The AGC recommends the usage of the terminology provided on this page in any publications.
(A) Topology- and cleavage-based compartmentation of Adhesion GPCR architecture. The protein layout of all Adhesion GPCRs is marked by a three-partite structure consisting of ECD, 7TM domain, and ICD. Alternatively, Adhesion GPCRs that undergo autoproteolysis also display a two-partite structure containing the NTF and the CTF. (B) The GAIN domain is a complex fold that mediates autoproteolysis and subsequent attachment of the cleaved NTF and CTF fragments. The domain is divided into two subdomains (A and B), of which the latter one is cleaved at the GPS located inside the GPS motif. Hence, the GAIN domain parts N-terminal to the GPS belong to the NTF, whereas the C-terminal portion is accommodated within the CTF. (From Langenhan et al., Sci Signal. 2013 May 21;6(276):re3)
Together with the IUPHAR nomenclature committee (NC-IUPHAR), the AGC has developed a new nomenclature for Adhesion GPCRs:
Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev. 2015 Apr;67(2):338-67. PubMed PMID: 25713288.
The AGC strongly encourages the usage of this new nomenclature in all publications. For discussing the new nomenclature, please contact Helgi Schiöth