsch M, Habenicht UF. New approaches for male fertility control: HE6 as an example of a putative target. Mol Cell Endocrinol. 2006 May 16;250(1-2):49-57. PubMed PMID: 16442214.

Kirchhoff C, Obermann H, Behnen M, Davies B. Role of epididymal receptor HE6 in the regulation of sperm microenvironment. Mol Cell Endocrinol. 2006 May 16;250(1-2):43-8. PubMed PMID: 16413110.

Kop EN, Adriaansen J, Smeets TJ, Vervoordeldonk MJ, van Lier RA, Hamann J, Tak PP. CD97 neutralisation increases resistance to collagen-induced arthritis in mice. Arthritis Res Ther. 2006;8(5):R155. PubMed PMID: 17007638.

Aust G, Wandel E, Boltze C, Sittig D, Schütz A, Horn LC, Wobus M. Diversity of CD97 in smooth muscle cells. Cell Tissue Res. 2006 Apr;324(1):139-47. PubMed PMID: 16408199.

Kang X, Xiao X, Harata M, Bai Y, Nakazaki Y, Soda Y, Kurita R, Tanaka T, Komine F, Izawa K, Kunisaki R, Setoyama M, Nishimori H, Natsume A, Sunamura M, Lozonshi L, Saitoh I, Tokino T, Asano S, Nakamura Y, Tani K. Antiangiogenic activity of BAI1 in vivo: implications for gene therapy of human glioblastomas. Cancer Gene Ther. 2006 Apr;13(4):385-92. PubMed PMID: 16244591.

van Wijk E, van der Zwaag B, Peters T, Zimmermann U, Te Brinke H, Kersten FF, Märker T, Aller E, Hoefsloot LH, Cremers CW, Cremers FP, Wolfrum U, Knipper M, Roepman R, Kremer H. The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1. Hum Mol Genet. 2006 Mar 1;15(5):751-65. PubMed PMID: 16434480.

Lajus S, Vacher P, Huber D, Dubois M, Benassy MN, Ushkaryov Y, Lang J. Alpha-latrotoxin induces exocytosis by inhibition of voltage-dependent K+ channels and by stimulation of L-type Ca2+ channels via latrophilin in beta-cells. J Biol Chem. 2006 Mar 3;281(9):5522-31. PubMed PMID: 16301314.

Kimura H, Usui T, Tsubouchi A, Uemura T. Potential dual molecular interaction of the Drosophila 7-pass transmembrane cadherin Flamingo in dendritic morphogenesis. J Cell Sci. 2006 Mar 15;119(Pt 6):1118-29. PubMed PMID: 16507587.

Sud N, Sharma R, Ray R, Chattopadhyay TK, Ralhan R. Differential expression of G-protein coupled receptor 56 in human esophageal squamous cell carcinoma. Cancer Lett. 2006 Feb 28;233(2):265-70. PubMed PMID: 15916848.

Tissir F, Goffinet AM. Expression of planar cell polarity genes during development of the mouse CNS. Eur J Neurosci. 2006 Feb;23(3):597-607. PubMed PMID: 16487141.

Caminschi I, Vandenabeele S, Sofi M, McKnight AJ, Ward N, Brodnicki TC, Toy T, Lahoud M, Maraskovsky E, Shortman K, Wright MD. Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE. DNA Seq. 2006 Feb;17(1):8-14. PubMed PMID: 16753812.

Jeong BC, Kim MY, Lee JH, Kee HJ, Kho DH, Han KE, Qian YR, Kim JK, Kim KK. Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. FEBS Lett. 2006 Jan 23;580(2):669-76. PubMed PMID: 16412436.


Liu Y, Chen L, Peng S, Chen Z, Gimm O, Finke R, Hoang-Vu C. The expression of CD97EGF and its ligand CD55 on marginal epithelium is related to higher stage and depth of tumor invasion of gastric carcinomas. Oncol Rep. 2005 Dec;14(6):1413-20. PubMed PMID: 16273233.

Piao X, Chang BS, Bodell A, Woods K, Benzeev B, Topcu M, Guerrini R, Goldberg-Stern H, Sztriha L, Dobyns WB, Barkovich AJ, Walsh CA. Genotype-phenotype analysis of human frontoparietal polymicrogyria syndromes. Ann Neurol. 2005 Nov;58(5):680-7. PubMed PMID: 16240336.

van den Berg TK, Kraal G. A function for the macrophage F4/80 molecule in tolerance induction. Trends Immunol. 2005 Oct;26(10):506-9. Review. PubMed PMID: 16087400.

Gasz B, Lenard L, Benko L, Borsiczky B, Szanto Z, Lantos J, Szabados S, Alotti N, Papp L, Roth E. Expression of CD97 and adhesion molecules on circulating leukocytes in patients undergoing coronary artery bypass surgery. Eur Surg Res. 2005 Sep-Oct;37(5):281-9. PubMed PMID: 16374010.

Beall SA, Boekelheide K, Johnson KJ. Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity. J Androl. 2005 Jul-Aug;26(4):529-38. PubMed PMID: 15955893.

Gibert Y, McMillan DR, Kayes-Wandover K, Meyer A, Begemann G, White PC. Analysis of the very large G-protein coupled receptor gene (Vlgr1/Mass1/USH2C) in zebrafish. Gene. 2005 Jul 4;353(2):200-6. PubMed PMID: 15979825.

Davies A, Formstone C, Mason I, Lewis J. Planar polarity of hair cells in the chick inner ear is correlated with polarized distribution of c-flamingo-1 protein. Dev Dyn. 2005 Jul;233(3):998-1005. PubMed PMID: 15830377.

Formstone CJ, Mason I. Combinatorial activity of Flamingo proteins directs convergence and extension within the early zebrafish embryo via the planar cell polarity pathway. Dev Biol. 2005 Jun 15;282(2):320-35. PubMed PMID: 15882862.

Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, Kerley M, Mucenski ML, Gordon S, Stein-Streilein J. The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med. 2005 May 16;201(10):1615-25. PubMed PMID: 15883173.

Schiöth HB, Fredriksson R. The GRAFS classification system of G-protein coupled receptors in comparative perspective. Gen Comp Endocrinol. 2005 May 15;142(1-2):94-101. Review. PubMed PMID: 15862553.

Fredriksson R, Schiöth HB. The repertoire of G-protein-coupled receptors in fully sequenced genomes. Mol Pharmacol. 2005 May;67(5):1414-25. PubMed PMID: 15687224.

Kaur B, Brat DJ, Devi NS, Van Meir EG. Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor. Oncogene. 2005 May 19;24(22):3632-42. PubMed PMID: 15782143.

Yoon KC, Ahn KY, Lee JH, Chun BJ, Park SW, Seo MS, Park YG, Kim KK. Lipid-mediated delivery of brain-specific angiogenesis inhibitor 1 gene reduces corneal neovascularization in an in vivo rabbit model. Gene Ther. 2005 Apr;12(7):617-24. PubMed PMID: 15703766.

LopezJimenez ND, Sainz E, Cavenagh MM, Cruz-Ithier MA, Blackwood CA, Battey JF, Sullivan SL. Two novel genes, Gpr113, which encodes a family 2 G-protein-coupled receptor, and Trcg1, are selectively expressed in taste receptor cells. Genomics. 2005 Apr;85(4):472-82. PubMed PMID: 15780750.

Tissir F, Bar I, Jossin Y, De Backer O, Goffinet AM. Protocadherin Celsr3 is crucial in axonal tract development. Nat Neurosci. 2005 Apr;8(4):451-7. PubMed PMID: 15778712.

Wang T, Ward Y, Tian L, Lake R, Guedez L, Stetler-Stevenson WG, Kelly K. CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells. Blood. 2005 Apr 1;105(7):2836-44. PubMed PMID: 15576472.

Shashidhar S, Lorente G, Nagavarapu U, Nelson A, Kuo J, Cummins J, Nikolich K, Urfer R, Foehr ED. GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion. Oncogene. 2005 Mar 3;24(10):1673-82. PubMed PMID: 15674329.

Kop EN, Kwakkenbos MJ, Teske GJ, Kraan MC, Smeets TJ, Stacey M, Lin HH, Tak PP, Hamann J. Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissue. Arthritis Rheum. 2005 Feb;52(2):442-50. PubMed PMID: 15693006.

Schwartz SB, Aleman TS, Cideciyan AV, Windsor EA, Sumaroka A, Roman AJ, Rane T, Smilko EE, Bennett J, Stone EM, Kimberling WJ, Liu XZ, Jacobson SG. Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype. Invest Ophthalmol Vis Sci. 2005 Feb;46(2):734-43. PubMed PMID: 15671307.

Formstone CJ, Mason I. Expression of the Celsr/flamingo homologue, c-fmi1, in the early avian embryo indicates a conserved role in neural tube closure and additional roles in asymmetry and somitogenesis. Dev Dyn. 2005 Feb;232(2):408-13. PubMed PMID: 15614764.

Kwakkenbos MJ, Pouwels W, Matmati M, Stacey M, Lin HH, Gordon S, van Lier RA, Hamann J. Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells. J Leukoc Biol. 2005 Jan;77(1):112-9. PubMed PMID: 15498814.

Mustafa T, Eckert A, Klonisch T, Kehlen A, Maurer P, Klintschar M, Erhuma M, Zschoyan R, Gimm O, Dralle H, Schubert J, Hoang-Vu C. Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas. Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):108-19. PubMed PMID: 15668483.

Yagi H, Takamura Y, Yoneda T, Konno D, Akagi Y, Yoshida K, Sato M. Vlgr1 knockout mice show audiogenic seizure susceptibility. J Neurochem. 2005 Jan;92(1):191-202. PubMed PMID: 15606908.


Hamann J. The EGF-TM7 family of the rat. Immunogenetics. 2004 Dec;56(9):679-81. PubMed PMID: 15578266.

O’Reilly D, Addley M, Quinn C, MacFarlane AJ, Gordon S, McKnight AJ, Greaves DR. Functional analysis of the murine Emr1 promoter identifies a novel purine-rich regulatory motif required for high-level gene expression in macrophages. Genomics. 2004 Dec;84(6):1030-40. PubMed PMID: 15533720.

Wobus M, Vogel B, Schmücking E, Hamann J, Aust G. N-glycosylation of CD97 within the EGF domains is crucial for epitope accessibility in normal and malignant cells as well as CD55 ligand binding. Int J Cancer. 2004 Dec 10;112(5):815-22. PubMed PMID: 15386373.

Volynski KE, Silva JP, Lelianova VG, Atiqur Rahman M, Hopkins C, Ushkaryov YA. Latrophilin fragments behave as independent proteins that associate and signal on binding of LTX(N4C). EMBO J. 2004 Nov 10;23(22):4423-33. PubMed PMID: 15483624.

Davies B, Baumann C, Kirchhoff C, Ivell R, Nubbemeyer R, Habenicht UF, Theuring F, Gottwald U. Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility. Mol Cell Biol. 2004 Oct;24(19):8642-8. PubMed PMID: 15367682.

Willson J, Amliwala K, Davis A, Cook A, Cuttle MF, Kriek N, Hopper NA, O’Connor V, Harder A, Walker RJ, Holden-Dye L. Latrotoxin receptor signaling engages the UNC-13-dependent vesicle-priming pathway in C. elegans. Curr Biol. 2004 Aug 10;14(15):1374-9. PubMed PMID: 15296755.

Lin HH, Chang GW, Davies JQ, Stacey M, Harris J, Gordon S. Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif. J Biol Chem. 2004 Jul 23;279(30):31823-32. PubMed PMID: 15150276.

Stehlik C, Kroismayr R, Dorfleutner A, Binder BR, Lipp J. VIGR–a novel inducible adhesion family G-protein coupled receptor in endothelial cells. FEBS Lett. 2004 Jul 2;569(1-3):149-55. PubMed PMID: 15225624.

Eichler W, Stieler JT, Vogel B, Wobus M, Aust G. Molecular cloning of bovine CD97: an EGF-TM7 molecule expressed as isoforms. Mol Immunol. 2004 Jul;41(8):751-8. PubMed PMID: 15234554.

Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics. 2004 Jul;84(1):23-33. PubMed PMID: 15203201.

Kee HJ, Ahn KY, Choi KC, Won Song J, Heo T, Jung S, Kim JK, Bae CS, Kim KK. Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma. FEBS Lett. 2004 Jul 2;569(1-3):307-16. PubMed PMID: 15225653.

McMillan DR, White PC. Loss of the transmembrane and cytoplasmic domains of the very large G-protein-coupled receptor-1 (VLGR1 or Mass1) causes audiogenic seizures in mice. Mol Cell Neurosci. 2004 Jun;26(2):322-9. PubMed PMID: 15207856.

Moriguchi T, Haraguchi K, Ueda N, Okada M, Furuya T, Akiyama T. DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites. Genes Cells. 2004 Jun;9(6):549-60. PubMed PMID: 15189448.

Kim MY, Ahn KY, Lee SM, Koh JT, Chun BJ, Bae CS, Lee KS, Kim KK. The promoter of brain-specific angiogenesis inhibitor 1-associated protein 4 drives developmentally targeted transgene expression mainly in adult cerebral cortex and hippocampus. FEBS Lett. 2004 May 21;566(1-3):87-94. PubMed PMID: 15147874.

Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. Oncogene. 2004 May 13;23(22):3889-97. PubMed PMID: 15021905.

Abbott RJ, Knott V, Roversi P, Neudeck S, Lukacik P, Handford PA, Lea SM. Crystallization and preliminary X-ray diffraction analysis of three EGF domains of EMR2, a 7TM immune-system molecule. Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):936-8. PubMed PMID: 15103144.

Little KD, Hemler ME, Stipp CS. Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association. Mol Biol Cell. 2004 May;15(5):2375-87. PubMed PMID: 15004227.

Nam DH, Park K, Suh YL, Kim JH. Expression of VEGF and brain specific angiogenesis inhibitor-1 in glioblastoma: prognostic significance. Oncol Rep. 2004 Apr;11(4):863-9. PubMed PMID: 15010886.

Piao X, Hill RS, Bodell A, Chang BS, Basel-Vanagaite L, Straussberg R, Dobyns WB, Qasrawi B, Winter RM, Innes AM, Voit T, Ross ME, Michaud JL, Déscarie JC, Barkovich AJ, Walsh CA. G protein-coupled receptor-dependent development of human frontal cortex. Science. 2004 Mar 26;303(5666):2033-6. PubMed PMID: 15044805.

Koh JT, Kook H, Kee HJ, Seo YW, Jeong BC, Lee JH, Kim MY, Yoon KC, Jung S, Kim KK. Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin. Exp Cell Res. 2004 Mar 10;294(1):172-84. PubMed PMID: 14980512.

Weston MD, Luijendijk MW, Humphrey KD, Möller C, Kimberling WJ. Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II. Am J Hum Genet. 2004 Feb;74(2):357-66. PubMed PMID: 14740321.

Mustafa T, Klonisch T, Hombach-Klonisch S, Kehlen A, Schmutzler C, Koehrle J, Gimm O, Dralle H, Hoang-Vu C. Expression of CD97 and CD55 in human medullary thyroid carcinomas. Int J Oncol. 2004 Feb;24(2):285-94. PubMed PMID: 14719104.

Mee CJ, Tomlinson SR, Perestenko PV, De Pomerai D, Duce IR, Usherwood PN, Bell DR. Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegans. Biochem J. 2004 Feb 15;378(Pt 1):185-91. PubMed PMID: 14594448.

Leemans JC, te Velde AA, Florquin S, Bennink RJ, de Bruin K, van Lier RA, van der Poll T, Hamann J. The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense. J Immunol. 2004 Jan 15;172(2):1125-31. PubMed PMID: 14707087.


Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J. The EGF-TM7 family: a postgenomic view. Immunogenetics. 2004 Jan;55(10):655-66. Review. PubMed PMID: 14647991.

Chang GW, Stacey M, Kwakkenbos MJ, Hamann J, Gordon S, Lin HH. Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif. FEBS Lett. 2003 Jul 17;547(1-3):145-50. PubMed PMID: 12860403.

Stacey M, Chang GW, Davies JQ, Kwakkenbos MJ, Sanderson RD, Hamann J, Gordon S, Lin HH. The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. Blood. 2003 Oct 15;102(8):2916-24. PubMed PMID: 12829604.

Curtin JA, Quint E, Tsipouri V, Arkell RM, Cattanach B, Copp AJ, Henderson DJ, Spurr N, Stanier P, Fisher EM, Nolan PM, Steel KP, Brown SD, Gray IC, Murdoch JN. Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol. 2003 Jul 1;13(13):1129-33. PubMed PMID: 12842012.

Aust G, Hamann J, Schilling N, Wobus M. Detection of alternatively spliced EMR2 mRNAs in colorectal tumor cell lines but rare expression of the molecule in colorectal adenocarcinomas. Virchows Arch. 2003 Jul;443(1):32-7. PubMed PMID: 12761622.

de la Lastra JM, Shahein YE, Garrido JJ, Llanes D. Molecular cloning and structural analysis of the porcine homologue to CD97 antigen. Vet Immunol Immunopathol. 2003 Jun 20;93(3-4):107-15. PubMed PMID: 12814696.

Lee RC, Clandinin TR, Lee CH, Chen PL, Meinertzhagen IA, Zipursky SL. The protocadherin Flamingo is required for axon target selection in the Drosophila visual system. Nat Neurosci. 2003 Jun;6(6):557-63. PubMed PMID: 12754514.

Morgan R, El-Kadi AM, Theokli C. Flamingo, a cadherin-type receptor involved in the Drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in Xenopus laevis. Int J Dev Biol. 2003 May;47(4):245-52. PubMed PMID: 12755329.

Senti KA, Usui T, Boucke K, Greber U, Uemura T, Dickson BJ. Flamingo regulates R8 axon-axon and axon-target interactions in the Drosophila visual system. Curr Biol. 2003 May 13;13(10):828-32. PubMed PMID: 12747830.

Rawls AS, Wolff T. Strabismus requires Flamingo and Prickle function to regulate tissue polarity in the Drosophila eye. Development. 2003 May;130(9):1877-87. PubMed PMID: 12642492.

Hamann J, Kwakkenbos MJ, de Jong EC, Heus H, Olsen AS, van Lier RA. Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence. Eur J Immunol. 2003 May;33(5):1365-71. PubMed PMID: 12731063.

Reuter JE, Nardine TM, Penton A, Billuart P, Scott EK, Usui T, Uemura T, Luo L. A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesis. Development. 2003 Mar;130(6):1203-13. PubMed PMID: 12571111.

Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem Biophys Res Commun. 2003 Feb 14;301(3):725-34. PubMed PMID: 12565841.

Obermann H, Samalecos A, Osterhoff C, Schröder B, Heller R, Kirchhoff C. HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. Mol Reprod Dev. 2003 Jan;64(1):13-26. PubMed PMID: 12420295.

Kaur B, Brat DJ, Calkins CC, Van Meir EG. Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. Am J Pathol. 2003 Jan;162(1):19-27. PubMed PMID: 12507886; PubMed Central PMCID: PMC1851137.


Schaller E, Macfarlane AJ, Rupec RA, Gordon S, McKnight AJ, Pfeffer K. Inactivation of the F4/80 glycoprotein in the mouse germ line. Mol Cell Biol. 2002 Nov;22(22):8035-43. PubMed PMID: 12391169.

Aust G, Steinert M, Schütz A, Boltze C, Wahlbuhl M, Hamann J, Wobus M. CD97, but not its closely related EGF-TM7 family member EMR2, is expressed on gastric, pancreatic, and esophageal carcinomas. Am J Clin Pathol. 2002 Nov;118(5):699-707. PubMed PMID: 12428789.

Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett. 2002 Nov 20;531(3):407-14. PubMed PMID: 12435584.

Visser L, de Vos AF, Hamann J, Melief MJ, van Meurs M, van Lier RA, Laman JD, Hintzen RQ. Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis. J Neuroimmunol. 2002 Nov;132(1-2):156-63. PubMed PMID: 12417446.

Kee HJ, Koh JT, Kim MY, Ahn KY, Kim JK, Bae CS, Park SS, Kim KK. Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. J Cereb Blood Flow Metab. 2002 Sep;22(9):1054-67. PubMed PMID: 12218411.

Stacey M, Chang GW, Sanos SL, Chittenden LR, Stubbs L, Gordon S, Lin HH. EMR4, a novel epidermal growth factor (EGF)-TM7 molecule up-regulated in activated mouse macrophages, binds to a putative cellular ligand on B lymphoma cell line A20. J Biol Chem. 2002 Aug 9;277(32):29283-93. PubMed PMID: 12023293.

Kreienkamp HJ, Soltau M, Richter D, Böckers T. Interaction of G-protein-coupled receptors with synaptic scaffolding proteins. Biochem Soc Trans. 2002 Aug;30(4):464-8. Review. PubMed PMID: 12196116.

Scheel H, Tomiuk S, Hofmann K. A common protein interaction domain links two recently identified epilepsy genes. Hum Mol Genet. 2002 Jul 15;11(15):1757-62. PubMed PMID: 12095917.

Abe J, Fukuzawa T, Hirose S. Cleavage of Ig-Hepta at a “SEA” module and at a conserved G protein-coupled receptor proteolytic site. J Biol Chem. 2002 Jun 28;277(26):23391-8. PubMed PMID: 11973329.

Kwakkenbos MJ, Chang GW, Lin HH, Pouwels W, de Jong EC, van Lier RA, Gordon S, Hamann J. The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells. J Leukoc Biol. 2002 May;71(5):854-62. PubMed PMID: 11994511.

Mori K, Kanemura Y, Fujikawa H, Nakano A, Ikemoto H, Ozaki I, Matsumoto T, Tamura K, Yokota M, Arita N. Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells. Neurosci Res. 2002 May;43(1):69-74. PubMed PMID: 12074842.

Shima Y, Copeland NG, Gilbert DJ, Jenkins NA, Chisaka O, Takeichi M, Uemura T. Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development. Dev Dyn. 2002 Mar;223(3):321-32. PubMed PMID: 11891983.

Boltze C, Schneider-Stock R, Aust G, Mawrin C, Dralle H, Roessner A, Hoang-Vu C. CD97, CD95 and Fas-L clearly discriminate between chronic pancreatitis and pancreatic ductal adenocarcinoma in perioperative evaluation of cryocut sections. Pathol Int. 2002 Feb;52(2):83-8. PubMed PMID: 11940212.

Boulday G, Hamann J, Soulillou JP, Charreau B. CD97-decay-accelerating factor interaction is not involved in leukocyte adhesion to endothelial cells. Transplantation. 2002 Feb 15;73(3):429-36. PubMed PMID: 11884941.

Tobaben S, Südhof TC, Stahl B. Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha. J Biol Chem. 2002 Feb 22;277(8):6359-65. PubMed PMID: 11741895.

Duda DG, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F, Horii A, Tani K, Asano S, Nakamura Y, Matsuno S. Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. Br J Cancer. 2002 Feb 1;86(3):490-6. PubMed PMID: 11875720.

McMillan DR, Kayes-Wandover KM, Richardson JA, White PC. Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system. J Biol Chem. 2002 Jan 4;277(1):785-92. PubMed PMID: 11606593.

Südhof TC. alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins. Annu Rev Neurosci. 2001;24:933-62. Review. PubMed PMID: 11520923.

Formstone CJ, Little PF. The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development. Mech Dev. 2001 Nov;109(1):91-4. PubMed PMID: 11677057.

Caminschi I, Lucas KM, O’Keeffe MA, Hochrein H, Laâbi Y, Köntgen F, Lew AM, Shortman K, Wright MD. Molecular cloning of F4/80-like-receptor, a seven-span membrane protein expressed differentially by dendritic cell and monocyte-macrophage subpopulations. J Immunol. 2001 Oct 1;167(7):3570-6. PubMed PMID: 11564768.

Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B. Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 2001 Sep 15;61(18):6649-55. PubMed PMID: 11559528.

Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7934-9. PubMed PMID: 11438738.

Shimada Y, Usui T, Yanagawa S, Takeichi M, Uemura T. Asymmetric colocalization of Flamingo, a seven-pass transmembrane cadherin, and Dishevelled in planar cell polarization. Curr Biol. 2001 Jun 5;11(11):859-63. PubMed PMID: 11516647.

Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ. Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. J Biol Chem. 2001 Jun 1;276(22):18863-70. PubMed PMID: 11279179.

Lin HH, Stacey M, Saxby C, Knott V, Chaudhry Y, Evans D, Gordon S, McKnight AJ, Handford P, Lea S. Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex. J Biol Chem. 2001 Jun 29;276(26):24160-9. PubMed PMID: 11297558.

Jaspars LH, Vos W, Aust G, Van Lier RA, Hamann J. Tissue distribution of the human CD97 EGF-TM7 receptor. Tissue Antigens. 2001 Apr;57(4):325-31. PubMed PMID: 11380941.

Koh JT, Lee ZH, Ahn KY, Kim JK, Bae CS, Kim HH, Kee HJ, Kim KK. Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein. Brain Res Mol Brain Res. 2001 Mar 5;87(2):223-37. PubMed PMID: 11245925.

Nechiporuk T, Urness LD, Keating MT. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. J Biol Chem. 2001 Feb 9;276(6):4150-7. PubMed PMID: 11050079.


Volynski KE, Meunier FA, Lelianova VG, Dudina EE, Volkova TM, Rahman MA, Manser C, Grishin EV, Dolly JO, Ashley RH, Ushkaryov YA. Latrophilin, neurexin, and their signaling-deficient mutants facilitate alpha -latrotoxin insertion into membranes but are not involved in pore formation. J Biol Chem. 2000 Dec 29;275(52):41175-83. PubMed PMID: 11024019.

Van Renterghem C, Iborra C, Martin-Moutot N, Lelianova V, Ushkaryov Y, Seagar M. alpha-latrotoxin forms calcium-permeable membrane pores via interactions with latrophilin or neurexin. Eur J Neurosci. 2000 Nov;12(11):3953-62. PubMed PMID: 11069591.

Tobaben S, Südhof TC, Stahl B. The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family. J Biol Chem. 2000 Nov 17;275(46):36204-10. PubMed PMID: 10958799.

Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM. The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. J Biol Chem. 2000 Oct 20;275(42):32387-90. PubMed PMID: 10964907.

Gao FB, Kohwi M, Brenman JE, Jan LY, Jan YN. Control of dendritic field formation in Drosophila: the roles of flamingo and competition between homologous neurons. Neuron. 2000 Oct;28(1):91-101. PubMed PMID: 11086986.

Eichler W. CD97 isoform expression in leukocytes. J Leukoc Biol. 2000 Oct;68(4):561-7. PubMed PMID: 11037979.

Nikkila H, McMillan DR, Nunez BS, Pascoe L, Curnow KM, White PC. Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain. Mol Endocrinol. 2000 Sep;14(9):1351-64. PubMed PMID: 10976914.

Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ. Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. Genomics. 2000 Jul 15;67(2):188-200. PubMed PMID: 10903844.

Vincent JB, Skaug J, Scherer SW. The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1. DNA Res. 2000 Jun 30;7(3):233-5. PubMed PMID: 10907856.

Hayflick JS. A family of heptahelical receptors with adhesion-like domains: a marriage between two super families. J Recept Signal Transduct Res. 2000 May-Aug;20(2-3):119-31. Review. PubMed PMID: 10994649.

Ashton AC, Rahman MA, Volynski KE, Manser C, Orlova EV, Matsushita H, Davletov BA, van Heel M, Grishin EV, Ushkaryov YA. Tetramerisation of alpha-latrotoxin by divalent cations is responsible for toxin-induced non-vesicular release and contributes to the Ca(2+)-dependent vesicular exocytosis from synaptosomes. Biochimie. 2000 May;82(5):453-68. PubMed PMID: 10865132.

Kwakkenbos MJ, Chang GW, Lin HH, Pouwels W, de Jong EC, van Lier RA, Gordon S, Hamann J. The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells. J Leukoc Biol. 2002 May;71(5):854-62. PubMed PMID: 11994511.

Bittner, MA. Alpha-latrotoxin and its receptors CIRL (latrophilin) and neurexin 1 alpha mediate effects on secretion through multiple mechanisms. Biochimie. 2000 May;82(5):447-52. Review. PubMed PMID: 10865131.

Hamann J, van Zeventer C, Bijl A, Molenaar C, Tesselaar K, van Lier RA. Molecular cloning and characterization of mouse CD97. Int Immunol. 2000 Apr;12(4):439-48. PubMed PMID: 10744645.

Hlubek MD, Stuenkel EL, Krasnoperov VG, Petrenko AG, Holz RW. Calcium-independent receptor for alpha-latrotoxin and neurexin 1alpha facilitate toxin-induced channel formation: evidence that channel formation results from tethering of toxin to membrane. Mol Pharmacol. 2000 Mar;57(3):519-28. PubMed PMID: 10692492.

Hatanaka H, Oshika Y, Abe Y, Yoshida Y, Hashimoto T, Handa A, Kijima H, Yamazaki H, Inoue H, Ueyama Y, Nakamura M. Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1). Int J Mol Med. 2000 Feb;5(2):181-3. PubMed PMID: 10639598.

Oda K, Shiratsuchi T, Nishimori H, Inazawa J, Yoshikawa H, Taketani Y, Nakamura Y, Tokino T. Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. Cytogenet Cell Genet. 1999;84(1-2):75-82. PubMed PMID: 10343108.

Lu B, Usui T, Uemura T, Jan L, Jan YN. Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila. Curr Biol. 1999 Nov 4;9(21):1247-50. PubMed PMID: 10556092.

Qian YM, Haino M, Kelly K, Song WC. Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating factor (DAF, CD55). Immunology. 1999 Oct;98(2):303-11. PubMed PMID: 10540231.

Carver EA, Hamann J, Olsen AS, Stubbs L. Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication. Mamm Genome. 1999 Oct;10(10):1039-40. PubMed PMID: 10501980.

Warschkau H, Kiderlen AF. A monoclonal antibody directed against the murine macrophage surface molecule F4/80 modulates natural immune response to Listeria monocytogenes. J Immunol. 1999 Sep 15;163(6):3409-16. PubMed PMID: 10477612.

Usui T, Shima Y, Shimada Y, Hirano S, Burgess RW, Schwarz TL, Takeichi M, Uemura T. Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell. 1999 Sep 3;98(5):585-95. PubMed PMID: 10490098.

Abe J, Suzuki H, Notoya M, Yamamoto T, Hirose S. Ig-hepta, a novel member of the G protein-coupled hepta-helical receptor (GPCR) family that has immunoglobulin-like repeats in a long N-terminal extracellular domain and defines a new subfamily of GPCRs. J Biol Chem. 1999 Jul 9;274(28):19957-64. PubMed PMID: 10391944.

Hamann J, Wishaupt JO, van Lier RA, Smeets TJ, Breedveld FC, Tak PP. Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue. Arthritis Rheum. 1999 Apr;42(4):650-8. PubMed PMID: 10211878.

Hoang-Vu C, Bull K, Schwarz I, Krause G, Schmutzler C, Aust G, Köhrle J, Dralle H. Regulation of CD97 protein in thyroid carcinoma. J Clin Endocrinol Metab. 1999 Mar;84(3):1104-9. PubMed PMID: 10084602.

Zendman AJ, Cornelissen IM, Weidle UH, Ruiter DJ, van Muijen GN. TM7XN1, a novel human EGF-TM7-like cDNA, detected with mRNA differential display using human melanoma cell lines with different metastatic potential. FEBS Lett. 1999 Mar 12;446(2-3):292-8. PubMed PMID: 10100861.

Ichtchenko K, Bittner MA, Krasnoperov V, Little AR, Chepurny O, Holz RW, Petrenko AG. A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors. J Biol Chem. 1999 Feb 26;274(9):5491-8. PubMed PMID: 10026162.

Krasnoperov V, Bittner MA, Holz RW, Chepurny O, Petrenko AG. Structural requirements for alpha-latrotoxin binding and alpha-latrotoxin-stimulated secretion. A study with calcium-independent receptor of alpha-latrotoxin (CIRL) deletion mutants. J Biol Chem. 1999 Feb 5;274(6):3590-6. PubMed PMID: 9920906.

Liu M, Parker RM, Darby K, Eyre HJ, Copeland NG, Crawford J, Gilbert DJ, Sutherland GR, Jenkins NA, Herzog H. GPR56, a novel secretin-like human G-protein-coupled receptor gene. Genomics. 1999 Feb 1;55(3):296-305. PubMed PMID: 10049584.

Rahman MA, Ashton AC, Meunier FA, Davletov BA, Dolly JO, Ushkaryov YA. Norepinephrine exocytosis stimulated by alpha-latrotoxin requires both external and stored Ca2+ and is mediated by latrophilin, G proteins and phospholipase C. Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1381):379-86. Review. PubMed PMID: 10212487.

Matsushita H, Lelianova VG, Ushkaryov YA. The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution. FEBS Lett. 1999 Jan 29;443(3):348-52. PubMed PMID: 10025961.


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Hadjantonakis AK, Formstone CJ, Little PF. mCelsr1 is an evolutionarily conserved seven-pass transmembrane receptor and is expressed during mouse embryonic development. Mech Dev. 1998 Nov;78(1-2):91-5. PubMed PMID: 9858697

Fukushima Y, Oshika Y, Tsuchida T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Ueyama Y, Tamaoki N, Nakamura M. Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer. Int J Oncol. 1998 Nov;13(5):967-70. PubMed PMID: 9772287.

Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y. Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1. Biochem Biophys Res Commun. 1998 Oct 9;251(1):158-65. PubMed PMID: 9790924.

Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O. Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. Genomics. 1998 Jul 1;51(1):27-34. PubMed PMID: 9693030.

Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T. Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. Biochem Biophys Res Commun. 1998 Jun 29;247(3):597-604. PubMed PMID: 9647739.

Hamann J, Stortelers C, Kiss-Toth E, Vogel B, Eichler W, van Lier RA. Characterization of the CD55 (DAF)-binding site on the seven-span transmembrane receptor CD97. Eur J Immunol. 1998 May;28(5):1701-7. PubMed PMID: 9603477.

Bittner MA, Krasnoperov VG, Stuenkel EL, Petrenko AG, Holz RW. A Ca2+-independent receptor for alpha-latrotoxin, CIRL, medites effects on secretion via multiple mechanisms. J Neurosci. 1998 Apr 15;18(8):2914-22. PubMed PMID: 9526008.

McKnight AJ, Gordon S. The EGF-TM7 family: unusual structures at the leukocyte surface. J Leukoc Biol. 1998 Mar;63(3):271-80. Review. PubMed PMID: 9500513.

Lang J, Ushkaryov Y, Grasso A, Wollheim CB. Ca2+-independent insulin exocytosis induced by alpha-latrotoxin requires latrophilin, a G protein-coupled receptor. EMBO J. 1998 Feb 2;17(3):648-57. PubMed PMID: 9450990.


Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). Cytogenet Cell Genet. 1997;79(1-2):103-8. PubMed PMID: 9533023.

McKnight AJ, Macfarlane AJ, Seldin MF, Gordon S. Chromosome mapping of the Emr1 gene. Mamm Genome. 1997 Dec;8(12):946. PubMed PMID: 9383301.

Eichler W, Hamann J, Aust G. Expression characteristics of the human CD97 antigen. Tissue Antigens. 1997 Nov;50(5):429-38. PubMed PMID: 9389316.

Nishimori H, Shiratsuchi T, Urano T, Kimura Y, Kiyono K, Tatsumi K, Yoshida S, Ono M, Kuwano M, Nakamura Y, Tokino T. A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis. Oncogene. 1997 Oct;15(18):2145-50. PubMed PMID: 9393972.

Lelianova VG, Davletov BA, Sterling A, Rahman MA, Grishin EV, Totty NF, Ushkaryov YA. Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. J Biol Chem. 1997 Aug 22;272(34):21504-8. PubMed PMID: 9261169.

Iwai Y, Usui T, Hirano S, Steward R, Takeichi M, Uemura T. Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the Drosophila embryonic CNS. Neuron. 1997 Jul;19(1):77-89. PubMed PMID: 9247265.

Krasnoperov VG, Bittner MA, Beavis R, Kuang Y, Salnikow KV, Chepurny OG, Little AR, Plotnikov AN, Wu D, Holz RW, Petrenko AG. alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Neuron. 1997 Jun;18(6):925-37. PubMed PMID: 9208860.

Aust G, Eichler W, Laue S, Lehmann I, Heldin NE, Lotz O, Scherbaum WA, Dralle H, Hoang-Vu C. CD97: a dedifferentiation marker in human thyroid carcinomas. Cancer Res. 1997 May 1;57(9):1798-806. PubMed PMID: 9135025.

Lin HH, Stubbs LJ, Mucenski ML. Identification and characterization of a seven transmembrane hormone receptor using differential display. Genomics. 1997 May 1;41(3):301-8. PubMed PMID: 9169125.

Osterhoff C, Ivell R, Kirchhoff C. Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily. DNA Cell Biol. 1997 Apr;16(4):379-89. PubMed PMID: 9150425.


van Lier RA, Eichler W, Hamann J. Sevenspan transmembrane molecules: novel receptors involved in leukocyte adhesion. Immunol Lett. 1996 Dec;54(2-3):185-7. Review. PubMed PMID: 9052875.

Gray JX, Haino M, Roth MJ, Maguire JE, Jensen PN, Yarme A, Stetler-Stevenson MA, Siebenlist U, Kelly K. CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. J Immunol. 1996 Dec 15;157(12):5438-47. PubMed PMID: 8955192.

Krasnoperov VG, Beavis R, Chepurny OG, Little AR, Plotnikov AN, Petrenko AG. The calcium- independent receptor of alpha-latrotoxin is not a neurexin. Biochem Biophys Res Commun. 1996 Oct 23;227(3):868-75. PubMed PMID: 8886023.

Davletov BA, Shamotienko OG, Lelianova VG, Grishin EV, Ushkaryov YA. Isolation and biochemical characterization of a Ca2+-independent alpha-latrotoxin-binding protein. J Biol Chem. 1996 Sep 20;271(38):23239-45. PubMed PMID: 8798521.

Hamann J, Vogel B, van Schijndel GM, van Lier RA. The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF). J Exp Med. 1996 Sep 1;184(3):1185-9. PubMed PMID: 9064337.

McKnight AJ, Gordon S. EGF-TM7: a novel subfamily of seven-transmembrane-region leukocyte cell-surface molecules. Immunol Today. 1996 Jun;17(6):283-7. Review. PubMed PMID: 8962632.

Haidl ID, Jefferies WA. The macrophage cell surface glycoprotein F4/80 is a highly glycosylated proteoglycan. Eur J Immunol. 1996 May;26(5):1139-46. PubMed PMID: 8647179.

Hamann J, Hartmann E, van Lier RA. Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily. Genomics. 1996 Feb 15;32(1):144-7. PubMed PMID: 8786105.

McKnight AJ, Macfarlane AJ, Dri P, Turley L, Willis AC, Gordon S. Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family. J Biol Chem. 1996 Jan 5;271(1):486-9. PubMed PMID: 8550607.


Hamann J, Eichler W, Hamann D, Kerstens HM, Poddighe PJ, Hoovers JM, Hartmann E, Strauss M, van Lier RA. Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain. J Immunol. 1995 Aug 15;155(4):1942-50. PubMed PMID: 7636245.

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Hume DA, Perry VH, Gordon S. The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophagesassociated with epithelia. Anat Rec. 1984 Nov;210(3):503-12. PubMed PMID: 6524692.

Hume DA, Halpin D, Charlton H, Gordon S. The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of endocrine organs. Proc Natl Acad Sci U S A. 1984 Jul;81(13):4174-7. PubMed PMID: 6377311.

Hume DA, Loutit JF, Gordon S. The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of bone and associated connective tissue. J Cell Sci. 1984 Mar;66:189-94. PubMed PMID: 6378941.


Hume DA, Robinson AP, MacPherson GG, Gordon S. The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, anddendritic cells in lymphoid and hematopoietic organs. J Exp Med. 1983 Nov 1;158(5):1522-36. PubMed PMID: 6355361.

Hume DA, Gordon S. Mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex. J Exp Med. 1983 May 1;157(5):1704-9. PubMed PMID: 6854206.


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